Local cerebral glucose utilization during chronic infusion of GABA into the nucleus basalis magnocellularis of rats

Majchrzak, Mark J.; Nehlig, Astrid; Will, Bruno

doi:10.1016/0014-4886(92)90005-b

Cited by 2 publications

(1 citation statement)

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“…In a series of experiments, possible longlasting (or irreversible) effects of GABA infusion into the NBM were evaluated. To characterize the spatial extent of the inactivation induced by GABA infusion, Majchrzak et al, (1992b) measured local cerebral metabolic rates for glucose (CMRglc) after 24-h infusions of GABA. The results showed that despite its efficacy on the memory task, infusion of a small dose (10 tg/tL/h) did not modify (in comparison with saline-treated animals) CMRglc within the NBM, in neighboring structures, or in NBM cortical projection areas (frontal and parietal cortex).…”

Section: Gaba and Reversible Inactivationmentioning

confidence: 99%

GABA and Muscimol as Reversible Inactivation Tools in Learning and Memory

Majchrzak

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2000

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Reversible inactivation of brain areas is a useful method for inferring brain-behavior relationships. Infusion of GABA or of the GABA receptor agonist muscimol is considered one interesting reversible inactivation method because it may not affect fibers of passage and may therefore be compared to axon-sparing types of lesions. This article reviews the data obtained with this method in learning and memory experiments. A critical analysis of data, collected in collaboration with Simon Brailowsky, with chronic GABA infusion is presented, together with an illustration of data obtained with muscimol-induced inactivation.

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Section: Gaba and Reversible Inactivationmentioning

confidence: 99%