LoC sensor array platform for real-time coagulation measurements

Çakmak, Onur; Kılınç, Necmettin; Ermek, Erhan; Mostafazadeh, Alí; Elbüken, Çağlar; Yaralioglu, G.G.; Ürey, Hakan

doi:10.1109/memsys.2014.6765643

Cited by 4 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sensor and cartridge fabrication was performed using a procedure as reported in our earlier studies. 21,23,24 Briefly the nickel cantilevers were fabricated by a simple one mask process utilizing sputter, photolithography, electrodeposition and wet etching steps. The fabricated nickel cantilevers were 200 μm long, 20 μm wide and 2 μm thick.…”

Section: Sensor and Cartridge Fabricationmentioning

confidence: 99%

A cartridge based sensor array platform for multiple coagulation measurements from plasma

et al. 2015

Self Cite

View full text Add to dashboard Cite

ARTICLE This journal is © The Royal Society of Chemistry 2013Lab Chip, 2014, 00, 1-3 | 1 and Prothrombin Time (PT)). The system has a reader unit and a disposable cartridge. The reader has no electrical connections to the cartridge. This enables simple and low-cost cartridge designs and avoids reliability problems associated with the electrical connections. The cartridge consists of microfluidic channels and MEMS microcantilevers placed in each channel. Microcantilevers are made of electro-plated nickel. They are actuated remotely using an external electro-coil and the read-out is also conducted remotely by a laser. The phase difference between the cantilever oscillation and the coil drive is monitored in real-time. During coagulation, the viscosity of the blood plasma increases resulting in a change in phase read-out. The proposed assay was tested with human and control plasma samples for PT and aPTT measurements. PT and aPTT measurements with using control plasmas are comparable with manufacturer's data sheet and commercial reference device. The measurement system has an overall 7.28 % and 6.33 % CV for PT and aPTT, respectively. For further implementation, the microfluidic channels of the cartridge are functionalized for PT and aPTT tests by drying specific reagents in each channel. Since the simultaneous PT and aPTT measurements are needed in order to properly evaluate the coagulation system, one of the most prominent features of the proposed assay is the enabling parallel measurement of different coagulation parameters. Additionally, the design of the cartridge and the read out system, the obtained reproducible results with 10 µl plasma samples suggesting an opportunity of a possible Point-of -Care application.

show abstract

Section: Sensor and Cartridge Fabricationmentioning

confidence: 99%

A cartridge based sensor array platform for multiple coagulation measurements from plasma

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…The cantilever utilized in this study is fabricated utilizing an easy, single mask process utilising many stages [24][25][26]. Using Ansys code of the research presents the design, simulation as shown in Figure 4(a&b) shows the coil between two magnets in 3D.…”

Section: Results and Simulationsmentioning

confidence: 99%

Evaluation and calculations of modes resonant cantilever for laser optical fiber assembly

Ali

2020

IJEECS

View full text Add to dashboard Cite

Biosensors depend on cantilevers have developed a promising tool for detecting biomedical, optical laser communication and many fields of interactions with high accuracy. We modeled the operation of cantilevers with two magnetic and coil using Ansys program. This simulation technique can capably be used to select the appropriate design and dimensions of cantilever with the geometry of system. The primary main of the magnetic design is to improve the geometry of the coil and shape to yield a highly uniform for 3D of optical fiber includes Silica Glass and Nickel cantilever, two magnets and coil that apply to force on the cantilever cylinder is using as a cantilever in the designing of this case. Results from many assessments which usage micro-cantilever have made known that these biosensors can demonstrate good compassion and high resolve. Additionally, for smart materials will regulator the strategy in the associations of reducing the vibrations amplitude and frequency to development the effectiveness of the designer in the new uses. Purposes to this problem comprise modification the approaches of numbers the resonant frequency to yield by cantilivier after the signal pass from laser system. The experimental of mode resonant frequency (f n ) of 3933.1594 Hz illustrations reasonable agreement with the Comsol model being within 10% of the expected result.

show abstract

Optical fiber array based simultaneous parallel monitoring of resonant cantilever sensors in liquid

Mostafazadeh

Yaralioglu

Ürey

2016

Sensors and Actuators A: Physical

View full text Add to dashboard Cite

LoC sensor array platform for real-time coagulation measurements

Cited by 4 publications

References 6 publications

A cartridge based sensor array platform for multiple coagulation measurements from plasma

A cartridge based sensor array platform for multiple coagulation measurements from plasma

Evaluation and calculations of modes resonant cantilever for laser optical fiber assembly

Optical fiber array based simultaneous parallel monitoring of resonant cantilever sensors in liquid

Contact Info

Product

Resources

About