Two-phase flows of gas and liquid are increasingly paid much attention to space application due to excellent properties of heat and mass transfer, so it is very meaningful to develop studies on them in microgravity. In this paper, gas-phase distribution and turbulence characteristics of bubbly flow in normal gravity and microgravity were investigated in detail by using Euler-Lagrange two-way model. The liquidphase velocity field was solved by using direct numerical simulations (DNS) in Euler frame of reference, and the bubble motion was tracked by using Newtonian motion equations that took into account interphase interaction forces including drag force, shear lift force, wall lift force, virtual mass force and inertia force, etc. in Lagrange frame of reference. The coupling between gas-liquid phases was made with regarding interphase forces as a momentum source term in the momentum equation of the liquid phase. Under the normal gravity condition, a great number of bubbles accumulate near the walls under the influence of the shear lift force, and addition of bubbles reduces turbulence of the liquid phase. Different from the normal gravity condition, in microgravity, an overwhelming majority of bubbles migrate towards the centre of the channel driven by the pressure gradient force, and bubbles have little effect on the turbulence of the liquid phase.