Local Cellular Responses to Titanium Dioxide from Orthopedic Implants

Yao, Jie; Lewallen, Eric A.; Trousdale, William H.; Xu, Wei; Thaler, Roman; Salib, Christopher G.; Reina, Nicolas; Abdel, Matthew P.; Lewallen, David G.; Wijnen, André J. van

doi:10.1089/biores.2017.0017

Cited by 36 publications

(38 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the field of Orthopaedics, titanium (oxide) wear particles from implants were reported to enter boneforming cells and stem cells via endocytosis and cause adverse biological response including osteolysis [42][43][44][45]. It has also been proposed that titanium particles induce secretion of pro-inflammatory cytokines by fibroblasts, which are involved in the chemotactic migration and recruitment of monocytes/macrophage and subsequently the pathogenesis of aseptic loosening of implants [46].…”

Section: Discussionmentioning

confidence: 99%

Particle release from implantoplasty of dental implants and impact on cells

Barrak

Muntane

et al. 2020

Int J Implant Dent

View full text Add to dashboard Cite

Background With increasing numbers of dental implants placed annually, complications such as peri-implantitis and the subsequent periprosthetic osteolysis are becoming a major concern. Implantoplasty, a commonly used treatment of peri-implantitis, aims to remove plaque from exposed implants and reduce future microbial adhesion and colonisation by mechanically modifying the implant surface topography, delaying re-infection/colonisation of the site. This in vitro study aims to investigate the release of particles from dental implants and their effects on human gingival fibroblasts (HGFs), following an in vitro mock implantoplasty procedure with a diamond burr. Materials and methods Commercially available implants made from grade 4 (commercially pure, CP) titanium (G4) and grade 5 Ti-6Al-4 V titanium (G5) alloy implants were investigated. Implant particle compositions were quantified by inductively coupled plasma optical emission spectrometer (ICP-OES) following acid digestion. HGFs were cultured in presence of implant particles, and viability was determined using a metabolic activity assay. Results Microparticles and nanoparticles were released from both G4 and G5 implants following the mock implantoplasty procedure. A small amount of vanadium ions were released from G5 particles following immersion in both simulated body fluid and cell culture medium, resulting in significantly reduced viability of HGFs after 10 days of culture. Conclusion There is a need for careful evaluation of the materials used in dental implants and the potential risks of the individual constituents of any alloy. The potential cytotoxicity of G5 titanium alloy particles should be considered when choosing a device for dental implants. Additionally, regardless of implant material, the implantoplasty procedure can release nanometre-sized particles, the full systemic effect of which is not fully understood. As such, authors do not recommend implantoplasty for the treatment of peri-implantitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Particle release from implantoplasty of dental implants and impact on cells

Barrak

Muntane

et al. 2020

Int J Implant Dent

View full text Add to dashboard Cite

show abstract

“…The poor water solubility of titanium is often considered as an indicator of its biological inertness. However, studies and case reports of patients with malfunctioning titanium implants reveal a range of adverse effects associated with this metal, including inflammation [49], pain [8], cytotoxicity [50,51], metal allergy [52,53], genotoxicity [54], carcinogenicity [55] and implant failure [56]. The most widely researched effects of titanium are those on the bone cells-osteoblasts (bone-forming) and osteoclasts (bone-resorbing) [42,53,57,58].…”

Section: Adverse Effects Of Titanium Debrismentioning

confidence: 99%

“…Soluble and particulate titanium disturbs the delicate balance between the two cell types, resulting in bone loss and implant loosening, which often necessitates a redo surgery (revision surgery) [35,41,56,[59][60][61]. Formation of large inflammatory masses (pseudotumours) in the vicinity of the implant, originally thought to be an immune response unique to CoCr alloy, was recently linked to titanium release [62][63][64].…”

Section: Adverse Effects Of Titanium Debrismentioning

confidence: 99%

Blood titanium level as a biomarker of orthopaedic implant wear

Swiatkowska

Martin

Hart

2019

Journal of Trace Elements in Medicine and Biology

View full text Add to dashboard Cite

Background: Joint replacement implants are usually manufactured from cobalt-chromium or titanium alloys. After the device is implanted, wear and corrosion generate metal particles and ions, which are released into local tissue and blood. The metal debris can cause a range of adverse local and systemic effects in patients. Research problem: In the case of cobalt and chromium, a blood level exceeding 7 µg L-1 indicates potential for local toxicity, and a failing implant. It has been repeatedly suggested in the literature that measurement of titanium could also be used to assess implant function. Despite an increasing interest in this biomarker, and growing use of titanium in orthopaedics, it is unclear what blood concentrations should raise concerns. This is partly due to the technical challenges involved in the measurement of titanium in biological samples. Aim: This Review summarises blood/serum titanium levels associated with well-functioning and malfunctioning prostheses, so that the prospects of using titanium measurements to gain insights into implant performance can be evaluated. Conclusion: Due to inter-laboratory analytical differences, reliable conclusions regarding "normal" and "abnormal" titanium levels in patients with orthopaedic implants are difficult to draw. Diagnosis of symptomatic patients should be based on radiographic evidence combined with blood/serum metal levels.

show abstract

“…The titanium alloy may impart titanium dioxide nanoparticles, which have been reported to alter the viability and behavior of multiple bone-related cell types, increase bone resorption, and lead to clinical incidents of osteolysis, implant loosening, and joint pain. 46 Thus, for fractures without major tissue deficiencies, SNPT materials may be a more desirable choice for external fixation.…”

Section: Discussionmentioning

confidence: 99%

Using an Engineered Galvanic Redox System to Generate Positive Surface Potentials that Promote Osteogenic Functions

Zhang

Zheng

et al. 2018

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Successful osseointegration of orthopaedic and orthodontic implants is dependent on a competition between osteogenesis and bacterial contamination on the implant–tissue interface. Previously, by taking advantage of the highly interactive capabilities of silver nanoparticles (AgNPs), we effectively introduced an antimicrobial effect to metal implant materials using an AgNP/poly(DL-lactic-co-glycolic acid) (PLGA) coating. Although electrical forces have been shown to promote osteo-genesis, creating practical materials and devices capable of harnessing these forces to induce bone regeneration remains challenging. Here, we applied galvanic reduction–oxidation (redox) principles to engineer a nanoscale galvanic redox system between AgNPs and 316L stainless steel alloy (316L-SA). Characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, atomic force microscopy, Kelvin probe force microscopy, and contact angle measurement, the surface properties of the yield AgNP/PLGA-coated 316L-SA (SNPSA) material presented a significantly increased positive surface potential, hydrophilicity, surface fractional polarity, and surface electron accepting/donating index. Importantly, in addition to its bactericidal property, SNPSA’s surface demonstrated a novel osteogenic bioactivity by promoting peri-implant bone growth. This is the first report describing the conversion of a normally deleterious galvanic redox reaction into a biologically beneficial function on a biomedical metal material. Overall, this study details an innovative strategy to design multifunctional biomaterials using a controlled galvanic redox reaction, which has broad applications in material development and clinical practice.

show abstract

Local Cellular Responses to Titanium Dioxide from Orthopedic Implants

Cited by 36 publications

References 89 publications

Particle release from implantoplasty of dental implants and impact on cells

Particle release from implantoplasty of dental implants and impact on cells

Blood titanium level as a biomarker of orthopaedic implant wear

Using an Engineered Galvanic Redox System to Generate Positive Surface Potentials that Promote Osteogenic Functions

Contact Info

Product

Resources

About