Local administration of DFO-loaded lipid particles improves recovery after end-to-end reconstruction of rat median nerve

Sinis, Nektarios; Scipio, Frederica Di; Schönle, P.W.; Werdin, Frank; Kraus, Armin; Koopmanns, Guido; Masanneck, Carmen; Hermanns, Susanne; Danker, Timm; Guenther, Elke; Haerle, Max; Schaller, Hans-Eberhard; Geuna, Stefano; Mueller, H.-W.

doi:10.3233/rnn-2009-0517

Cited by 4 publications

(1 citation statement)

References 51 publications

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“… Six weeks ? Sinis et al, 2009 [ 93 ] Administration of Deferoxamine Wistar 48 Nerve transection / / Weekly 4 weeks 12 weeks Sinis et al, 2011 [ 94 ] Hemostatic procedures during nerve reconstruction Wistar 36 Nerve transection / / Weekly 4 weeks 12 weeks Stößel et al, 2017 [ 22 ] Reflex-based grasping, skilled forelimb reaching and electrodiagnostic evaluation in comparison Lewis 16 Nerve transection 7 mm 7 mm Every 4 weeks 5 weeks 12 weeks Werdin et al, 2009 [ 30 ] Electrophysical testing Wistar 54 Nerve transection 20 mm 20 mm Weekly after 4 weeks postoperatively for 20 weeks Neurorrhaphy: 5 weeks Autograft: 12 weeks 16 weeks …”

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confidence: 99%

The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury

et al. 2022

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The rat median nerve model is a well-established and frequently used model for peripheral nerve injury and repair. The grasping test is the gold-standard to evaluate functional recovery in this model. However, no comprehensive review exists to summarize the course of functional recovery in regard to the lesion type. According to PRISMA-guidelines, research was performed, including the databases PubMed and Web of Science. Groups were: (1) crush injury, (2) transection with end-to-end or with (3) end-to-side coaptation and (4) isogenic or acellular allogenic grafting. Total and respective number, as well as rat strain, type of nerve defect, length of isogenic or acellular allogenic allografts, time at first signs of motor recovery (FSR) and maximal recovery grasping strength (MRGS), were evaluated. In total, 47 articles met the inclusion criteria. Group I showed earliest signs of motor recovery. Slow recovery was observable in group III and in graft length above 25 mm. Isografts recovered faster compared to other grafts. The onset and course of recovery is heavily dependent from the type of nerve injury. The grasping test should be used complementary in addition to other volitional and non-volitional tests. Repetitive examinations should be planned carefully to optimize assessment of valid and reliable data.

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