Lobectomy in cystic fibrosis

Bragonier, R.; Grier, D.; Carswell, F.; Cunningham, Steve

doi:10.1016/s0954-6111(98)90521-2

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…[2][3][4][5][6][7][8][9][10][11] Our literature search did not find studies assessing survival time in a group of patients who had undergone partial lung resection and followed a period up to 16 years. Therefore, we reviewed the medical charts of our institutions aiming to assess the survival time after lobectomy and/or segmentectomy in 21 CF subjects.…”

Section: Introductionmentioning

confidence: 99%

Lung resection in cystic fibrosis: A survival analysis

Camargos

Bourgeois

Révillon

et al. 2007

Pediatric Pulmonology

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Summary. Lung resection may be considered for cystic fibrosis (CF) patients showing localized severe chronic atelectasis and/or bronchiectasis. Nonetheless, literature on survival after surgery is scarce. This study was carried out to assess survival time after partial lung resection. Twenty-one CF patients were operated from 1988 to 2003 and were followed until November 30th, 2004. Survival analysis was performed through Kaplan-Meier method. Mean age at resection was 8.09 years (SD 4.40 years) and two-thirds were females. Z-scores for height, weight, and body mass index as well as FEV 1 values showed no statistical significance when comparing values obtained from 2 years before to 2 years after resection. Eleven years after resection, survival probability was 93.8%. Our results suggest that lobectomy or segmentectomy are safe procedures and should be considered in carefully selected patients with unilateral severe symptomatic localized and chronic persistent atelectasis and/or bronchiectasis refractory to conservative management.

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Section: Introductionmentioning

confidence: 99%

Lung resection in cystic fibrosis: A survival analysis

Camargos

Bourgeois

Révillon

et al. 2007

Pediatric Pulmonology

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“…75 For CF patients with preoperative FEV 1 < 30%, response to lobectomy is reportedly very poor, but patients with less severe lung disease occasionally demonstrate improvement in pulmonary function and clinical status. 76,77 However, CF patients with NTM disease typically have diffuse pulmonary involvement, and lobectomy appears to have a very limited role.…”

Section: Surgicalmentioning

confidence: 99%

Nontuberculous Mycobacteria in Cystic Fibrosis

Nick

2003

Seminars in Respiratory and Critical Care Medicine

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Background-The clinical significance of the presence of non-tuberculous mycobacteria in the sputum of patients with cystic fibrosis is unclear. A retrospective case-control study was performed to assess possible risk factors for nontuberculous mycobacteria and its impact on clinical status in patients with cystic fibrosis. Methods-The records of all patients attending the Leeds cystic fibrosis clinics who were positive for non-tuberculous mycobacteria were examined. Each case was matched with two controls for sex, age, and respiratory function at the time of the first non-tuberculous mycobacteria isolate. Details of respiratory function, nutritional status, antibiotic and corticosteroid therapy, Shwachman-Kulczycki (S-K) score, Northern chest radiographic score, and the frequency of isolation of other bacteria and fungi were collected from two years before to two years after the first non-tuberculous mycobacteria isolate. The patients' genotype and the presence of diabetes mellitus were also recorded. Results-Non-tuberculous mycobacteria were isolated from 14 patients out of a cystic fibrosis population of 372 (prevalence = 3.8%). No significant eVect of nontuberculous mycobacteria was seen on respiratory function, nutritional status, or S-K score. There was a significant association with the number of intravenous antibiotic courses received before the first isolate with cases receiving, on average, twice as many courses as controls (cases 6.64, controls 2.86, 95% CI for diVerence 1.7 to 5.9). No significant diVerence was seen between cases and controls for Northern scores, previous steroid therapy, or the incidence of diabetes mellitus. Conclusions-Non-tuberculous mycobacteria infection in patients with cystic fibrosis is uncommon and its clinical impact appears to be minimal over a two year period. Frequent intravenous antibiotic usage is a possible risk factor for colonisation with non-tuberculous mycobacteria.

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Cystic fibrosis and the thoracic surgeon

Rolla

D’Andrilli

Rendina

et al. 2011

European Journal of Cardio-Thoracic Surgery

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Indications for thoracic surgery in patients with cystic fibrosis (CF) are principally represented by pleural diseases including pneumothorax, pleural effusion, and empyema and by parenchymal lung diseases including bronchiectasis, hemoptysis, and pulmonary abscess. Moreover, lung transplantation has proved a viable therapeutic option for progressive respiratory failure due to end-stage CF. Main surgical experiences in this setting are reviewed and discussed.

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Lobectomy in cystic fibrosis

Cited by 6 publications

References 5 publications

Lung resection in cystic fibrosis: A survival analysis

Lung resection in cystic fibrosis: A survival analysis

Nontuberculous Mycobacteria in Cystic Fibrosis

Cystic fibrosis and the thoracic surgeon

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