Local administration of p-coumaric acid decreases lipopolysaccharide-induced acute lung injury in mice: In vitro and in silico studies

Souza, Tácio Nertan Cartaxo de; Santos, Flávio Martins dos; Alves, Polyane R.; Ferro, Jaqueline dos Santos; Correia, A. C. C.; Melo, Tarcísio S.; Soares, Wagner Rodrigues de Assis; Andrade, Bruno Silva; Lagente, Vincent; Barreto, Emiliano

doi:10.1016/j.ejphar.2021.173929

Cited by 6 publications

(1 citation statement)

References 41 publications

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“…Many health benefits have been attributed to pCA, such as antiangiogenic effects, protection of lens epithelial cells, protective effects on ethanol-induced male reproductive toxicity, protection against diabetes-associated spontaneous destruction of periodontal tissue, anti-inflammatory effects in rheumatoid arthritis, ameliorating of ionizing radiation-induced intestinal injury, anti-inflammatory effects in acute lung injury, neuroprotection, and protection against high-fat diet-induced metabolic dysregulation [ 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ]. The main bioactivities of pCA have also been related to its antioxidant properties through the blocking of ROS accumulation, but there is still a need for more studies to elucidate the activity in other possible metabolic pathways.…”

Section: Hydroxycinnamic Acidsmentioning

confidence: 99%

Chitosan–Hydroxycinnamic Acids Conjugates: Emerging Biomaterials with Rising Applications in Biomedicine

Ojeda-Hernández

Canales-Aguirre²,

Matías‐Guiu

et al. 2022

IJMS

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Over the past thirty years, research has shown the huge potential of chitosan in biomedical applications such as drug delivery, tissue engineering and regeneration, cancer therapy, and antimicrobial treatments, among others. One of the major advantages of this interesting polysaccharide is its modifiability, which facilitates its use in tailor-made applications. In this way, the molecular structure of chitosan has been conjugated with multiple molecules to modify its mechanical, biological, or chemical properties. Here, we review the conjugation of chitosan with some bioactive molecules: hydroxycinnamic acids (HCAs); since these derivatives have been probed to enhance some of the biological effects of chitosan and to fine-tune its characteristics for its application in the biomedical field. First, the main characteristics of chitosan and HCAs are presented; then, the currently employed conjugation strategies between chitosan and HCAs are described; and, finally, the studied biomedical applications of these derivatives are discussed to present their limitations and advantages, which could lead to proximal therapeutic uses.

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