Local and systemic coagulation marker response to musculocutaneous flap ischemia–reperfusion injury and remote ischemic conditioning: An experimental study in a porcine model

Krag, Andreas Engel; Hvas, Christine Lodberg; Kiil, Birgitte Jul; Eschen, Gete Ester Toft; Damsgaard, Tine Engberg; Hvas, Anne‐Mette

doi:10.1002/micr.30287

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…Finally, RIPC did not influence thrombin generation or secondary hemostasis markers in the present study. In a porcine model, we have shown that remote ischemic conditioning increased ETP but also aPTT during the reperfusion phase of tissue flap ischemia-reperfusion injury [27]. In human studies, remote ischemic conditioning did not influence thrombin generation in healthy men with no ischemic event [26].…”

Section: Discussionmentioning

confidence: 99%

Effect of remote ischemic preconditioning on hemostasis and fibrinolysis in head and neck cancer surgery: A randomized controlled trial

et al. 2019

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Introduction The aim of this randomized controlled trial was to investigate if remote ischemic preconditioning (RIPC) reduced platelet aggregation and increased fibrinolysis in cancer patients undergoing surgery and thereby reduced the risk of thrombosis. Materials and methods Head and neck cancer patients undergoing tumor resection and microsurgical reconstruction were randomized 1:1 to RIPC or sham intervention. RIPC was administered intraoperatively with an inflatable tourniquet by four cycles of 5-min upper extremity occlusion and 5-min reperfusion. The primary endpoint was collagen-induced platelet aggregation measured with Multiplate as area-under-the-curve on the first postoperative day. Secondary endpoints were markers of primary hemostasis, secondary hemostasis, and fibrinolysis. Clinical data on thromboembolic and bleeding complications were prospectively collected at 30-day follow-up. An intention-to-treat analysis was performed. Results Sixty patients were randomized to RIPC (n = 30) or sham intervention (n = 30). No patients were lost to follow-up. The relative mean [95% confidence interval] collagen-induced platelet aggregation was 1.26 [1.11;1.40] in the RIPC group and 1.17 [1.07;1.27] in the sham group on the first postoperative day reported as ratios compared with baseline ( P = 0.30). Median (interquartile range) 50% fibrin clot lysis time was 517 (417–660) sec in the RIPC group and 614 (468–779) sec in the sham group ( P = 0.25). The postoperative pulmonary embolism rate did not differ between groups ( P = 1.0). Conclusions RIPC did not influence hemostasis and fibrinolysis in head and neck cancer patients undergoing surgery. RIPC did not reduce the rate of thromboembolic complications.

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Section: Discussionmentioning

confidence: 99%

Effect of remote ischemic preconditioning on hemostasis and fibrinolysis in head and neck cancer surgery: A randomized controlled trial

et al. 2019

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“… 8 The mechanisms of this remote response to injury/reperfusion are related to microvascular dysfunction. 9 , 10 , 11 In our research, slight kidney damage was highly suspected due to increased blood urea nitrogen and serum creatinine concentration. Lastly, we did not use the SJT shoulder straps at the axilla in the swine model.…”

Section: Discussionmentioning

confidence: 61%

Effect of SAM junctional tourniquet on respiration when applied in the axilla: A swine model

Zhao¹,

Zhang²,

Yu³

et al. 2023

Chinese Journal of Traumatology

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Deleterious Effects of Remote Ischaemic Per-conditioning During Lower Limb Ischaemia–Reperfusion in Mice

Guillot¹,

Charles²,

Lejay³

et al. 2021

European Journal of Vascular and Endovascular Surgery

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Local and systemic coagulation marker response to musculocutaneous flap ischemia–reperfusion injury and remote ischemic conditioning: An experimental study in a porcine model

Abstract: The local coagulation marker response to musculocutaneous flap ischemia-reperfusion could be measured systemically by moderate hypercoagulation. RIC did not substantially influence coagulation markers following musculocutaneous flap ischemia-reperfusion injury.

Cited by 6 publications

References 24 publications

Effect of remote ischemic preconditioning on hemostasis and fibrinolysis in head and neck cancer surgery: A randomized controlled trial

Effect of remote ischemic preconditioning on hemostasis and fibrinolysis in head and neck cancer surgery: A randomized controlled trial

Effect of SAM junctional tourniquet on respiration when applied in the axilla: A swine model

Deleterious Effects of Remote Ischaemic Per-conditioning During Lower Limb Ischaemia–Reperfusion in Mice

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