Local anaesthetic toxicity: prevention or cure?

Wildsmith, J.A.W.

doi:10.1111/j.1365-2044.2006.04842_1.x

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Much has been made in correspondence of prevention being the key where this complication is concerned [9] and this is, of course, the case. One respondent to this survey claimed the need for lipid meant unsafe practice as toxic plasma concentrations should not be reached if bupivacaine is given slowly in small aliquots, but unfortunately there is always the potential for human error, and intravenous injection can occur despite negative test doses and negative aspiration.…”

Section: Discussionmentioning

confidence: 99%

Availability of lipid emulsion in obstetric anaesthesia in the UK: a national questionnaire survey

Williamson

Haines

2008

Anaesthesia

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SummaryThere is evidence that administration of lipid emulsion improves outcome in cardiovascular collapse secondary to local anaesthetic toxicity. We sent a questionnaire to the lead consultant anaesthetist in every consultant-led labour ward in the UK asking about local guidelines for treatment of cardiac arrest, and whether or nor lipid emulsion was available on the labour ward and included in the guideline. We received replies from 195 (86%) labour wards. One hundred and seven (55%) reported having a guideline for the treatment of cardiovascular collapse secondary to local anaesthetic toxicity. Of these guidelines, lipid emulsion was included in 78 (40%). Lipid emulsion was readily available on 95 labour wards (49%). Of the remaining units, there were plans to make lipid available in the near future in 46 (46%). Of the 95 labour wards where lipid emulsion was readily available, 80 (84%) had a recommended dose regimen for its administration. Around three-quarters of labour wards in the UK either have lipid emulsion available or plan to obtain it. This uptake should ideally be 100%.

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Section: Discussionmentioning

confidence: 99%

Availability of lipid emulsion in obstetric anaesthesia in the UK: a national questionnaire survey

Williamson

Haines

2008

Anaesthesia

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“…To the editor: Lipid emulsion is being used more and more to reverse local anesthetic-induced toxicity [1][2][3][4]. We report a case in which a lipid emulsion was injected into the patient after tracheal intubation but a second convulsion occurred.…”

Section: Failure Of Lipid Emulsion To Reverse Neurotoxicity After An mentioning

confidence: 99%

Failure of lipid emulsion to reverse neurotoxicity after an ultrasound-guided axillary block with ropivacaine and mepivacaine

Calenda

Dinescu

2009

J Anesth

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Some Other Pharmacologically Active Drugs

Woodward¹

2012

Toxicological Effects of Veterinary Medicinal Products in Humans

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Some drugs, which do not conveniently fall into other categories, are reviewed in this chapter. They include some opiates (etorphine, butorphanol, buprenorphine and fentanyl), some drugs used for euthanasia, neuroactive steroids and sedative agents, the phenothiazines, butyrophenone neuroleptic agents, clenbuterol, some non-steroidal inflammatory drugs, local anaesthetics, tropane alkaloids and the steroid hormones. Some of these compounds are highly toxic and they pose a risk to occupational safety e.g. etorphine. Others may offer risks to consumers of food of animal origin and particularly if they are subject to abuse or misuse e.g. clenbuterol. These drugs and their toxicities are discussed in this chapter along with reference to occupational and consumer safety.

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Local anaesthetic toxicity: prevention or cure?

Cited by 4 publications

References 8 publications

Availability of lipid emulsion in obstetric anaesthesia in the UK: a national questionnaire survey

Availability of lipid emulsion in obstetric anaesthesia in the UK: a national questionnaire survey

Failure of lipid emulsion to reverse neurotoxicity after an ultrasound-guided axillary block with ropivacaine and mepivacaine

Some Other Pharmacologically Active Drugs

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