Local deformation in a hydrogel induced by an external magnetic field

Vikingsson, L.; Vinals-Guitart, Alvaro; Valera-Martínez, Alfonso; Riera, Jaime; Vidaurre, Ana; Ferrer, Gloria Gallego; Ribelles, J.L. Gómez

doi:10.1007/s10853-016-0226-8

Cited by 6 publications

(9 citation statements)

References 40 publications

(31 reference statements)

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“…In both cases, the microspheres are porous (Figure 3b and 3e) probably due to the solvent evaporation process during the o/w emulsion. The same morphology change pattern was described by Vikingsson et al [19] when producing magnetic PLLA (poly-L-lactic acid) microspheres via the same o/w emulsion method. Size distribution ranged between 17 and 287 μm (Figure 3f) with an average size of 143± 38 μm for the magnetic 5% AA microspheres.…”

Section: Microsphere Production Functionalization and Characterizationssupporting

confidence: 54%

“…Microspheres were produced via an oil/water (o/w) emulsion method with solvent evaporation. [19] The aqueous phase consisted of a solution of polyvinylalcohol (PVA, Sigma-Aldrich) in MiliQ water (4% w/v) and the organic phase was the polymer dissolved in chloroform (Scharlau) (3% w/v). Ferrite nanoparticles (MNPs, EMG1300 Ferrotec Ferrofluids, nominal particle diameter: 10 nm) were added to the organic phase to confer magnetic properties on the resulting microspheres, MNPs were added at 5% w/w with respect to the polymer weight.…”

Section: Microsphere Productionmentioning

confidence: 99%

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Biomimetic microspheres for 3D mesenchymal stem cell culture and characterization

Clara-Trujillo

Marín-Payá

Cordón

et al. 2019

Colloids and Surfaces B: Biointerfaces

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Stem cells reside in niches, specialized microenvironments that sustain and regulate their fate. Extracellular matrix (ECM), paracrine factors or other cells are key niche regulating elements. As the conventional 2D cell culture lacks these elements, it can alter the properties of naïve stem cells. In this work we designed a novel biomimetic microenvironment for cell culture, consisting of magnetic microspheres, prepared with acrylates and acrylic acid copolymers and functionalized with fibronectin or hyaluronic acid as ECM coatings. To characterize cell proliferation and adhesion, porcine mesenchymal stem cells (MSCs) were grown with the different microspheres. The results showed that the 3D environments presented similar proliferation to the 2D culture and that fibronectin allows cell adhesion, while hyaluronic acid hinders it. In the 3D environments, cells reorganize the microspheres to grow in aggregates, highlighting the advantages of microspheres as 3D environments and allowing the cells to adapt the environment to their requirements.

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Section: Microsphere Production Functionalization and Characterizationssupporting

confidence: 54%

Section: Microsphere Productionmentioning

confidence: 99%

Biomimetic microspheres for 3D mesenchymal stem cell culture and characterization

Clara-Trujillo

Marín-Payá

Cordón

et al. 2019

Colloids and Surfaces B: Biointerfaces

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“…Up to now, many attempts have been made to fabricate soft actuators sensitive to external stimuli. [76] Especially, MHs with flexibility and sensitivity to external magnetic fields are expected to form a new research focus in the coming era of soft robots. [77] What is more, taking advantage of the minimal invasions and the drive ability to use magnetic fields of magnetic microrobots, therapeutic drugs can be delivered to target areas.…”

Section: Intelligent Responsementioning

confidence: 99%

Multi‐functional magnetic hydrogel: Design strategies and applications

et al. 2021

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Hydrogel is one of the hottest biomaterials in recent years. Especially, magnetic hydrogels (MHs) prepared by combining unique magnetic nanoparticles (MNPs) with hydrogels have attracted wide attention due to their excellent biocompatibility, mechanical properties, absorbability and rich magnetic properties (magnetocaloric, magnetic resonance imaging and intelligent response, etc.).However, the current literature mainly focuses on the application of MHs, without fully understanding the relationship between the design strategies and applications of each function in MHs. This review highlights six major functional properties of MHs, including mechanical properties, adsorption, magnetocaloric effect, magnetic resonance (MR) imaging, intelligent response and biocompatibility. Principles and design strategies of each performance are thoroughly analyzed. Furthermore, the latest applications of MHs in biomedicine, soft actuators, environmental protection, chemistry and engineering in recent 5 years are introduced from the perspective of each function. In the carefully selected representative cases, the design strategies and application principle of multi-functional MHs are detailed, respectively. The classical fabrication processing of MHs is summarized. At last, we discuss the unmet needs and potential future challenges in MHs development and highlight its emerging strategies.

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“…18,19 MNPs embedded in thermosensitive hydrogel has been applied to modulate drug release driven by matrix response to temperature changing induced by heat effect of high frequency alternating magnetic field. 20,21 However, the drug release behavior was achieved by converting high frequency alternating magnetic field into heat to induce volume change or phase change of ferrogel. The temperature increase may disturb the drug release mechanism and involve the issue of potential risk for biological tissue.…”

Section: ■ Introductionmentioning

confidence: 99%

Tough Magnetic Chitosan Hydrogel Nanocomposites for Remotely Stimulated Drug Release

Wang

et al. 2018

Biomacromolecules

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As one of important biomaterials for localized drug delivery system, chitosan hydrogel still suffer several challenges, including poor mechanical properties, passive drug release behavior and lack of remote stimuli response. To address these challenges, a facile in situ hybridization method was reported for fabricate tough magnetic chitosan hydrogel (MCH), which remotely switched drug release from passive release to pulsatile release under a low frequency alternating magnetic field (LAMF). The in situ hybridization method avoided the aggregation of magnetic nanoparticles (MNPs) in hydrogel, which simultaneously brings 416% and 265% increase in strength and elastic modulus, respectively. The mechanical property enhancement was contributed by the physical crosslinking of in situ synthesized MNPs. When a LAMF with 15 min ON-15 min OFF cycles was applied to MCH, the fraction release showed zigzag shape and pulsatile release behavior with quick response. The cumulative release and fraction release of drug from MCH were improved by 67.2% and 31.9%, respectively. MTT results and cell morphology indicated that the MCH have excellent biocompatibility and no acute adverse effect on MG-63 cells. The developed tough MCH system holds great potential for applications in smart drug release system with noninvasive characteristics and magnetic field stimulated drug release behavior.

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Local deformation in a hydrogel induced by an external magnetic field

Abstract: The aim of this study is to prove the feasibility of a system able to apply local mechanical loading on cells for tissue engineering applications. This experimental study is based on a previously developed artificial cartilage model with different

Cited by 6 publications

References 40 publications

Biomimetic microspheres for 3D mesenchymal stem cell culture and characterization

Biomimetic microspheres for 3D mesenchymal stem cell culture and characterization

Multi‐functional magnetic hydrogel: Design strategies and applications

Tough Magnetic Chitosan Hydrogel Nanocomposites for Remotely Stimulated Drug Release

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