Lobozoanthamine, a new zoanthamine-type alkaloid from the Indonesian soft coral Lobophytum sp.

Fattorusso, Ernesto; Romano, Adriana; Taglialatela‐Scafati, Orazio; Achmad, Mahmud; Bavestrello, Giorgio; Cerrano, Carlo

doi:10.1016/j.tetlet.2008.02.028

Cited by 29 publications

(13 citation statements)

References 18 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous chemical investigation on Lobophytum species resulted in the identification of various cembranoid diterpenes and several steroids, glycolipids, and alkaloids; some of which showed cytotoxic and anti-inflammatory activities (Uchio et al, 1981;Chang et al, 2000;Radhika et al, 2004;Muralidhar et al, 2005;Chao et al, 2007;Fattorusso et al, 2008;Cheng et al, 2009). In continuation of our search for bioactive products from Vietnamese marine organisms (Dang et al, 2007;Minh et al, 2007aMinh et al, , 2007bMinh et al, , 2008Tung et al, 2009), the present study on the soft coral Lobophytum sp.…”

Section: Introductionmentioning

confidence: 54%

Chemical components from the Vietnamese soft coral Lobophytum sp.

et al. 2010

View full text Add to dashboard Cite

Chromatographic separation resulted in the identification of one new squalene derivative, named lobophytene (1), three cembranoid diterpenes (2-4), and two sterols (5 and 6) from the Vietnamese marine soft coral Lobophytum sp. Their structures were identified on the basis of extensive spectroscopic data and comparison of those with reported data. Compounds 1 and 2 showed significant cytotoxic activities against lung (A549) and colon (HT-29) cell lines with IC(50) values of 8.2 and 5.6 microM for 1; 5.1 and 1.8 microM for 2, respectively.

show abstract

Section: Introductionmentioning

confidence: 54%

Chemical components from the Vietnamese soft coral Lobophytum sp.

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The first member of the zoanthamine-type alkaloid was isolated from Zoanthus sp. [69,70], followed by a series of analogs isolated from the genus Zoanthus , with the single exception of zooxanthellamine, which was isolated from the unicellular dinoflagellate Symbiodinium sp. [71].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Alcyonacea: A Potential Source for Production of Nitrogen-Containing Metabolites

et al. 2019

View full text Add to dashboard Cite

Alcyonacea (soft corals and gorgonia) are well known for their production of a wide array of unprecedented architecture of bioactive metabolites. This diversity of compounds reported from Alcyonacea confirms its productivity as a source of drug leads and, consequently, indicates requirement of further chemo-biological investigation. This review can be considered a roadmap to investigate the Alcyonacea, particularly those produce nitrogen-containing metabolites. It covers the era from the beginning of marine nitrogen-containing terpenoids isolation from Alcyonacea up to December 2018. One hundred twenty-one compounds with nitrogenous moiety are published from fifteen genera. Their prominent biological activity is evident in their antiproliferative effect, which makes them interesting as potential leads for antitumor agents. For instance, eleutherobin and sarcodictyins are in preclinical or clinical stages.

show abstract

“…Soft corals belonging to the genus Lobophytum (class Coelenterata, subclass Octocorallia, and family Alcyonaceae) are a source of macrocycliccembrane-type diterpenes and their cyclised derivatives, germacrenediterpene, steroids (Cheng et al 2008;Lu et al 2010;Hegazy et al 2011;Minh et al 2011;Govindam et al 2012) and zoanthamine-type alkaloids (Fattorusso et al 2008). Some of these metabolites have been shown to exhibit significant cytotoxic activity against the growth of various cancer cell lines (Cheng et al 2008Hegazy et al 2011;Quang et al 2011) as well as anti-inflammatory (Chao et al 2008;Lin et al 2009;Lin et al 2009;Lu et al 2010;Quang et al 2011) and/or antioxidant activity report on chemical constituents of the species Lobophytum lobophytum which has not been previously chemically characterised.…”

Section: Introductionmentioning

confidence: 99%