Local and sustained delivery of 5‐fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma

Menei, Philippe; Venier, Marie‐Claire; Gamelin, E.; Saint‐André, Jean‐Paul; Hayek, Gemma; Jadaud, É.; Fournier, Dominique; Mercier, Philippe; Guy, Gilles; Benoı̂t, Jean-Pierre

doi:10.1002/(sici)1097-0142(19990715)86:2<325::aid-cncr17>3.3.co;2-j

Cited by 21 publications

(33 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 5‐FU doses and injected volumes were the same regardless of tumor size and were determined from another pilot study of perioperative microsphere injection after tumor resection 27. No acute intracranial hypertension was observed despite the intratumoral injection of 2.5 mL of microsphere suspension, sometimes in large tumors.…”

Section: Discussionmentioning

confidence: 99%

“…In the blood samples, traces of 5‐FU were detected in some patients at Day 10 and Day 20. Compared with the 5‐FU kinetic study that was conducted after perioperative implantation of microspheres into the wall of resected tumor cavities,27 the concentrations of 5‐FU in the CSF and the systemic circulation were in the same range (from 0 ng/mL to 25 ng/mL). There was no correlation between the 5‐FU concentration and the neurologic side effects observed.…”

Section: Discussionmentioning

confidence: 99%

“…Implanted by stereotaxy, these 5‐FU‐releasing microspheres improved the survival of C6, 9L, and F98 glioma‐bearing rats 21, 23–26. Based on these results, a Phase I trial was conducted in patients with newly diagnosed glioblastoma 27. The rationale for this approach was to prevent the preferential recurrence of glioblastoma from the brain parenchyma near the resection site.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Stereotaxic implantation of 5‐fluorouracil‐releasing microspheres in malignant glioma

Menei

Jadaud

Faisant

et al. 2004

Cancer

Self Cite

View full text Add to dashboard Cite

BACKGROUND The authors developed a new method of drug delivery into the brain using implantable, biodegradable microspheres. The strategy was evaluated initially to provide localized and sustained delivery of the radiosensitizer 5‐fluorouracil (5‐FU) after patients underwent surgical resection of malignant glioma. In this study, the microspheres were implanted by stereotaxy into deeply situated and inoperable brain tumors. METHODS Ten patients with newly diagnosed, inoperable, malignant gliomas were included in the study, and 1 dose of 5‐FU was studied (132 mg). After histologic confirmation, a suspension of poly(D‐L lactide‐co‐glycolide) 5‐FU‐loaded microspheres was implanted by stereotaxy into the tumor in one or several trajectories with one to seven deposits per trajectory. External beam radiation (59.4 grays) was started before postoperative Day 7. Patients were followed by clinical examination, computed tomography scanning, magnetic resonance imaging, and 5‐FU assays in blood and cerebrospinal fluid (CSF). RESULTS The number of trajectories was adapted to the size and shape of the tumor. Microsphere implantation was tolerated well, except in four patients who received a single trajectory and experienced a transitory worsening of preexisting neurologic symptoms. There were no episodes of edema or hematologic complications. 5‐FU was detected in CSF and blood in some patients at very low concentrations. The median overall survival was 40 weeks, with 2 patients who had longer survival (71 weeks and 89 weeks, respectively). CONCLUSIONS In this study, the authors demonstrated that biodegradable microspheres could be implanted by stereotaxy and were efficient systems for drug delivery into brain tumors. This method may have future applications in the treatment of patients other malignancies. Cancer 2004;100:405–10. © 2003 American Cancer Society.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Stereotaxic implantation of 5‐fluorouracil‐releasing microspheres in malignant glioma

Menei

Jadaud

Faisant

et al. 2004

Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…Second, heat and pressure are required to fabricate these depots in order to anneal and mold materials to a desired shape which may affect the stability of drugs especially gene, protein or hormone. Polymeric microspheres are also used as drug delivery systems for brain cancer chemotherapy [3,4]. However, fabrication of these particles is difficult to control size and porosity.…”

Section: Introductionmentioning

confidence: 99%

Preparation of self-solidifying polymeric depots from PLEC-PEG-PLEC triblock copolymers as an injectable drug delivery system

et al. 2012

View full text Add to dashboard Cite

Copolymers of (D,L-lactide-random-ε-caprolactone)-block-poy(ethylene glycol)-block-(D,L-lactide-random-ε-caprolactone) or PLEC were explored as materials for injectable drug delivery system. A series of six PLECs were successfully synthesized with varied D,L-lactide (LA) content (0, 10 and 20%) and molecular weight (20 and 50 kDa). All polymers were able to form depots with more than 90% encapsulation efficiency of trypan blue leading to the loading density as high as 27% w/w. The variation of trypan blue loading, LA content and molecular weight were found to have profound effects on trypan blue release profiles. Even though, GPC and SEM confirmed the higher degradation of PLEC chains, trypan blue release rate and burst release was greater as the content of hydrophilic moiety, i.e. LA, was decreased. This was primarily due to the smooth and dense surface and cross-section of PLEC depots. The results from this study suggest a possible application of these depots as injectable, self-solidifying drug delivery systems.

show abstract

“…As an example of implantable devices, poly (lactic acid-co-glycolic acid) (PLGA) microspheres have been studied to deliver 5-fluorouracil (5-FU), which is a hydrophilic and antimetabolite drug used for cancer treatment [Menei 1999[Menei , 2004. After surgical resection of the tumor, 5-fluorouracil (5-FU) loaded PLGA microspheres are implanted intracranially to extend therapeutic duration and to avoid systemic toxicity around brain tissue.…”

Section: Local Drug Delivery Systemsmentioning

confidence: 99%

Chitosan/Ellagic Acid Composite Materials for Local Cancer Therapy

Kim¹

View full text Add to dashboard Cite

Local and sustained delivery of 5‐fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma

Cited by 21 publications

References 0 publications

Stereotaxic implantation of 5‐fluorouracil‐releasing microspheres in malignant glioma

Stereotaxic implantation of 5‐fluorouracil‐releasing microspheres in malignant glioma

Preparation of self-solidifying polymeric depots from PLEC-PEG-PLEC triblock copolymers as an injectable drug delivery system

Chitosan/Ellagic Acid Composite Materials for Local Cancer Therapy

Contact Info

Product

Resources

About