Local Action of Heparin on Xanthomas

Treatment of xanthelasma palpebrarum with intralesional heparin sodium: a pilot study

“…2 Heparin sodium as a management option for xanthomas was used for the first time in the 1950s by Cornbleet. 3 In fact, heparin was thought to incite the elaboration in plasma of agents capable of modifying lipoprotein particles, and its use on the skin proved to be efficient. The technique has been dropped for centuries, until its recent reintroduction for treating XP.…”

“…2 There are no well-defined criteria to include PTCL-NOS into a particular type of lymphoma. 3 It has no evidence of systemic involvement at the time of diagnosis and differs in prognosis and treatment from systemic lymphomas with similar histological features. 3 The diagnosis is often difficult in the absence of specific anatomic-clinical and phenotypic criteria.…”

“…3 It has no evidence of systemic involvement at the time of diagnosis and differs in prognosis and treatment from systemic lymphomas with similar histological features. 3 The diagnosis is often difficult in the absence of specific anatomic-clinical and phenotypic criteria. PTCL-NOS is thus a diagnosis of exclusion, integrating in the appropriate clinical context, the presence of histopathological features distinctive of lymphoma with an aberrant T-cell immunophenotype and a clonal T-cell receptor gene rearrangement.…”

Xanthomatosis

“…Heparin has been shown to act both locally and generally on this disease. Cornbleet (1955) has shown that if it is injected into a xanthoma it may cause it to regress and disappear. Lever and others (1954) have demonstrated that intravenous injections of heparin cause an increased speed of migration of beta lipoproteins in the electrophoretic pattern and Lever and others (1955) have also shown that, using the ultra‐centrifuge, there is a shift of the lipids from the higher flotation constants to the 1‐10 class.…”

Clinical and dermoscopic assessment of ablative carbon dioxide laser versus intradermal heparin sodium in xanthelasma

“…It enhances the activity of lipoprotein lipase which plays a key role in lipid metabolism by catalyzing the hydrolysis of triglycerides 8 . Therefore, Cornbleet 9 suggested it as a promising treatment option for xanthomas since 1955. However, this approach was neglected for several decades, and in the last decade, two former studies assessed the efficacy of intradermal injection of heparin sodium in the treatment of xanthelasma and reported successful results 10,11 …”