Local acriflavine: A new therapy for rhinoscleroma

Shaer, Mostafa El; Rizk, Mohamed Abdo; Shawaf, I.; Ali, Mahmoud Abdelwahab; Hashash, M.

doi:10.1017/s0022215100091301

Cited by 20 publications

(8 citation statements)

References 9 publications

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“…Several topical antibiotics have been used in the treatment of the chronic debilitating disorder of rhinoscleroma with varying degrees of success. 47,48 Topical intranasal antimicrobials like aureomycin 49 and acriflavine 2% solution 50,51 have also been tried, with several authors reporting good results in their studies. After the initial success of systemic rifampicin in the treatment of rhinoscleroma, Gamea 52 treated 30 patients with rhinoscleroma with topical rifampicin in atrophic cases and rifampicin infiltration in granulomatous forms.…”

Section: Resultsmentioning

confidence: 99%

State of the Art Review: Current Status of Topical Nasal Antimicrobial Agents

Goh¹,

Goode²

2000

The Laryngoscope

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The nasal cavity and paranasal sinuses are probably one of the last frontiers in the head and neck region where the use of topical antimicrobial agents is not yet established. Although the anatomy of the nasal cavity and the paranasal sinuses can theoretically be exploited for the administration of antimicrobials in rhinosinusitis, very few studies have been conducted to test the feasibility of this mode of therapy. We review the anatomical and physiological factors that should be considered in the use of topical nasal antimicrobial agents and the current status of topical nasal antimicrobial usage, and we make recommendations for the administration of topical nasal antimicrobial agents.

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Section: Resultsmentioning

confidence: 99%

State of the Art Review: Current Status of Topical Nasal Antimicrobial Agents

Goh¹,

Goode²

2000

The Laryngoscope

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“…ACF also revealed that the local ACF solution appeared to be an effective and safe remedy for the patients with rhinoscleroma and to be active against aerobe bacteria in the oral cavity (Shaer et al 1981;Pitten and Kramer 1999). ACF and proflavine are being widely used as an antiinfective agent for fishes (Richards 1977), although these agents are currently used and approved for limited human use due to their potential adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic effect of acriflavine against clinical isolates of Acanthamoeba spp

Polat

Karakuş

2012

Parasitol Res

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Acanthamoeba keratitis (AK) is a potentially devastating and sight-threatening infection of the cornea caused by the ubiquitous free-living amoebae, Acanthamoeba species. Its eradication is difficult because the amoebas encyst, making it highly resistant to anti-amoebic drugs. Acriflavine neutral (ACF) has been used for treatment of microbial infections for humans and fishes. The aim of our study was to evaluate the time-dependent cytotoxicities of ACF against Acanthamoeba spp. Trophozoites and cysts of three different strains (strain PAT06 Acanthamoeba castellanii, strain 2HH Acanthamoeba hatchetti, and strain 11DS A. hatchetti) of Acanthamoeba spp. were tested. All strains had been isolated from patients suffering from a severe AK. The effects of the ACF with the concentrations ranging from 15 to 500 mg mL(-1) on the cytotoxicity of Acanthamoeba strains were examined. ACF showed a time- and dose-dependent amebicidal action on the trophozoites and cysts. Pat06 (A. castellanii) was the most resistant, while strain 11DS (A. hatchetti) was the most sensitive. As a result, ACF could be concluded as a new agent for the treatment of Acanthamoeba infections. On the other hand, it still needs to be further evaluated by in vivo test systems to confirm the efficiency of its biological effect.

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“…We in search of good local chemotherapeutic agent without any side effects and with maximal efficacy, found acriflavin, an antiseptic used by surgeons for urinary bladder wash prior to surgery. Shaer et al (1981) first used acriflavin and achieved good results…”

Section: Resultsmentioning

confidence: 99%