Local allergic rhinitis

Gómez, Francisca; Rondón, Carmen; Salas, María; Campo, Paloma

doi:10.1097/aci.0000000000000150

Cited by 32 publications

(10 citation statements)

References 43 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…81 In LAR patients, nasal symptoms, local sIgE production, and type 2 response-dominated inflammation in nasal mucosa can be induced during natural exposure to aeroallergens or by nasal provocation test (NPT). 82 …”

Section: Definition and Classificationmentioning

confidence: 99%

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Cheng

Chen

et al. 2018

Allergy Asthma Immunol Res

246

198

View full text Add to dashboard Cite

Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2–3 decades in developing countries including China, with the prevalence of AR varying widely in these countries. A survey of self-reported AR over a 6-year period in the general Chinese adult population reported that the standardized prevalence of adult AR increased from 11.1% in 2005 to 17.6% in 2011. An increasing number of original articles and imporclinical trials on the epidemiology, pathophysiologic mechanisms, diagnosis, management and comorbidities of AR in Chinese subjects have been published in international peer-reviewed journals over the past 2 decades, and substantially added to our understanding of this disease as a global problem. Although guidelines for the diagnosis and treatment of AR in Chinese subjects have also been published, they have not been translated into English and therefore not generally accessible for reference to non-Chinese speaking international medical communities. Moreover, methods for the diagnosis and treatment of AR in China have not been standardized entirely and some patients are still treated according to regional preferences. Thus, the present guidelines have been developed by the Chinese Society of Allergy to be accessible to both national and international medical communities involved in the management of AR patients. These guidelines have been prepared in line with existing international guidelines to provide evidence-based recommendations for the diagnosis and management of AR in China.

show abstract

Section: Definition and Classificationmentioning

confidence: 99%

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Cheng

Chen

et al. 2018

Allergy Asthma Immunol Res

246

198

View full text Add to dashboard Cite

show abstract

“…Some ongoing mechanical and clinical investigations in AR are focused on how the Th2 cytokine microenvironment could affect and process AR-related pathology [4, 5]. Recent studies have shown that type 2 macrophages (M2) can influence IL-4 secretion and the IgE class switch process in cedar pollen-sensitized AR mice [6, 7], which suggests that M2 macrophages might have a role in the initiation and development of AR.…”

Section: Introductionmentioning

confidence: 99%

MiR-202-5p Promotes M2 Polarization in Allergic Rhinitis by Targeting MATN2

Wang¹,

Liu²,

Song³

et al. 2018

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: The aim of this study was to investigate the effect of MiR-202-5p on macrophages involved in allergic rhinitis. Methods: Thirty allergic rhinitis patients and 10 healthy controls were recruited. Nasal lavage was utilized to collect mucosal tissues and mucus-derived macrophages. Flow cytometry was used to detect and sort type 2 macrophages, and qRT-PCR and Western blot were adopted to determine the expression of miR-202-5p and MATN2. Luciferase reporter assay and biotin-RNA pulldown were performed to testify the direct binding of miR-202-5p with MATN2. MATN2 was further overexpressed to test its effect on M2 polarization. Results: miR-202-5p, which can promote M2 polarization, was highly expressed in allergic rhinitis mucosal tissues and macrophages compared with the healthy controls. MATN2 could be directly targeted by miR-202-5p and can reverse miR-202-5p-mediated M2 phenotype polarization in allergic rhinitis. Conclusions: miR-202-5p could target MATN2 to induce M2 polarization involved in allergic rhinitis.

show abstract

“…They have also been used to investigate local nasal allergic responses (87), although there is a need for additional studies to evaluate the sensitivity and specificity of the test.…”

Section: Methodsmentioning

confidence: 99%

An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Sixth Jack Pepys Workshop on Asthma in the Workplace

Tarlo¹,

Malo²,

Blay³

et al. 2017

Annals ATS

View full text Add to dashboard Cite

The Sixth Jack Pepys Workshop on Asthma in the Workplace focused on six key themes regarding the recognition and assessment of work-related asthma and airway diseases: (1) cleaning agents and disinfectants (including in swimming pools) as irritants and sensitizers: how to evaluate types of bronchial reactions and reduce risks; (2) population-based studies of occupational obstructive diseases: use of databanks, advantages and pitfalls, what strategies to deal with biases and confounding?; (3) damp environments, dilapidated buildings, recycling processes, and molds, an increasing problem: mechanisms, how to assess causality and diagnosis; (4) diagnosis of occupational asthma and rhinitis: how useful are recombinant allergens (component-resolved diagnosis), metabolomics, and other new tests?; (5) how does exposure to gas, dust, and fumes enhance sensitization and asthma?; and (6) how to determine probability of occupational causality in chronic obstructive pulmonary disease: epidemiological and clinical, confirmation, and compensation aspects. A summary of the presentations and discussion is provided in this proceedings document. Increased knowledge has been gained in each topic over the past few years, but there remain aspects of controversy and uncertainty requiring further research.

show abstract

Local allergic rhinitis

Abstract: The possibility of a local occupational rhinitis should be considered in workers with a clear history of occupational rhinitis and negative immunological test, especially in the case of high molecular weight allergens.

Cited by 32 publications

References 43 publications

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

MiR-202-5p Promotes M2 Polarization in Allergic Rhinitis by Targeting MATN2

An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Sixth Jack Pepys Workshop on Asthma in the Workplace

Contact Info

Product

Resources

About