Local delivery of antimicrobial agents for the treatment of periodontal diseases

Schwach-Abdellaoui, Khadija; Vivien-Castioni, N; Gurny, Robert

doi:10.1016/s0939-6411(00)00086-2

Cited by 189 publications

(146 citation statements)

References 77 publications

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“…The MBC endpoint is defined as the lowest concentration of antimicrobial agent that kills .99.9% of the initial bacterial population where no visible growth of the bacteria was observed on the plates. 16 Figure 2 h-Nuclear magnetic resonance spectrum of synthesized PEGylated PLGA in CDCL 3 . Abbreviations: PEG, poly(ethylene) glycol; PLGA, poly(lactic-co-glycolic acid).…”

Section: Antibacterial Properties Of Minocycline-loaded Nanoparticlesmentioning

confidence: 99%

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Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Dinarvand¹,

Kashi²,

Eskandarion³

et al. 2012

IJN

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Background: Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective of this work was to investigate different methods of producing PLGA nanoparticles containing minocycline, a drug suitable for periodontal infections. Methods: Different methods, such as single and double solvent evaporation emulsion, ion pairing, and nanoprecipitation were used to prepare both PLGA and PEGylated PLGA nanoparticles. The resulting nanoparticles were analyzed for their morphology, particle size and size distribution, drug loading and entrapment efficiency, thermal properties, and antibacterial activity. Results: The nanoparticles prepared in this study were spherical, with an average particle size of 85-424 nm. The entrapment efficiency of the nanoparticles prepared using different methods was as follows: solid/oil/water ion pairing (29.9%) . oil/oil (5.5%) . water/oil/water (4.7%) . modified oil/water (4.1%) . nano precipitation (0.8%). Addition of dextran sulfate as an ion pairing agent, acting as an ionic spacer between PEGylated PLGA and minocycline, decreased the water solubility of minocycline, hence increasing the drug entrapment efficiency. Entrapment efficiency was also increased when low molecular weight PLGA and high molecular weight dextran sulfate was used. Drug release studies performed in phosphate buffer at pH 7.4 indicated slow release of minocycline from 3 days to several weeks. On antibacterial analysis, the minimum inhibitory concentration and minimum bactericidal concentration of nanoparticles was at least two times lower than that of the free drug. Conclusion: Novel minocycline-PEGylated PLGA nanoparticles prepared by the ion pairing method had the best drug loading and entrapment efficiency compared with other prepared nanoparticles. They also showed higher in vitro antibacterial activity than the free drug.

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Section: Antibacterial Properties Of Minocycline-loaded Nanoparticlesmentioning

confidence: 99%

“…Several specialized local delivery systems have been designed for controlled release of antibiotics in periodontal tissues. 15,16 The complexity of access to periodontal tissues makes all of these systems only partially successful. 17 There are a few studies about preparation of antibacterial nanoparticles for periodontal therapy.…”

Section: Introductionmentioning

confidence: 99%

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Dinarvand¹,

Kashi²,

Eskandarion³

et al. 2012

IJN

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“…Other advantages include achieving high intrasulcular drug concentrations and better patient compliance. [19,20] Therefore, this study has evaluated the effi cacy of subgingival delivery of simvastatin as an adjunct to scaling and root planing.…”

Section: Discussionmentioning

confidence: 99%

Effect of subgingivally delivered simvastatin in postmenopausal women with chronic periodontitis: A randomized controlled trial

Gaekwad¹,

Gujjari²,

Kumar³

et al. 2015

JCRI

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Background and Objectives:The defi ciency of estrogen at menopause is a contributing factor that increases susceptibility to resorption due to periodontal infl ammation. Statins have been used successfully in postmenopausal osteopenia. Simvastatin has antiinfl ammatory and antiresorptive properties. This study assessed subgingivally delivered 1.2 mg simvastatin in situ gel in postmenopausal women with chronic periodontitis. Materials and Methods: A total of 40 bilateral pockets (≥4 mm) in 20 systemically healthy postmenopausal subjects were randomized as site A and B, which received either the simvastatin in situ gel or placebo gel after scaling and root planing. Site-specifi c indices, probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, 3 and 6 months. The data were analyzed using descriptive statistics, repeated measure ANOVA, paired and independent samples t-test. Results: A statistically signifi cant (P < 0.05) decrease in PD and improved CAL was observed in both groups over 3 and 6 months. The comparisons of clinical parameters showed statistically signifi cant (P < 0.05) improvements in test sites over the control sites. Conclusion: Simvastatin in situ gel showed improvements in clinical parameters and prolonged anti-infl ammatory eff ects. The results encourage the use of simvastatin in situ gel for the predictable treatment of chronic periodontitis in postmenopausal women.

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“…6 Periodontal pockets form the primary source of infections with regard to periodontal infections; local drug delivery in the form of intrapocket administration of drugs will prove to be more advantageous than systemic administration. 3,7 Due to tissue invasive nature of some periodontal pathogens using mechanical therapy alone is ineffective. Therefore local administration of drugs can deliver higher concentra tions directly into diseased sites reducing the microbial load.…”

Section: Introductionmentioning

confidence: 99%

Perioceutics in the management of Periodontal Disease

Arunachalam¹,

Rajeev²,

Vedam³

et al. 2017

JYP

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Local delivery of antimicrobial agents for the treatment of periodontal diseases

Cited by 189 publications

References 77 publications

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Improved drug loading and antibacterial activity of minocycline-loaded PLGA nanoparticles prepared by solid/oil/water ion pairing method

Effect of subgingivally delivered simvastatin in postmenopausal women with chronic periodontitis: A randomized controlled trial

Perioceutics in the management of Periodontal Disease

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