Local and Sustained Baricitinib Delivery to the Skin through Injectable Hydrogels Containing Reversible Thioimidate Adducts
Leo L. Wang,
Spencer Tuohy,
Karen L. Xu
et al.
Abstract:Janus kinase (JAK) inhibitors are approved for many dermatologic disorders, but their use is limited by systemic toxicities including serious cardiovascular events and malignancy. To overcome these limitations, injectable hydrogels were engineered for the local and sustained delivery of baricitinib, a representative JAK inhibitor. Hydrogels were formed via disulfide crosslinking of thiolated hyaluronic acid macromers. Dynamic thioimidate bonds were introduced between the thiolated hyaluronic acid and nitrile‐c… Show more
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