Local Corticosterone Infusion Enhances Nocturnal Pineal Melatonin Production <i>In Vivo</i>

Fernandes, Pedro Augusto Carlos Magno; Bothorel, Béatrice; Clesse, Daniel; Monteiro, Alex Willian Arantes; Calgari, Christiane; Raison, Sylvie; Simonneaux, V.; Markus, Regina Pekelmann

doi:10.1111/j.1365-2826.2008.01817.x

Cited by 48 publications

(68 citation statements)

References 41 publications

(61 reference statements)

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“…Corticosterone was shown to increase melatonin synthesis in vitro after low noradrenergic stimulation [9,21] and in vivo after mild stress [27], local transpineal perfusion of corticosterone [26] and during chronic inflammation [29]. Our present data show that corticosterone potentiates pineal hormonal production only when the glands are incubated with a β-adrenergic agonist, reinforcing that the pattern of adrenoceptor stimulation is the driving force for the final effect induced by corticosterone on pineal function.…”

Section: Discussionsupporting

confidence: 52%

“…However, previous literature data show controversial results regarding this crosstalk, indicating both stimulatory and inhibitory effects of glucocorticoids on pineal melatonin synthesis [9,21,22,23,24,25,26,27,28,29]. The present study shows that the pattern of adrenergic activation in the pineal gland regulates the direction of the corticosterone effect on melatonin synthesis (fig.…”

Section: Discussionmentioning

confidence: 66%

“…Similarly, in vivo data show that perfusion of a high corticosterone concentration [23], or stress-induced plasma corticosterone elevation [24,25], inhibits pineal melatonin synthesis. This contrasts to transpineal infusion of a high corticosterone concentration [26], mild restraint stress in rats [27] or thermic stress in goats [28], which potentiate pineal melatonin production. Likewise, adrenalectomy (ADX) reverses the reduction in the nocturnal melatonin surge induced by intense acute stress [25] but decreases melatonin levels in chronic inflamed mice [29].…”

Section: Introductionmentioning

confidence: 99%

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Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis

et al. 2016

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Background/Aim: The nocturnal production of melatonin by the pineal gland is triggered by sympathetic activation of adrenoceptors and may be modulated by immunological signals. The effect of glucocorticoids on nocturnal melatonin synthesis is controversial; both stimulatory and inhibitory effects have been reported. During pathophysiological processes, an increased sympathetic tonus could result in different patterns of adrenoceptor activation in the pineal gland. Therefore, in this investigation, we evaluated whether the pattern of adrenergic stimulation of the pineal gland drives the direction of the glucocorticoid effect on melatonin production. Methods: The corticosterone effect on the pineal hormonal production induced by β-adrenoceptor or β+α₁-adrenoceptor activation was evaluated in cultured glands. We also investigated whether the in vivo lipopolysaccharide (LPS)-induced inhibition of melatonin is dependent on the interaction of glucocorticoids and the α₁-adrenoceptor in adrenalectomized animals and on the in vivo blockade of glucocorticoid receptors (GRs) or the α₁-adrenoceptor. Results: Corticosterone potentiated β-adrenoceptor-induced pineal melatonin synthesis, whilst corticosterone-dependent inhibition was observed when melatonin production was induced by β+α₁-adrenoceptors agonists. The inhibitory effect of corticosterone is mediated by GR, as it was abolished in the presence of a GR antagonist. Moreover, LPS-induced reduction in melatonin nocturnal plasma content was reversed by adrenalectomy and by antagonizing GR or α₁-adrenoceptors. Conclusions: The dual effect of corticosterone on pineal melatonin synthesis is determined by the activation pattern of adrenoceptors (β or β+α₁) in the gland during GR activation, suggesting that increased activation of the sympathetic system and the hypothalamic-pituitary-adrenal axis are necessary for the control of melatonin production during defense responses.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

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Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis

et al. 2016

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“…Another interesting point is that the melatonin level was significantly higher on the 2nd postoperative day when the patients with higher cortisol levels were compared to those with lower cortisol levels. This result is in accordance with data obtained in rats, where transpineal corticosterone perfusion increases the nocturnal melatonin surge [9]. In addition, noradrenaline-induced melatonin biosynthesis in cultured pineal glands is also potentiated by glucocorticoids [8].…”

Section: Discussionsupporting

confidence: 81%

“…The restoration of the nocturnal melatonin peak depends on the reduction in the initial stimuli and the effect of anti-inflammatory mediators, which follow the proinflammatory phase. Indeed, we have shown that in rodents the increase in circulating adrenal glucocorticoids during chronic inflammation or the direct injection of corticosterone by microdialysis increases the nocturnal melatonin output [6,7,8,9]. During the progression of the innate immune response, mononuclear cells, mainly macrophages, are induced to synthesize melatonin, which plays a role as an anti-inflammatory mediator [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

The Concept of the Immune-Pineal Axis Tested in Patients Undergoing an Abdominal Hysterectomy

Tatsch-Dias¹,

Levandovski

Souza³

et al. 2013

Neuroimmunomodulation

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Objective: Activation of the immune-pineal axis induces a transient reduction in nocturnal melatonin in the plasma during the proinflammatory phase of an innate immune response to allow the proper migration of leukocytes to the lesion site. This transient reduction should be regulated by inflammatory mediators, which are responsible for the fine-tuning of the process. In the present study, we measured the pre- and postoperative serum concentrations of melatonin, tumor necrosis factor (TNF) and cortisol in women who underwent an elective hysterectomy and correlated the variation in melatonin with postoperative pain. Methods: We evaluated 12 women who had an abdominal hysterectomy. Blood was collected at 10.00 and 22.00 h 1 week and 1 day before the surgery, on the 1st and 2nd days after the surgery and at 22.00 h on the day of the surgery. Results: On the night after the surgery, there was no melatonin detected at 22.00 h. High TNF levels were accompanied by a lower nocturnal melatonin output, higher postoperative pain according to a visual analog scale and the request of higher doses of analgesics. In addition, low cortisol levels were accompanied by a lower nocturnal melatonin output. Conclusion: Our results confirm that the same antagonistic pattern between TNF and glucocorticoids observed in cultured pineal glands also occurs in humans. This integrative pattern suggests that the cross talk between the immune and endocrine system orchestrates longitudinal changes in pineal activity, reinforcing the hypothesis of an immune-pineal axis.

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Contaminated meal intake (Aeromonas hydrophila) does not elicit hormonal or immune modulation in bullfrogs (Lithobates catesbeianus)

et al. 2023

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The gastrointestinal tract (GIT) is colonized by resident microbiota but contact with foreign microbiota during feeding can impair GIT functions. During meal digestion, several vertebrates modulate the systemic immune function and immunoregulatory hormones concentration. However, in ectothermic animals, it is not known if this hormonal and immune modulation during the postprandial period is affected by the presence of pathogenic microbiota in the food. This study aimed to investigate the effects of contaminated meal ingestion on hormonal and innate immune responses in bullfrogs (Lithobates catesbeianus). Bullfrogs were divided into three treatments: fed three times with sterilized fish feed (control group), fed twice with sterilized fish feed and once with fish feed containing live bacteria (Aeromonas hydrophila, 109 UFC/mL), and fed three times with fish feed containing live bacteria. Blood and GIT tissues were collected 24 h after treatments to measure plasma and tissue corticosterone levels, NL ratio, and plasma bacterial killing ability. The ingestion of contaminated meal did not affect the hormonal and immune parameters. In conclusion, ingestion of contaminated food was not capable of intensifying the hypothalamic–pituitary–interrenal axis activation and the consequent hormonal and immune responses observed after feeding in bullfrogs. However, our results suggest that the ingestion of three contaminated meals tended to decrease stomach corticosterone levels (nonstatistically significant), possibly contributing to preventing the transmigration of the bacteria to organs outside the GIT.

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Local Corticosterone Infusion Enhances Nocturnal Pineal Melatonin Production In Vivo

Cited by 48 publications

References 41 publications

Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis

Dual Effect of Catecholamines and Corticosterone Crosstalk on Pineal Gland Melatonin Synthesis

The Concept of the Immune-Pineal Axis Tested in Patients Undergoing an Abdominal Hysterectomy

Contaminated meal intake (Aeromonas hydrophila) does not elicit hormonal or immune modulation in bullfrogs (Lithobates catesbeianus)

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