Local biosynthesis of corticosterone in rat skeletal muscle

Sato, M.; Sugiyama, Kimikazu; Maeda, Naoyuki; Fujiki, Jumpei; Ieko, Takahiro; Kawamura, Yoshio; Iwano, Hidetomo; Mukai, Kuniaki; Yokota, Hiroshi

doi:10.1016/j.jsbmb.2020.105693

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…Corticosterone is known to be secreted by the brain, salivary glands, and skeletal muscles in addition to the adrenal glands. Hence, even if bilateral adrenal glands are removed, the remaining amounts secreted prevent death [49][50][51] . There was little influence of ADx on the expression levels and rhythms of Bmal1, Per2, or Rev-erbα in both the liver and the bladder except that the peak of Rev-erbα expression increased significantly in the liver of ADx mice compared to sham mice (Fig.…”

Section: Resultsmentioning

confidence: 99%

Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice

et al. 2023

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Peripheral clocks function to regulate each organ and are synchronized though various molecular and behavioral signals. However, signals that entrain the bladder clock remain elusive. Here, we show that glucocorticoids are a key cue for the bladder clock in vitro and in vivo. A pBmal1-dLuc human urothelial cell-line showed significant shifts in gene expression after cortisol treatment. In vivo, rhythmic bladder clock gene expression was unchanged by bilateral adrenalectomy but shifted 4 h forward by corticosterone administration at the inactive phase. Moreover, the bladder clock shifted 8–12 h in mice that underwent both bilateral adrenalectomy and corticosterone administration at the inactive phase. These mice showed decreases in the diurnal rhythm of volume voided per micturition, while maintaining diurnal activity rhythms. These results indicate that the diurnal rhythm of glucocorticoid signaling is a zeitgeber that overcomes other bladder clock entrainment factors and coordinates the diurnal rhythm of volume voided per micturition.

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Section: Resultsmentioning

confidence: 99%