Local, cell-nonautonomous feedback regulation of myosin dynamics patterns transitions in cell behavior: a role for tension and geometry?

Abstract

Signals, stresses, and myosin-dependent contractility influence cell geometry, tension, myosin dynamics, and pulsed constriction in the amnioserosa both cell-autonomously and -nonautonomously and feedback regulate cell behavior. Cell delamination is a locally patterned, nonautonomously regulated transition from pulsed to unpulsed constriction.

Apical constriction: themes and variations on a cellular mechanism driving morphogenesis

“…For example, during dorsal closure in Drosophila, cells of the amnioserosa (an epithelium that occupies the dorsal side of the embryo) undergo apical constriction during late embryogenesis and exhibit dramatic fluctuations in apical areas that are associated with actin-myosin pulses. Laser ablation of apical actin-myosin cortices of individual amnioserosa cells or the mosaic expression of proteins that inhibit contractility inhibit oscillations in neighboring amnioserosa cells (Solon et al, 2009;Saravanan et al, 2013). It has also been shown that, in the Drosophila egg chamber, the periodicity of basal actin-myosin pulses is affected by the strength of cytoskeletonadhesion attachment, with increased attachment strength delaying the time between myosin pulses (He et al, 2010).…”

Actomyosin Pulsing in Tissue Integrity Maintenance during Morphogenesis

“…Another important distinction in discussing actomyosin spatiotemporal dynamics is that between pulses and traveling waves, recently reviewed by (Allard and Mogilner, 2013). These two phenomena are probably related, and sometimes occur together (Munro et al, 2004; Rauzi et al, 2010; Saravanan et al, 2013). We limit this review to a discussion of pulsing.…”

Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer

“…37 Contractile pulsations of junctions were also altered in Drosophila amnioserosa cells that underwent naturally-occurring delamination. 44 Additionally, work on UV-induced apoptosis has also delineated a mechanical role for the extruding cells to initiate extrusion. 43 Here, the actin cytoskeleton at the ZA of the apoptotic cell pulls on its neighbors, to trigger the upregulation of lateral F-actin in those neighbors which expels the apoptotic cell.…”