Local Anesthetics in Lipid-Depot Formulations—Neurotoxicity in Relation to Duration of Effect in a Rat Model

Dyhre, Henrik; Söderberg, Lars; Björkman, Sven; Carlsson, Christer

doi:10.1097/00115550-200609000-00002

Cited by 17 publications

(1 citation statement)

References 32 publications

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“…Some authors 2 have shown that higher concentrations of lidocaine and bupivacaine (BP) promote longer-lasting blockade of the sciatic nerves of rats; however, these concentrations are clearly neurotoxic in histopathological analysis.…”

Section: Introductionmentioning

confidence: 99%

Análise do potencial citotóxico agudo da bupivacaína e bupivacaína em excesso enantiomerico de 50% (S75-R25) incorporadas a microesferas sobre o nervo ciático de ratos

Tanaka

Torres

Tenório

2012

Rev. Bras. Anestesiol.

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Summary: Tanaka PP, Torres MF, Tenorio SB -Analysis of the Acute Cytotoxic Potential of Bupivacaine and 50% Enantiomeric Excess Bupivacaine (S75-R25) Incorporated into Microspheres in Rat Sciatic Nerves. Background and objectives:The duration of Local Anesthetic (LA) effects can be expanded by its incorporation into systems of sustained release microspheres. However, the possibility that LA sustained release systems are neurotoxic has not received due attention in literature. The objective of this study was to investigate the effects of pure microspheres of poly(lactic-co-glycolic acid), filled with 50% enantiomeric excess bupivacaine or bupivacaine (BP), as well as the effects of 50% enantiomeric excess bupivacaine in the sciatic nerve of Wistar rats.

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Section: Introductionmentioning

confidence: 99%

Análise do potencial citotóxico agudo da bupivacaína e bupivacaína em excesso enantiomerico de 50% (S75-R25) incorporadas a microesferas sobre o nervo ciático de ratos

Tanaka

Torres

Tenório

2012

Rev. Bras. Anestesiol.

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Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier

et al. 2016

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Efeitos de dexmedetomidina perineural no nervo ciático em ratos

Yektaş

Çabalar

Sar

et al. 2017

Brazilian Journal of Anesthesiology

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The present study was designed to test the hypothesis that high dose dexmedetomidine would increase the duration of antinociception to a thermal stimulus in a rat model of sciatic nerve blockade without causing nerve damage. The rats were anesthetized with isoflurane. After electromyography (EMG) recordings, right sciatic nerves were explored and perineural injections were delivered: Group D (n=7), 40μgμgkg dexmedetomidine administration, Group II (n=6), (0.2mL) saline administration, Group III (n=2), only surgically exploration of the right sciatic nevre. Time to paw withdrawal latency (PAW) to a thermal stimulus for both paws and an assessment of motor function were measured every 30min after the nerve block until a return to baseline. The compound muscle action potential (CMAP) of right and left sciatic nerves were recorded 10 times per each nerve once more after perineural injections at 14 day. After EMG recordings, right and the part of left sciatic nerve were excised at a length of at minimum 15mm for histopathological examination. Comparison of right/left CMAP amplitude ratios before and 14 days after the procedure showed a statistically significant difference (p=0.000). There were no differences in perineural inflammation between the Group D, Group S, and Group E at 14 days.

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Local Anesthetics in Lipid-Depot Formulations—Neurotoxicity in Relation to Duration of Effect in a Rat Model

Cited by 17 publications

References 32 publications

Análise do potencial citotóxico agudo da bupivacaína e bupivacaína em excesso enantiomerico de 50% (S75-R25) incorporadas a microesferas sobre o nervo ciático de ratos

Análise do potencial citotóxico agudo da bupivacaína e bupivacaína em excesso enantiomerico de 50% (S75-R25) incorporadas a microesferas sobre o nervo ciático de ratos

Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier

Efeitos de dexmedetomidina perineural no nervo ciático em ratos

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