Local control of hepatic arterial and portal venous flow in the dog

Hanson, KM; Pc, Johnson

doi:10.1152/ajplegacy.1966.211.3.712

Cited by 155 publications

(91 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is of interest to note that the increase in liver blood flow was not primarily due to an increase in hepatic artery flow, but rather to an increase in flow to the gastrointestinal tract, in particular the small intestine, without any change in weight of these organs. This is consistent with the hypothesis that total liver blood flow is regulated by a myogenic mechanism, influencing the splanchnic arterial supply more than the hepatic artery, and that the control of the total flow is closely related to liver mass (13).…”

Section: Discussionsupporting

confidence: 91%

Increased Clearance of Antipyrine and d-Propranolol after Phenobarbital Treatment in the Monkey

Branch¹,

Shand²,

Wilkinson³

et al. 1974

J. Clin. Invest.

132

View full text Add to dashboard Cite

A B S T R A C T The effects of phenobarbital treatment for 12 days on the regional distribution of blood flow and on the disposition of two model drugs, antipyrine and d-propranolol, have been determined in six unanesthetized rhesus monkeys. Phenobarbital significantly increased total hepatic blood flow from 179±15 to 239± 27 ml/min. Liver weight was increased to a similar degree (34%) in phenobarbital-treated animals as compared to control monkeys. The clearance of both antipyrine and d-propranolol was increased and the halflife decreased significantly by phenobarbital. Analysis of the data by a perfusion-limited pharmacokinetic model showed that the changes in antipyrine clearance were due almost entirely to enzyme induction. On the other hand, with d-propranolol, the increase in liver blood flow contributed as much to the enhanced clearance as did the stimulation of drug metabolism. The mechanism by which phenobarbital produces the frequently observed increase in drug clearance, therefore, depends upon the initial clearance value of the drug. For low clearance drugs like antipyrine, clearance changes occur largely as a result of enzyme induction. With higher clearance drugs, the effects of increased hepatic blood flow become

show abstract

Section: Discussionsupporting

confidence: 91%

Increased Clearance of Antipyrine and d-Propranolol after Phenobarbital Treatment in the Monkey

Branch¹,

Shand²,

Wilkinson³

et al. 1974

J. Clin. Invest.

132

View full text Add to dashboard Cite

show abstract

“…Total hepatic flow is regulated by hepatic artery autoregulation, which means that if portal flow decreases, arterial flow will increase, and vice-versa (5,12). From the sinusoids the blood enters directly into the efferent terminal hepatic veins.…”

mentioning

confidence: 99%

Circulatory disorders of the liver in dogs and cats

Ingh

Rothuizen

Meyer

1995

Veterinary Quarterly

View full text Add to dashboard Cite

“…Active portal venous autoregulation has not been observed in the dog [18] . A myogenic response has been described in arterial resistance vessels that control blood flow in the liver.…”

Section: Cirrhotic Livermentioning

confidence: 89%