Local and national electronic databases in Norway demonstrate a varying degree of validity

Lofthus, C. M.; Cappelen, Inger; Osnes, E.; Falch, Jan A.; Kristiansen, Ivar Sønbø; Medhus, Asle W.; Nordsletten, Lars; Meyer, Haakon E

doi:10.1016/j.jclinepi.2004.07.003

Cited by 49 publications

(49 citation statements)

References 30 publications

(53 reference statements)

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“…25,26 For this analysis, we used the ICD-10 codes for femoral neck fracture (S72.0) and intertrochanteric fracture (S72.1). 27,28 Case-control studies do not readily yield estimates of excess risk. We therefore estimated the attributable fraction among exposed women, defined as the fraction of exposed cases that might have been avoided had the exposure not occurred, using the formula AF e = (OR−1)/OR.…”

Section: Discussionmentioning

confidence: 99%

Bisphosphonate Use and the Risk of Subtrochanteric or Femoral Shaft Fractures in Older Women

Park-Wyllie

Mamdani²,

Juurlink³

et al. 2011

JAMA

377

239

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Section: Discussionmentioning

confidence: 99%

Bisphosphonate Use and the Risk of Subtrochanteric or Femoral Shaft Fractures in Older Women

Park-Wyllie

Mamdani²,

Juurlink³

et al. 2011

JAMA

377

239

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show abstract

“…Another potential source of inaccuracy is the potential to duplicate patient numbers because of recurrent admissions to or transfer between hospitals for a single hip fracture episode. Lofthus et al reviewed the Norwegian patient register and noted a 19% overestimation of hip fractures, and this was attributed in part to such multiple admissions [25]. Similarly, Brophy et al highlighted inaccuracies produced by methodological search techniques of national databases [26].…”

Section: Discussionmentioning

confidence: 99%

Incidence of hip fracture in the Republic of Ireland and future projections: a population-based study

et al. 2009

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“…Plasma samples for determination of folate and vitamin B 12 levels had been stored for up to 10 years before analyses, and this may have led to weakening of associations. (28) Because the validity of hospital discharge diagnoses have been questioned, (40) we included only the first hip fracture diagnosis, validated by a concurrent code of an adequate surgical procedure. This should reduce the overestimation of fractures related to rehospitalizations, transferals, or miscoding.…”

Section: Discussionmentioning

confidence: 99%

Plasma Homocysteine, Folate, and Vitamin B12 and the Risk of Hip Fracture: The Hordaland Homocysteine Study

Gjesdal

Vollset

Ueland

et al. 2007

Journal of Bone and Mineral Research

138

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Homocysteine and related factors were evaluated as risk factors for subsequent hip fractures among 4766 elderly men and women. High levels of homocysteine and low levels of folate predicted fracture, whereas vitamin B 12 and genotypes were not related to fracture risk. High homocysteine may be a modifiable risk factor for hip fracture.Introduction: Elevated plasma total homocysteine (tHcy) and deficiencies of folate and vitamin B 12 are associated with risk of osteoporosis and fracture. We examined whether plasma levels of tHcy, folate, and vitamin B 12 and the methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298C→T polymorphisms predicted hip fracture. Materials and Methods:This was a population-based prospective study of 2639 women and 2127 men who were 65-67 yr at enrollment in 1992-1993. Information on hip fracture was obtained from computerized records of discharge diagnoses from all hospitalizations in the region in the period between enrollment and November 30, 2005. Cox proportional hazard regression was used to estimate fracture risk according to levels of plasma tHcy, folate, and vitamin B 12 and for different genotypes. Results: Over a median follow-up period of 12.6 yr, hip fracture was recorded in 184 (7.0%) women and 90 (4.2%) men. The adjusted hazard ratio (95% CI) for fracture in subjects with high (Ն15 M) compared with low levels (<9.0 M) of tHcy was 2.42 (1.43-4.09) among women and 1.37 (0.63-2.98) among men. Doseresponse analyses indicated a positive association between plasma tHcy and risk of fracture in both sexes and a negative association between plasma folate and risk of fracture among women only. Plasma vitamin B 12 level or MTHFR genotype was not significantly related to risk of fracture after adjustments for confounding factors. The association between tHcy and risk of hip fracture was only slightly weakened by adjustments for plasma levels of vitamin B 12 and folate. Conclusions: tHcy seems to be a predictor for hip fracture among elderly men and women. Folate was a predictor among women only, whereas vitamin B 12 and MTHFR genotype did not predict hip fracture. Our data corroborate the hypothesis that homocysteine may play a role in the pathogenesis of osteoporotic fractures.

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Local and national electronic databases in Norway demonstrate a varying degree of validity

Cited by 49 publications

References 30 publications

Bisphosphonate Use and the Risk of Subtrochanteric or Femoral Shaft Fractures in Older Women

Bisphosphonate Use and the Risk of Subtrochanteric or Femoral Shaft Fractures in Older Women

Incidence of hip fracture in the Republic of Ireland and future projections: a population-based study

Plasma Homocysteine, Folate, and Vitamin B12 and the Risk of Hip Fracture: The Hordaland Homocysteine Study

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