Introduction Orthognathic surgery involves making several osteotomies. Any osteotomies leads to varying degrees of post-operative swelling. The aim of this study was to evaluate the effectiveness of anti-edema drugs for the control of edema, using Digitizer 3D TM for measuring softtissue thickness, in patients who underwent bimaxillaryorthognathic surgery. Materials and Methods In this double-blinded, randomized, control trial, 24 patients (study group: 12 patients, control group: 12 patients) in whom bimaxillary orthognathic surgery was indicated, were included in this study. All swelling measurements were expressed as total 3-D area of the landmarks (cm 2 ) in T0 pre-operative, T1 first day after surgery, T2 fourth day after surgery, T3 4 months after surgery. For each patient we compared, by adding left and right area, the increase of swelling between T1-T0, T2-T0 and T1-T3. Results The differences T0-T1 are highly significant (p \ 0.01) between group 1 or study group (treated with Venoplant Ò ) and group 2 (control group); the differences T0-T2 are significant (p \ 0.05) between group 1 (treated with Venoplant Ò ) and group 2 (control group). The differences T1-T3 are significant (p \ 0.05) between group 1 (treated with Venoplant Ò ) and group 2 (control group). Discussion The present study suggests that Venoplant Ò significantly decreases postoperative edema in orthognathic surgery, thus precluding long-term corticosteroid use.