Lobularia maritima (L.) Desv. Aerial Parts Methanolic Extract: In Vitro Screening of Biological Activity

Marrelli, Mariangela; Argentieri, Maria Pia; Avato, Pinarosa; Conforti, Filomena

doi:10.3390/plants9010089

Cited by 14 publications

(15 citation statements)

References 48 publications

(67 reference statements)

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“…Our findings suggest that the roots have higher antioxidant potential than the aerial parts of the studied plant. Our results are much higher than those reported in a previous study that investigated the radical scavenging potency of Lobularia maritima methanol extracts from Tunisia with IC50 values equal to 253.81 ± 1.01 μg/mL and 937.70 ± 8.07 μg/mL, for the EtOAc fraction and the raw extract, respectively [33].…”

Section: Discussioncontrasting

confidence: 81%

Investigation of the Chemical Composition and Antioxidant and Antimicrobial Activities of Lobularia maritima: Potent Therapeutic Applications

Kouidhi

Zidi

Abdelwahed

et al. 2021

Journal of Chemistry

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Lobularia maritima, commonly known as sweet alyssum, is an annual ornamental halophyte widely spread along the Tunisian seashore. However, little is known about the phytochemical, antioxidant, and antimicrobial activities of Lobularia maritima. The present study aimed to investigate the potential biological properties of different parts (flowers, leaves, roots, and stems) of Tunisian L. maritima using diverse extraction methods. Extracts were then studied for their antioxidant properties, and the highest antioxidant activity was presented in the roots’ fractions. Added to this, flower, leaf, and root fractions showed interesting antimicrobial and antifungal activities against different Gram+ and Gram− bacteria and against Aspergillus ochraceus. Finally, the most active fractions (presenting the highest biological activities) were analyzed using silica gel purification and mass spectrometry coupled to gas chromatography (GC-MS) analysis, and different compounds were identified such as camphor, amide of oleic acids, tributyl acetylcitrate, betulinaldehyde, menthol, 1′-(butyn-3-one-1-yl)-, (1S, 2S, 5R), benzyl benzoate, 7-acetyl-6-ethyl-1,1,4,4-tetramethyltetralin, 2,4-heptadienal, (E,E), and nootkaton-11,12-epoxide. This work represents the first in-depth investigation of the content of bioactive compounds from Lobularia maritima. This species could potentially be a promising source of useful compounds for therapeutic applications.

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Section: Discussioncontrasting

confidence: 81%

Investigation of the Chemical Composition and Antioxidant and Antimicrobial Activities of Lobularia maritima: Potent Therapeutic Applications

Kouidhi

Zidi

Abdelwahed

et al. 2021

Journal of Chemistry

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“…Available studies related to the bioactivity of this plant were mostly focused on plant extracts, rather than essential oils. Marelli et al [ 10 ] reported several important health benefits of the extracts of aerial Lobularia maritima (L.) Desv. parts.…”

Section: Introductionmentioning

confidence: 99%

The Essential Oil of Tunisian Halophyte Lobularia maritima: A Natural Food Preservative Agent of Ground Beef Meat

Akacha

Švarc‐Gajić

Elhadef

et al. 2022

Life

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This study was directed towards the investigation of the chemical composition and antimicrobial properties of the essential oil of Tunisian halophyte Lobularia maritime (LmEO). The antibacterial effects against major food-borne pathogenic and food spoilage bacteria were tested using the well diffusion method, followed by the determination of the minimum inhibitory (MIC) and bactericidal (MBC) concentrations. The essential oil has shown strong antimicrobial activity against eight pathogenic strains, which was attributed mostly to predominant constituents of the essential oil: benzyl alcohol, linalool, terpien-4-ol and globulol, as well as to synergistic effects of its major and minor constituents. Considering strong antimicrobial effects of the tested essential oil, it was further tested as a natural alternative to food preservatives, using minced beef meat as a model system. Minced beef meat was spiked with 0.019, 0.038, and 0.076% of the essential oil and stored during 14 days at 4 °C, monitoring its microbiological, physicochemical, and sensory properties. Chemical analyses revealed that meat treated with 0.076% of LmEO at underwent a significant decrease (p < 0.05) in primary and secondary lipid oxidation and reduced metmyoglobin accumulation compared with control samples. Furthermore, microflora proliferation in the meat model system spiked with 0.076% of LmEO was significantly (p < 0.05) reduced in comparison to control. In addition, two multivariate exploratory techniques, namely principal component analysis (PCA) and hierarchical analysis (HCA), were applied to the obtained data sets to describe the relationship between the main characteristics of the meat samples with and without essential oil addition. The chemometric approach highlighted the relationships between meat quality parameters. Overall, results indicated that the essential oil of Lobularia maritima deserves to be considered as a natural preservative in the meat industry.

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“…Phytochemical screening indicates that L. maritima contains substances with high therapeutic value, such as fatty acids (capric, 9-oxononanoic, lauric, 14-methylpentadecanoic, palmitic, myristic, stearic, 16-methyloctadecanoic acid), terpenoids (dihydroactinidiolide, neophytadiene, betulinaldehyde, β -amyrin acetate, (+)-2-bornanone, and nootkaton-11,12-epoxide), and phytosterols ( β -sitosterol, 24-methylenecycloartanol, and tremulone) [ 118 , 119 , 120 ]. In addition, many compounds accumulated by L. maritima function as antioxidants, eliminating reactive oxygen species, but are also responsible for the antibacterial, anti-inflammatory, anticancer, antiobesity, and hepatoprotective properties of the raw plants [ 86 , 118 , 119 ]. This group includes flavonoids, anthocyanins, phenolic acids, and tannins, as well as essential oil compounds and macromolecules such as proteins and polysaccharides [ 119 , 120 , 121 , 122 ].…”

Section: Phytochemical Composition Of Halophytesmentioning

confidence: 99%

“…In addition, many compounds accumulated by L. maritima function as antioxidants, eliminating reactive oxygen species, but are also responsible for the antibacterial, anti-inflammatory, anticancer, antiobesity, and hepatoprotective properties of the raw plants [ 86 , 118 , 119 ]. This group includes flavonoids, anthocyanins, phenolic acids, and tannins, as well as essential oil compounds and macromolecules such as proteins and polysaccharides [ 119 , 120 , 121 , 122 ].…”

Section: Phytochemical Composition Of Halophytesmentioning

confidence: 99%

Evaluation of Halophyte Biopotential as an Unused Natural Resource: The Case of Lobularia maritima

et al. 2022

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Halophytes are plant species widely distributed in saline habitats, such as beaches, postindustrial wastelands, irrigated lands, salt flats, and others. Excessive salt level, known to limit plant growth, is not harmful to halophytes, which have developed a variety of defense mechanisms allowing them to colonize harsh environments. Plants under stress are known to respond with several morpho-anatomical adaptations, but also to enhance the production of secondary metabolites to better cope with difficult conditions. Owing to these adaptations, halophytes are an interesting group of undemanding plants with a high potential for application in the food and pharmaceutical industries. Therefore, this review aims to present the characteristics of halophytes, describe changes in their gene expression, and discuss their synthesized metabolites of pharmacognostic and pharmacological significance. Lobularia maritima is characterized as a widely spread halophyte that has been shown to exhibit various pharmacological properties in vitro and in vivo. It is concluded that halophytes may become important sources of natural products for the treatment of various ailments and for supplementing the human diet with necessary non-nutrients and minerals. However, extensive studies are needed to deepen the knowledge of their biological potential in vivo, so that they can be introduced to the pharmaceutical and food industries.

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Lobularia maritima (L.) Desv. Aerial Parts Methanolic Extract: In Vitro Screening of Biological Activity

Cited by 14 publications

References 48 publications

Investigation of the Chemical Composition and Antioxidant and Antimicrobial Activities of Lobularia maritima: Potent Therapeutic Applications

Investigation of the Chemical Composition and Antioxidant and Antimicrobial Activities of Lobularia maritima: Potent Therapeutic Applications

The Essential Oil of Tunisian Halophyte Lobularia maritima: A Natural Food Preservative Agent of Ground Beef Meat

Evaluation of Halophyte Biopotential as an Unused Natural Resource: The Case of Lobularia maritima

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