Local Application of Prostaglandin E2 for Cervical Ripening or Induction of Term Labor

Ulmsten, Ulf; Wingerup, L.; Ekman, Gunvor

doi:10.1097/00003081-198303000-00013

Cited by 49 publications

(22 citation statements)

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“…Our study corroborates the findings of Ulmstein et al [7] and Shepherd et al [8] that intracervical PGE2 gel results in improvement of cervical score facilitating oxytocin initiation of labour and often initiates labour per se. The improvement of cervical score from a mean of 2.1 to 6.8 in primigravidas and from mean of 2.5 to 7.3 in multigravidas 12 hours after PGE2 gel application intracervically is similar to that observed by Trofatter et al [9].…”

Section: Discussionsupporting

confidence: 92%

“…Trofatter et al had also observed a mean induction delivery interval of 13.3 hours. Our findings are at variance with that of Ulmsten and coworkers [7] who reported only 53% of delivery in first 24 h but similar to Mishra reporting delivery rate of 73.8% among primigravidas in the PGE2 intracervically treated group within first 24 h [10]. Our policy of selectively augmenting labour as of Mishra et al accounted for our high success rates [10].…”

Section: Discussionsupporting

confidence: 60%

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Comparison of Intracervical Prostaglandin E2 and Intravenous Oxytocin in Induction of Labour

Bhattacharyya

Shandil

1998

Medical Journal Armed Forces India

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154 patients requiring induction with unfavourable cervix at varying period of gestation were studied. Patients were distributed into two groups. 76 patients were induced with 0.5 mgm single dose intracervical application of Prostaglandin E2 gel and remaining 78 patients with Oxytocin and efficacy of the two methods of induction was compared. Labour was established within 24 hours in 71.4% of primigravidas and 91.7% of multigravidas in the prostaglandin treated group compared to 65.6% of primigravidas and 89.1% of multigravidas in the oxytocin group. The study found substantial improvement in cervical score 12 hours after application of intracervical prostaglandin E2 gel and decrease in Caesarean section rate with no major adverse effect to mother or neonate. MJAFI 1998; 54 : 225-228

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 60%

Comparison of Intracervical Prostaglandin E2 and Intravenous Oxytocin in Induction of Labour

Bhattacharyya

Shandil

1998

Medical Journal Armed Forces India

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“…Intracervical PGE? administration is better than the intravaginal route, since the active substance reaches the target organ directly, absorption into the sys temic circulation is less rapid, and the doses needed are 5-to 10-fold lower, thereby avoiding the side effects of PGs [7][8][9], However, the optimal dose of intracervical PGE? gel for cervical ripening and labor induction has not yet been defined.…”

Section: Introductionmentioning

confidence: 99%

Intracervical Prostaglandin E<sub>2</sub> Gel for Cervical Ripening and Labor Induction: What Is the Appropriate Dose?

Minaretzis

Tsionou²,

Papageorgiou³

et al. 1993

Gynecol Obstet Invest

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In order to evaluate a dose-related response of cervical ripening and labor induction to a prostaglandin E₂ (PGE₂) gel, 110 women with uncomplicated postdate pregnancies and unripe cervices received intracervically 0.5 mg PGE₂ (n = 40), 1.5 mg PGE₂ (n = 35) or 2.5 mg PGE₂ (n = 35). The failure rate in terms of cervical ripening was similar in all groups. Labor characteristics such as the duration of the latent phase as well as the total length of labor, the cesarean-section rate, instrumental deliveries and neonatal outcome were similar in all groups. The number of women who required oxytocin for labor augmentation was negatively correlated to the dose of PGE₂ (p < 0.05). In addition, 3 out of 35 women in the 2.5-mg group presented hypertonic uterine activity. The increase in the dose of PGE₂ gel did not increase the possibility for a vaginal delivery, but reduced the requirement for oxytocin while increasing hypertonic uterine action.

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“…The optimal regimen for preinduction cervical ripening and labor induction has not been established. Although local application of prostaglandin E2 (PGE2) has been considered effective for cervical ripening and shortening delivery time (2,3), this procedure is very expensive and thus unavailable to obstetricians in many developing or underdeveloped countries. Oxytocin is the agent most frequently used for the induction of labor (4,5).…”

Section: Introductionmentioning

confidence: 99%

Labor induction: comparison between oxytocin and dinoprostone

Yurtsever¹,

Cengiz²,

Yurtsever³

et al. 2013

Gaziantep Med J

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Labor induction is one of the most frequent procedures in pregnant women. The optimal regimen for preinduction cervical ripening and labor induction is not established. The aim of the present study was to compare the efficacy and safety of vaginal dinoprostone and intravenous oxytocin administration for labor induction. The medical records of the patients who had induction of labor at Okmeydanı Teaching and Research Hospital, Department of Obstetrics and Gynecology from January 2010 to June 2011 were evaluated retrospectively. The first group (143 patients) received a single dose of sustained-released dinoprostone 10 mg, which was inserted high into the vaginal fornix. The second group (151 patients) received intravenous oxytocin (synpitan). Maternal and fetal outcomes were compared. There were no significant differences between the two groups for parity, birth weight, fetal gender and mode of delivery. 195 (66.3%) of patiens had vaginal delivery and 99 (33.7%) had cesarean delivery. The median time from start of induction of labor to vaginal birth was longer when a prostaglandin E2 was used for labor induction than it was when oxytocin was used (20.1 hours vs 16.1 hours) (p<0.01). No maternal death or uterine rupture occurred. Neonatal weight, admission to neonatal unit, 1 and 5-minute Apgar score <7, did not differ significantly between two groups (p>0.05). Oxytocin is safe, effective and cost-effective treatment. The current study shows that sustained-released Dinoprostone which is an FDA (U.S. Food and Drug Administration) approved drug; is an alternative method for the induction of labor although it is not cost effective. Keywords: Cervical ripening; dinoprostone; labor induction; oxytocin. Özet

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Local Application of Prostaglandin E2 for Cervical Ripening or Induction of Term Labor

Cited by 49 publications

References 0 publications

Comparison of Intracervical Prostaglandin E2 and Intravenous Oxytocin in Induction of Labour

Comparison of Intracervical Prostaglandin E2 and Intravenous Oxytocin in Induction of Labour

Intracervical Prostaglandin E<sub>2</sub> Gel for Cervical Ripening and Labor Induction: What Is the Appropriate Dose?

Labor induction: comparison between oxytocin and dinoprostone

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