Local accumulation of titanium released from a titanium implant in the absence of wear

Abstract

Titanium and its alloys, like the majority of metallic implant materials, release passive metal dissolution products. This raises the issues of amount and fate, i.e. transport, storage, and/or excretion of these metal dissolution products. In this paper we document titanium levels in tissues local to a commercially pure titanium implant in the absence of wear; compare these values to control tissues; and determine the relative contribution of the local accumulation to total release. Titanium fiber felts were implanted into the tibia of rabbits for periods up to 1 year. Bone and muscle tissue samples near the implant were collected. Using electrothermal atomic absorption spectrophotometry the samples were analyzed for titanium content. Compared to controls, titanium levels in the bone near the implant were elevated at 1-, 4-, and 12-month postoperative time points. The 12-month time point had higher periprosthetic bone titanium levels than both the 1- and the 4-month implant groups. Titanium levels in muscle tissue near the felt also indicated release was occurring. The data support the hypothesis that metal species released from titanium implants in the absence of wear have a limited solubility. As a result, they tend to remain in an area local to the implant.

Bioactivity of NANOZR Induced by Alkali Treatment

“…Firstly, zirconia is more compatible with esthetic requirements since the dark color of titanium can show through the pinkish hue of the cervical gingiva, especially in patients with a thin gingival biotype [12]. In addition, high titanium concentrations in tissue have been reported in the vicinity of titanium oral implants and in regional lymph nodes, suggesting that titanium is a sensitinogen in some individuals [13]. Moreover, products of titanium particle corrosion may provoke host reactions [14] and are thus a potential health hazard.…”

Comparison of metal concentrations in rat tibia tissues with various metallic implants

“…has higher periprosthetic bone Ti concentrations than both the 1-and 4-month time points. The Ti concentrations in the muscle tissue near the felt at 1, 4 and 12 months are also 0.02870.005, 0.02770.002 and 0.03170.010 mg/g, respectively [20]. Three different types of plates, namely, Co-Cr and Ni-Cr alloys, and commercially pure Ti grade 1, were connected in vivo to the mandibular bone surface of monkeys.…”

Galvanic corrosion of titanium-based dental implant materials

“…So, simulation of long-term exposure of implants using various electrochemical techniques could be a help for prediction of in vivo behavior. Despite the high corrosion resistance of titanium and its alloys, in vivo experiments showed accumulation of titanium ions in tissue adjacent to implants [19,20].…”