Local cytokines and clinical symptoms in children with allergic rhinitis after different treatments

Segundo, Gesmar Rs; Gomes, Fabíola Alves; Fernandes, Karla P.; Alves, Ronaldo; Silva, Deise Ao; Taketomi, Ernesto Akio

doi:10.2147/btt.2009.3595

Cited by 3 publications

(1 citation statement)

References 30 publications

(19 reference statements)

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“…The finding of rye grass pollen-specific IgG, IgA, and IgE in the nasal secretions and sera of patients with AR suggests that the nasal mucosa may be the source of allergen-specific IgE in peripheral blood [ 10 ]. Although a few studies have measured nasal cytokines in children with AR [ 11 , 12 ], little is known about local immunity in children with AR. Moreover, there is no information available on local immunity changing from children to adults with AR.…”

Section: Introductionmentioning

confidence: 99%

Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis

Lee

Shim

et al. 2016

PLoS ONE

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BackgroundAllergic rhinitis (AR) is the most common allergic disease but little is known about the difference of local immune responses in children and adults with AR.ObjectiveTo compare local immune responses between children and adults with AR and nonallergic rhinitis (NAR), and to investigate whether the association of local and systemic immune responses is different between the two age groups.MethodsFifty-one patients with chronic rhinitis were enrolled and grouped into children (N = 27, mean age 7.2 years) and adults (N = 24, mean age 29.9 years). Diagnosis of AR was based on symptoms, skin prick tests and serum specific IgEs. Nasal lavage (NAL) fluids were collected from all subjects and used to measure the levels of total IgE, specific IgEs to house dust mites (Dp and Df), and cytokines (TNF-α, IL-4, IL-10, IL-17A and IFN-γ). Flow cytometry was used to measure inflammatory cell types in NAL fluids.ResultsAR had significantly increased local levels of total IgE and specific IgEs to Dp and Df compared with NAR in both age groups (P < 0.05). Nasal eosinophils % (P = 0.01) was significantly increased only in children with AR. Local-systemic correlations of total IgE (r = 0.662, P = 0.000) and eosinophil % (r = 0.461, P = 0.015) between the peripheral blood and NAL fluids were found only in children. Moreover, children had correlations between total IgE and eosinophil % in the peripheral blood (r = 0.629, P = 0.001) and in NAL fluids (r = 0.373, P = 0.061).ConclusionElevated local IgE is a common feature of AR in children and adults. Local measures in NAR showed naïve state of immune response which disagree with the hypothesis of local allergic rhinitis. Children showed intense local inflammation and close local-systemic interactions compared to adults supporting pediatric AR as a distinct feature.

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Section: Introductionmentioning

confidence: 99%

Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis

Lee

Shim

et al. 2016

PLoS ONE

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Mediators and Cytokines in Persistent Allergic Rhinitis and Nonallergic Rhinitis with Eosinophilia Syndrome

Gröger

Klemens

Wendt

et al. 2012

Int Arch Allergy Immunol

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Background: Patients with nonallergic rhinitis with eosinophilia syndrome (NARES) show typical symptoms of persistent allergic rhinitis (PAR). The aim of the present study was to compare nasal cytokine patterns between NARES and PAR. Methods: Nasal secretions of 31 patients suffering from NARES, 20 patients with PAR to house dust mite and 21 healthy controls were collected using the cotton wool method and analyzed for interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) by Bio-Plex Cytokine Assay as well as eosinophil cationic protein (ECP) and tryptase by UniCAP-FEIA. Results: NARES and PAR presented elevated levels of tryptase, while ECP was markedly increased solely in NARES compared to both the controls and PAR. Elevated levels of IL-1β, IL-17, IFN-γ, TNF-α and MCP-1 were found in NARES compared to the controls as well as PAR. MIP-1β was elevated in NARES and PAR, while IL-4, IL-6 and G-CSF showed increased levels in NARES, and IL- 5 was elevated in PAR only. Conclusions: In patients with NARES and PAR, eosinophils and mast cells appear to be the pivotal cells of inflammation, reflected by high levels of tryptase and ECP as well as IL-5 and GM-CSF as factors for eosinophil migration and survival. The elevated levels of proinflammatory cytokines in NARES may indicate the chronic, self-perpetuating process of inflammation in NARES which seems to be more pronounced than in PAR. IL-17 might be a factor for neutrophilic infiltration or be responsible for remodeling processes in NARES.

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Mometasone Furoate Nasal Spray Effects on Seasonal Grass Pollinosis

2010

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Local cytokines and clinical symptoms in children with allergic rhinitis after different treatments

Cited by 3 publications

References 30 publications

Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis

Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis

Mediators and Cytokines in Persistent Allergic Rhinitis and Nonallergic Rhinitis with Eosinophilia Syndrome

Mometasone Furoate Nasal Spray Effects on Seasonal Grass Pollinosis

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