Local and Systemic Antibiotics in Peri-Implantitis Management: An Umbrella Review

Boccia, Giovanni; Spirito, Federica Di; D'Ambrosio, Francesca Romana; Palo, Maria Pia Di; Giordano, Francesco; Amato, Massimo

doi:10.3390/antibiotics12010114

Cited by 32 publications

(31 citation statements)

References 60 publications

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“…Plaque removal on implant-supported prostheses is an important long-term prognostic factor for maintenance and stability of dental implants and for the prevention of biological complications [108].…”

Section: Clinical Advice On Cleaning and Disinfection Practices For I...mentioning

confidence: 99%

“…The 2017 World Workshop Consensus report on periodontal and peri-implant conditions defined peri-implant mucosa as healthy when there is not erythema, bleeding on probing, swelling, or suppuration, while defining peri-implant mucositis as the presence of clinical inflammation, and peri-implantitis as the additional presence of progressive bone loss [108].…”

Section: Clinical Advice On Cleaning and Disinfection Practices For I...mentioning

confidence: 99%

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Characterization of the Oral Microbiome in Wearers of Fixed and Removable Implant or Non-Implant-Supported Prostheses in Healthy and Pathological Oral Conditions: A Narrative Review

et al. 2023

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Oral commensal microorganisms perform very important functions such as contributing to the health of the host. However, the oral microbiota also plays an important role in the pathogenesis and development of various oral and systemic diseases. The oral microbiome may be characterized by a higher prevalence of some microorganisms than others in subjects with removable or fixed prostheses, depending on oral health conditions, the prosthetic materials used, and any pathological conditions brought about by inadequate prosthetic manufacturing or poor oral hygiene. Both biotic and abiotic surfaces of removable and fixed prostheses can be easily colonized by bacteria, fungi, and viruses, which can become potential pathogens. The oral hygiene of denture wearers is often inadequate, and this can promote oral dysbiosis and the switch of microorganisms from commensal to pathogens. In light of what emerged from this review, fixed and removable dental prostheses on teeth and on implants are subject to bacterial colonization and can contribute to the formation of bacterial plaque. It is of fundamental importance to carry out the daily hygiene procedures of prosthetic products, to design the prosthesis to facilitate the patient’s home oral hygiene practices, and to use products against plaque accumulation or capable of reducing oral dysbiosis to improve patients’ home oral practices. Therefore, this review primarily aimed to analyze the oral microbiome composition in fixed and removable implant or non-implant-supported prostheses wearers in healthy and pathological oral conditions. Secondly, this review aims to point out related periodontal self-care recommendations for oral dysbiosis prevention and periodontal health maintenance in fixed and removable implant or non-implant-supported prostheses wearers.

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Section: Clinical Advice On Cleaning and Disinfection Practices For I...mentioning

confidence: 99%

Section: Clinical Advice On Cleaning and Disinfection Practices For I...mentioning

confidence: 99%

Characterization of the Oral Microbiome in Wearers of Fixed and Removable Implant or Non-Implant-Supported Prostheses in Healthy and Pathological Oral Conditions: A Narrative Review

et al. 2023

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“…Antibiotic-loaded systems remain a relevant approach, however, care should be taken to avoid bacterial resistance effects. For example, systemic administration of antibiotics poses a significantly higher risk of AMR development than localised delivery [344]. Therefore, smart-releasing systems will receive privileged attention in the future, so as to release the right dose (limitation of dosage allowed) at the right place (local instead of systemic delivery) and at the right time (possibly through stimuli-responsive approaches).…”

Section: Future Perspectivesmentioning

confidence: 99%

Biomaterial strategies to combat implant infections: new perspectives to old challenges

Braem

Kamarudin

Bhaskar

et al. 2023

International Materials Reviews

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Peri-implant infection is rapidly becoming anif not the mostimportant clinical challenge for indwelling medical devices. To alleviate the global rise in antibiotic use for the treatment of such infections, a plethora of biomaterials/bioengineering-based antimicrobial strategies are emerging to restrict or ideally to eliminate microbial adhesion and biofilm formation on implant surfaces. Yet, the development of such approaches faces specific challenges, like biocompatibility concerns, reduced antimicrobial effectiveness, long-term stability issues and antibiotic resistance development, which limit translation to the clinic. This review provides insights into the antimicrobial activity of current state-of-the-art biomaterial-based approaches to address the aforementioned issues. Translational research strategies and regulatory framework are also emphasised as key elements facilitating clinical implementation of anti-infective biomaterials. This review closes with the vision that the integration of computational tools and experimental databases using artificial intelligence (AI) would provide new insights for the accelerated development of next-generation biomaterial-based antimicrobial strategies.

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“…Periodontitis and periimplantitis have a bacterial etiology, so it is interesting to understand the antibacterial efficacy of ozone, used in different formulations, alone or in combination with scaling and root planing (SRP) [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Is Ozone a Valid Adjuvant Therapy for Periodontitis and Peri-Implantitis? A Systematic Review

D'Ambrosio

Caggiano

Acerra

et al. 2023

JPM

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Introduction: Ozone is a naturally occurring unstable compound with three oxygen atoms that generally transforms into an oxygen molecule, releasing one oxygen atom. This feature has been exploited in dentistry for numerous applications, including for periodontal diseases and peri-implantitis. Methods: This review was performed in relation to the PRISMA flow chart and was annotated in the PROSPERO register. PICO questions were used as research questions. The risk of bias in the non-randomized clinical trials was appraised using the ROBINS-I tool. Results: An electronic search found a total of 1073 records, in particular, 842 from MEDLINE/PubMed, 13 from Bio Med Central, 160 from Scopus, 1 from the Cochrane library databases, and 57 from the PROSPERO register. A total of 17 studies were included in the present systematic review. Information regarding the characteristics of the periodontal clinical and radiographic parameters for gaseous ozone, ozonate water, ozonate oil, and ozone gel, including clinical attachment loss (CAL) probing depth (PPD), bleeding on probing (BoP), plaque index (PI), gingival index (GI), and marginal bone levels (MBL), were obtained. Conclusions: The studies included in this systematic review show different results regarding the ozone in periodontal treatment in association with or without SRP.

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Local and Systemic Antibiotics in Peri-Implantitis Management: An Umbrella Review

Cited by 32 publications

References 60 publications

Characterization of the Oral Microbiome in Wearers of Fixed and Removable Implant or Non-Implant-Supported Prostheses in Healthy and Pathological Oral Conditions: A Narrative Review

Characterization of the Oral Microbiome in Wearers of Fixed and Removable Implant or Non-Implant-Supported Prostheses in Healthy and Pathological Oral Conditions: A Narrative Review

Biomaterial strategies to combat implant infections: new perspectives to old challenges

Is Ozone a Valid Adjuvant Therapy for Periodontitis and Peri-Implantitis? A Systematic Review

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