Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells

Shi, Liyun; Leu, Shaw-Woei; Xu, Feng; Zhou, Xin; Yin, Hongping; Cai, Lei; Zhang, Lihuang

doi:10.1016/j.clim.2008.07.015

Cited by 81 publications

(63 citation statements)

References 45 publications

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“…The allergic inflammation in an animal model of asthma was significantly suppressed in TSLP receptor-deficient mice [7]. In addition, the intratrachial administration of Fc-TSLP receptor-fusion protein or anti-TSLP receptor significantly reduced eosinophil infiltration, hyperplasia, and Th2 cytokine production [7,8]. Lung-specific expression of TSLP induced asthma-like airway inflammation [9], and skin-selective expression and intradermal injection of TSLP induced atopic dermatitis [10,11].…”

Section: Introductionmentioning

confidence: 99%

Induction of Thymic Stromal Lymphopoietin Production by Xylene and Exacerbation of Picryl Chloride-Induced Allergic Inflammation in Mice

Satou¹,

Ishihara

Hiratsuka³

et al. 2011

Int Arch Allergy Immunol

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Background: Some chemical compounds in the environment worsen allergic inflammation. In this study, we examined whether organic solvents induce the production of thymic stromal lymphopoietin (TSLP) which elicits Th2-type immune responses. Methods: Organic solvents were painted on the earlobes of BALB/c mice. The expression of TSLP in the ear was determined by ELISA. Results: Xylene and toluene, but not chloroform or ethyl acetate, induced the expression of mRNA for TSLP in the earlobe tissue. Among the aromatic compounds, xylene, especially m-xylene, and trimethylbenzene caused apparent TSLP production. The level of TSLP in the xylene-treated earlobes reached a maximum at 24 h, and TSLP was expressed in epithelial tissues. Production of TSLP was unaffected in mast cell-deficient W/W^v mice but apparently diminished in TNF-α knockout mice and IL-4 receptor knockout mice. Repeated painting of xylene for 7 days induced an increase in the weight of cervical lymph nodes and expression of OX40 ligand, both of which were inhibited in TSLP receptor knockout mice. Xylene promoted the picryl chloride-induced thickening of the ear and IL-4 production, which were reversed in TSLP receptor knockout mice. Conclusion: Xylene induced TSLP production, resulting in an exacerbation of allergic inflammation. Thus, xylene might be a good tool for examining the roles of TSLP in eliciting allergy in experimental animals.

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Section: Introductionmentioning

confidence: 99%

Induction of Thymic Stromal Lymphopoietin Production by Xylene and Exacerbation of Picryl Chloride-Induced Allergic Inflammation in Mice

Satou¹,

Ishihara

Hiratsuka³

et al. 2011

Int Arch Allergy Immunol

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“…These results indicated that TSLPR plays an important role in the development of inflammatory and/or allergic responses. Shi and coworkers have recently suggested that the local application of anti-TSLPR prevented Th2-mediated airway inflammation by regulating the function of DCs, and this might be exploited to develop novel treatments for asthma (13).…”

Section: Introductionmentioning

confidence: 99%

Identifying the polymorphisms in the thymic stromal lymphopoietin receptor (TSLPR) and their association with asthma

Kang²,

Chun³

et al. 2010

BMB Reports

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The present study aimed to investigate whether the polymorphisms in the TSLPR gene are associated with atopic and asthmatic disease in the Korean population. We identified eleven single nucleotide polymorphisms (SNPs) and two variation sites in the TSLPR gene, including the promoter region. The genotype and allele frequencies of g.33G＞C of the TSLPR gene in asthma patients were significantly different from the respective frequencies of the control group (P = 0.006 and 0.003, respectively). Our additional analysis showed that the genotype and allele frequencies of the g.33G＞C and g.19646A＞G of the TSLPR gene were significantly associated in the atopic asthma patients rather than in the non-atopic asthma patients (genotype frequencies; P = 0.0001 and 0.0003 respectively, allele frequencies; P = 0.0005 and 0.0001 in that order). Our results suggest that the SNPs of the TSLPR gene could be associated with the susceptibility to atopic asthma in the Korean population. [BMB reports 2010; 43(7): 499-505]

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“…Immunosuppressive cytokines such as IL-10 and TGF-β have been implicated in immune regulation by Tregs during airway inflammation. For instance, coexpression of IL-10 and TGF-β by Tregs allowed complete inhibition of airway hyperreactivity [44,45,46]. Activated pulmonary Tregs expressed TSLPR and responded to TSLP-mediated activation of STAT-5 [10].…”

Section: Tslp: Function and Roles In Th2 Immunitymentioning

confidence: 99%

Thymic Stromal Lymphopoietin: A Promising Therapeutic Target for Allergic Diseases

Wang

Zhang

et al. 2012

Int Arch Allergy Immunol

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Thymic stromal lymphopoietin (TSLP), an interleukin 7-like cytokine, can trigger dendritic cell (DC)-mediated T-helper type 2 (Th2) inflammatory responses. Recent evidence demonstrates that cytokines TSLP and OX40 (CD134)/OX40 ligand seem to be important players in the maintenance of Th2 memory pool in the pathogenesis of asthma. Accumulating data reveal that the pathogenic T cells involved in asthma are likely to be inflammatory Th2 cells. TSLP is involved in the development of asthma through crosstalk with nuclear factor NF-ĸB. Progression of skin fibrosis in atopic dermatitis occurs via TSLP/TSLP receptor. TSLP-mediated dermal inflammation aggravates experimental allergic asthma. Also, TSLP polymorphisms are associated with susceptibility to asthma, atopic dermatitis, and eczema herpeticum. These findings suggest a master switch of TSLP in the initiation of allergic and adaptive inflammation through innate pathways at the epithelial cell-DC interface. The TSLP pathway is therefore a promising target for immunotherapy of allergic diseases.

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Local blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cells

Cited by 81 publications

References 45 publications

Induction of Thymic Stromal Lymphopoietin Production by Xylene and Exacerbation of Picryl Chloride-Induced Allergic Inflammation in Mice

Induction of Thymic Stromal Lymphopoietin Production by Xylene and Exacerbation of Picryl Chloride-Induced Allergic Inflammation in Mice

Identifying the polymorphisms in the thymic stromal lymphopoietin receptor (TSLPR) and their association with asthma

Thymic Stromal Lymphopoietin: A Promising Therapeutic Target for Allergic Diseases

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