Lobocrasol, a New Diterpenoid from the Soft Coral Lobophytum crassum

Abstract

Lobocrasol (1), possessing an unprecedented diterpenoid skeleton, was isolated from the soft coral Lobophytum crassum. The structure of lobocrasol was established by extensive analysis of spectroscopic data.

Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum

“…Soft corals belonging to the genus Lobophytum (Alcyoniidae) have been well recognized as a rich source of secondary metabolites endowed with a range of structural diversity and various biological activities [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21]. Previous bioassay results of some cembraniods and their analogues have demonstrated remarkable pharmacological potential such as in vitro cytotoxicity against various cancer cell lines [2,3,4,5,6,7,8,9], anti-inflammatory properties [10,11,12], antimicrobial activities [10], and HIV-inhibitory activity [13].…”

“…Previous bioassay results of some cembraniods and their analogues have demonstrated remarkable pharmacological potential such as in vitro cytotoxicity against various cancer cell lines [2,3,4,5,6,7,8,9], anti-inflammatory properties [10,11,12], antimicrobial activities [10], and HIV-inhibitory activity [13]. In view of their scientific significance and potential usage, we have investigated the Dongsha Atoll soft coral Lobophytum crassum (Von Marenzeller, 1886) (Figure 1) for the bioactive substances.…”

Anti-Inflammatory Cembranoids from the Soft Coral Lobophytum crassum

“…Further investigation of this genus revealed more than 250 compounds categorized into cembrane-type diterpenoids [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58], other types of diterpenoids [59,60,61,62,63,64,65], lipids […”

“…This class of compounds possesses a three-methyl substituted 14-memberd ring system with an isopropyl unit, whereas this isopropyl moiety can be replaced with several types of side rings including a γ -lactone or an unsaturated five-membered ring, a δ -lactone or an unsaturated six-membered ring, and an ɛ -lactone or an unsaturated seven-membered ring (Figure 1). Moreover, the structural changes such as epoxidation, allylic, and isopropyl oxidation or cyclization can be found in almost all unsaturated parts of the ring system [5,8,11]. …”

A new steroid from the Red Sea soft coralLobophytum lobophytum

“…Some of these metabolites have been shown to exhibit significant cytotoxic activity against the growth of various cancer cell lines (Cheng et al 2008Hegazy et al 2011;Quang et al 2011) as well as anti-inflammatory (Chao et al 2008;Lin et al 2009;Lin et al 2009;Lu et al 2010;Quang et al 2011) and/or antioxidant activity report on chemical constituents of the species Lobophytum lobophytum which has not been previously chemically characterised.…”