Lobectomía en Ratas: Modelo Quirúrgico Experimental. Resultados en La Densidad Alveolar

Abstract

Development of a rat model of lung lobectomyBackground: Surgical lung resection is required for multiple pulmonary diseases. After these procedures, the lung experiences a compensatory growth, which can be studied in animal models such as rats. Aim: To develop a surgical model of lung lobectomy in rats. Material and Methods: Forty seven rats of the strain Rattus norvegicus were used. Animals were anesthetized with atropine, ketamine and xylacine. The airway was managed with a facial mask to avoid intubation. An anesthetic evaluation protocol was followed and animals were oxygenated using a cephalic veil. Forty rats were subjected to a right lobectomy and seven animals were sham operated. Rats subjected to lobectomy were sacrificed at one, two, three and four weeks after operation. Results: All operated rats survived. There were significant differences in the number of alveolar intersections among rats subjected to lobectomy and sacrificed at three weeks compared to sham operated animals, with a lower number of alveoli among the former. Conclusions: We were able to develop the model of lobectomy, however we failed to demonstrate a compensatory growth among rats subjected to lobectomy. ResumenIntroducción: En la literatura está documentado que diferentes mamíferos tienen la capacidad de crecimiento compensatorio post resección pulmonar parcial. Objetivo: Crear un modelo quirúrgico de lobectomía en ratas, factible de desarrollar en nuestro medio, exponiendo algunas originalidades en relación a procedi-

Lobulación Pulmonar De La Rata Blanca (Rattus norvegicus albinus)

“…El conocer la lobulación pulmonar de la rata de laboratorio, resulta de utilidad para eventuales aplicaciones en las ciencias biomédicas, como lo es por ejemplo en la cirugía experimental resectiva pulmonar (Martínez et al, 2014). Dicho procedimiento quirúrgico, constituye el tratamiento de múltiples patologías benignas y malignas humanas, tanto en niños como en adultos, ya que se ha visto que el pulmón restablece su masa, estructura y función posterior a estas cirugías, lo que se denomina, crecimiento compensatorio.…”