Local and systemic alterations in cyclic 3′,5′ AMP phosphodiesterase activity in relation to tail regeneration under hypothyroidism and T4 replacement in the lizard,Mabuya carinata

Ramachandran, A. V.; Swamy, M.S.; Kurup, Anju

doi:10.1002/(sici)1098-2795(199609)45:1<48::aid-mrd7>3.0.co;2-s

Cited by 8 publications

(1 citation statement)

References 21 publications

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“…Consequently, this system would be highly effective at responding promptly to a number of stimulations, promoted by nervous signaling, microarchitectural remnants of destroyed tissues, metabolites of energy generating processes, peptide growth factors, etc. (7)(8)(9). Physiologically, in the endocrine pancreas, hormone-producing cells that are at the end of their life span should be continuously, albeit quite slowly, replaced by newly generated cells.…”

Section: Does the Elusive Pancreatic Stem Cell Exist?mentioning

confidence: 99%

Regeneration of the pancreatic β cell

Trucco¹

2005

J. Clin. Invest.

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Type 1 diabetes is the result of an autoimmune attack against the insulin-producing β cells of the endocrine pancreas. Current treatment for patients with type 1 diabetes typically involves a rigorous and invasive regimen of testing blood glucose levels many times a day along with subcutaneous injections of recombinant DNA-derived insulin. Islet transplantation, even with its substantially improved outcome in recent years, is still not indicated for pediatric patients. However, in light of the fact that some regenerative capabilities of the endocrine pancreas have been documented and recent research has shown that human ES cell lines can be derived in vitro, this review discusses whether it is practical or even possible to combine these lines of research to more effectively treat young diabetic patients.

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Section: Does the Elusive Pancreatic Stem Cell Exist?mentioning

confidence: 99%