Local anaesthesia for fibreoptic bronchoscopy.

Teale, C.; Muers, Martin F.; Pearson, S. Vere

doi:10.1136/thx.45.8.646

Cited by 1 publication

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cocaine may also be injected intratracheally for topical anaesthesia of the lower respiratory tract and appears to be as effective as lidocaine (Davidson et al 1990;Gomes et al 1990;Teale et al 1990). However, cocaine has not been shown to be clearly superior to lidocaine for intratracheal anaesthesia, and the doses recommended (100 to 300mg) have been occasionally associated with significant adverse effects.…”

Section: Clinical Usementioning

confidence: 99%

Clinical Use of Cocaine

Middleton

Kirkpatrick

1993

Drug Safety

View full text Add to dashboard Cite

Following the isolation of cocaine from the extract of coca leaves in the late 1700s by Albert Neiman, the local anaesthetic properties of the drug have been evaluated. The anaesthetic effect of cocaine is believed to be the result of reversible blockade of nervous impulse conduction by the prevention of sodium ion movement within the cell membrane. The many undesired effects, however, are the result of adrenergic stimulation by means of prevention of noradrenaline (norepinephrine) uptake. The clinical use of cocaine in the modern era is associated primarily with surgical procedures involving the manipulation of mucous membranes, particularly those of the upper respiratory tract. Recently, based on problems with the potential for illicit use and adverse effects, alternative regimens have been investigated. In some settings these have been superior to cocaine. Further studies comparing various anaesthetic regimens are warranted.

show abstract

Section: Clinical Usementioning

confidence: 99%