Local condiments from fermented tropical legume seeds modulate activities of critical enzymes relevant to cardiovascular diseases and endothelial function

Ademiluyi, Adedayo O.

doi:10.1002/fsn3.582

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…In this case, as shown in Figure 3, all extracts analyzed in this study showed this characteristic of percentage inhibition, with emphasis on the SHE that obtained the highest percentage of inhibition (77.40%). Previous studies with the seed ethanolic extract of P. platycephala and aqueous from P. biglobosa, the latter defatted, confirm iAChE > 50% (Ademiluyi, 2018;Farias et al, 2013). Table 5 shows all the lethal concentrations of 50% of the extracts of P. platycephala.…”

Section: Anticholinesterase Activitymentioning

confidence: 77%

Chemical investigation, toxic potential and acetylcholinesterase inhibitory effect of Parkia platycephala leaf and seed extracts

Fernandes¹,

Rodrigues²,

Panontin³

et al. 2021

J. Med. Plants Res.

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The present work evaluated the inhibitor potential of acetylcholinesterase, the preliminary toxicity and determination of active components of different leaf and seed extracts of Parkia platycephala. All extracts were obtained through hot extraction in a closed system (Soxhlet). To obtain the leaf and seed hexanic, methanolic, and ethanolic extracts (LHE, LME, LEE, and SHE, SME, and SEE), sequential extraction was performed on the same plant sample using hexane, methanol, and hydroethanol solution (70%). Preliminary Phytochemical analysis and the characterization by gas chromatography coupled to the mass spectrometer (GC-MS) was performed. The content of phenols total flavonoids and the antioxidant potential was then quantified.The preliminary toxicity against Artemia salina was also evaluated and the potential for acetylcholinesterase inhibition was determined. The presence of tannins, flavonoids, saponins, phytosterols/triterpenoids and alkaloids were detected in phytochemical analysis. The leaf extracts showed antioxidant potential, LEM (IC 50 = 30.19 ± 0.75 μg/ml) and LEE (IC 50 = 40.62 ± 0.65 μg/ml). The analysis by GC-MS indicated a diversity of volatile compounds, evidencing urs-12-ene (triterpenoid) and 1,2,3-benzenetriol (phenol) in the leaf extracts, and linoelaidic acid (fatty acid), (Z)-9-octadecenamide, tricycle [20.8.0.0 (7.16)] triacontane,1(22),7(16)-diepoxy-, (Z)-7-hexadecenal (fatty aldehyde) in the seed extracts. The preliminary toxicity analysis demonstrated that the use of P. platyceplaha leave and seeds for medicinal purposes is relatively safe. All the extracts inhibited acetylcholinesterase, compared to the physostigmine control, with IC 50 values in the range of 9.85 to 15.68 mg/ml. Thus, these data support the use of P. platycephala as a potential therapy for Alzheimer's disease.

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Section: Anticholinesterase Activitymentioning

confidence: 77%

Chemical investigation, toxic potential and acetylcholinesterase inhibitory effect of Parkia platycephala leaf and seed extracts

Fernandes¹,

Rodrigues²,

Panontin³

et al. 2021

J. Med. Plants Res.

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“…Different parts of P. biglobosa such as seeds, bark, roots and flowers are reportedly used to treat myriads of diseases and ailments [11][12][13]. Scientific findings indicated that the condiments from fermented seeds of P. biglobosa control activities of certain enzymes relevant to cardiovascular diseases and endothelial function [14]. Generally, locust bean tree is used as source of firewood, charcoal and as timber for making pestles, mortars, bows, hoe handles, and seats while the husks and pods are good food for livestock [13,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Climate Change and Fading Genetic Resources of <em>Parkia biglobosa</em> (Jacq.) in Nigeria Based on SSR Markers

Popoola¹,

Agbolade²,

A³

et al. 2019

Preprint

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African locust bean (Parkia biglobosa (Jacq.) is a multi-purpose economic tree with genetic potentials in sub-Saharan Africa. Its cultivation and production is declining with increased aging and genetically threatened throughout its natural ranges. Research efforts are needed to change the present scenario to sustainable cultivation and utilization, hence this present study. This study was aimed at evaluating genetic diversity and geographical spread relationships of twenty landraces collected from different ecological zones of Nigeria using simple sequence repeat (SSR) markers. Ten SSR markers were screened and five primers (PbL02, PbL03, PbL04, PbL05 and PbL09) were selected based on clear amplification products and reproducible scorable bands. The SSR primers detected a total of 55 alleles ranged from 10 to 14 alleles with a mean of 11. The percentage polymorphisms were high and ranged from 68.75 % in PbL04 to 84.21 % in PbL05 with a mean of 74.16 %. The polymorphic information content (PIC) was in the range of 0.31 in PbL02 to 0.37 in PbL09. The genetic diversity and heterozygosity values ranged from 0.39 to 0.50 and 0.00 to 0.68 while the average genetic distance for all pair wise comparisons was 0.31.The first five Principal Component (PC) accounted for 70.20 % of the total variation out of which PC1 (31.50%) and PC2 (19.20%) extracted 49.70% molecular similarity. The dendrogram resulted in separation of the 19 landraces into three major clusters based on unweighted pair group method with arithmetic average. Cluster I comprised of five landraces: ABNo130 and BENo023; OYNo11, KANo125 and NiNo262 while cluster II had only one (BANo116). Cluster III was diverse comprising 13 landraces: ZANo188, KNNo162, KENo220, GMNo076 and EbNo260, ADNo64, EdNo164, KANo137, KENo217, KwNo270, NiNo241, OsNo206 and PLNo120. The homogeneity of alleles among the studied landraces suggested suspicion of loss of genetic intra-specific variation among the landraces of P. biglobosa which calls for concerted efforts toward better cultivation, conservation, management, utilization and genetic improvement of the species in Nigeria.

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Nigerian foods of probiotics relevance and chronic metal exposure: a systematic review

Orisakwe

Amadi

Frazzoli

et al. 2020

Environ Sci Pollut Res

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Local condiments from fermented tropical legume seeds modulate activities of critical enzymes relevant to cardiovascular diseases and endothelial function

Cited by 4 publications

References 42 publications

Chemical investigation, toxic potential and acetylcholinesterase inhibitory effect of Parkia platycephala leaf and seed extracts

Chemical investigation, toxic potential and acetylcholinesterase inhibitory effect of Parkia platycephala leaf and seed extracts

Climate Change and Fading Genetic Resources of <em>Parkia biglobosa</em> (Jacq.) in Nigeria Based on SSR Markers

Nigerian foods of probiotics relevance and chronic metal exposure: a systematic review

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