1955
DOI: 10.1001/archderm.1955.01540260030006
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Local Action of Heparin on Xanthomas

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1956
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Cited by 8 publications
(5 citation statements)
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“…2 Heparin sodium as a management option for xanthomas was used for the first time in the 1950s by Cornbleet. 3 In fact, heparin was thought to incite the elaboration in plasma of agents capable of modifying lipoprotein particles, and its use on the skin proved to be efficient. The technique has been dropped for centuries, until its recent reintroduction for treating XP.…”
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confidence: 99%
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“…2 Heparin sodium as a management option for xanthomas was used for the first time in the 1950s by Cornbleet. 3 In fact, heparin was thought to incite the elaboration in plasma of agents capable of modifying lipoprotein particles, and its use on the skin proved to be efficient. The technique has been dropped for centuries, until its recent reintroduction for treating XP.…”
mentioning
confidence: 99%
“…2 There are no well-defined criteria to include PTCL-NOS into a particular type of lymphoma. 3 It has no evidence of systemic involvement at the time of diagnosis and differs in prognosis and treatment from systemic lymphomas with similar histological features. 3 The diagnosis is often difficult in the absence of specific anatomic-clinical and phenotypic criteria.…”
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“…Heparin has been shown to act both locally and generally on this disease. Cornbleet (1955) has shown that if it is injected into a xanthoma it may cause it to regress and disappear. Lever and others (1954) have demonstrated that intravenous injections of heparin cause an increased speed of migration of beta lipoproteins in the electrophoretic pattern and Lever and others (1955) have also shown that, using the ultra‐centrifuge, there is a shift of the lipids from the higher flotation constants to the 1‐10 class.…”
Section: Associated With Hypercholesterolemiamentioning
confidence: 99%
“…It enhances the activity of lipoprotein lipase which plays a key role in lipid metabolism by catalyzing the hydrolysis of triglycerides 8 . Therefore, Cornbleet 9 suggested it as a promising treatment option for xanthomas since 1955. However, this approach was neglected for several decades, and in the last decade, two former studies assessed the efficacy of intradermal injection of heparin sodium in the treatment of xanthelasma and reported successful results 10,11 …”
Section: Introductionmentioning
confidence: 99%