Lobularia libyca: Phytochemical Profiling, Antioxidant and Antimicrobial Activity Using In Vitro and In Silico Studies

Abstract

Lobularia libyca (L. libyca) is a traditional plant that is popular for its richness in phenolic compounds and flavonoids. The aim of this study was to comprehensively investigate the phytochemical profile by liquid chromatography, electrospray ionization and tandem mass spectrometry (LC-ESI-MS), the mineral contents and the biological properties of L. libyca methanol extract. L. libyca contains significant amounts of phenolic compounds and flavonoids. Thirteen compounds classified as flavonoids were identified. L. libyca is rich in nutrients such as Na, Fe and Ca. Moreover, the methanol extract of L. libyca showed significant antioxidant activity without cytotoxic activity on HCT116 cells (human colon cancer cell line) and HepG2 cells (human hepatoma), showing an inhibition zone of 13 mm in diameter. In silico studies showed that decanoic acid ethyl ester exhibited the best fit in β-lactamase and DNA gyrase active sites; meanwhile, oleic acid showed the best fit in reductase binding sites. Thus, it can be concluded that L. libyca can serve as a beneficial nutraceutical agent, owing to its significant antioxidant and antibacterial potential and due to its richness in iron, calcium and potassium, which are essential for maintaining a healthy lifestyle.

Enhancement of the Antioxidant Effect of Natural Products on the Proliferation of Caco-2 Cells Produced by Fish Protein Hydrolysates and Collagen

“…Due to the fact that consumers are interested in the mineral content of fish products, the essential minerals Mg, P, Ca, Fe, Zn and Se were determined. These elements are also potent antioxidants in different cell lines [ 30 , 31 , 32 , 33 , 34 ]. No data about the detection of minerals in the bioaccessible fractions of fish hydrolyzates have been studied yet; however, some authors have evaluated the content of minerals in fish extracts.…”

Desert Endemic Plants in Algeria: A Review on Traditional Uses, Phytochemistry, Polyphenolic Compounds and Pharmacological Activities

“…Numerous of the plants included here show very potential therapeutic properties, suggesting that more clinical research should be completed on them. However, only a few of them have compelling scientific and clinical support [ 97 , 98 , 99 ]. Considerable work should be put into finding and describing the bioactive components present in these plants, given the state of scientific understanding [ 100 ].…”

Quantitative comparison and evaluation between aerial and underground parts of Gentiana straminea through simultaneous determination of five major compounds by RP-HPLC

“…This medicine contains several bitter compounds, mainly secoiridoids and flavonoids, which are regarded as the major active components [ [5] , [6] , [7] , [8] ]. Flavonoids have been reported to have antioxidant activity and antimicrobial potential [ [9] , [10] , [11] ], while its ethanol extract produces an inhibitory effect on anthrax bacillus, staphylococci, typhoid bacillus, pneumococci, bacillus dysenteriae, and vibrio [ 12 , 13 ]. Historically, Chinese physicians prepared this medicine using the root of G. straminea , while Tibetan doctors typically used the entire plant.…”