Loading of Cefixime to pH sensitive chitosan based hydrogel and investigation of controlled release kinetics

Ata, Sadia; Rasool, Atta; Islam, Atif; Bibi, Ismat; Rizwan, Muhammad; Azeem, Muhammad; Qureshi, Anees ur Rehman; Iqbal, Munawar

doi:10.1016/j.ijbiomac.2019.11.091

Cited by 89 publications

(34 citation statements)

References 35 publications

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“…However, higher CS/CMC proportions in the complex CL:(CS:CMC) 40:(30:30) presented broad endothermic peaks of CMC and CL and a non-crystalline structure of CS owing to the formation of a polyelectrolyte complex in the dissolution medium [ 31 ]. Similar interpolymeric structures with CS have been previously observed [ 19 ].…”

Section: Resultssupporting

confidence: 87%

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Study of Different Chitosan/Sodium Carboxymethyl Cellulose Proportions in the Development of Polyelectrolyte Complexes for the Sustained Release of Clarithromycin from Matrix Tablets

et al. 2021

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This study investigated the combination of different proportions of cationic chitosan and anionic carboxymethyl cellulose (CMC) for the development of polyelectrolyte complexes to be used as a carrier in a sustained-release system. Analysis via scanning electron microscopy (SEM) Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) confirmed ionic interactions occur between the chitosan and carboxymethyl cellulose chains, which increases drug entrapment. The results of the dissolution study in acetate buffer (pH 4.2) showed significant increases in the kinetic profiles of clarithromycin for low proportions of chitosan/carboxymethyl cellulose tablets, while the tablets containing only chitosan had high relaxation of chitosan chains and disintegrated rapidly. The Korsmeyer–Peppas kinetic model for the different interpolymer complexes demonstrated that the clarithromycin transport mechanism was controlled by Fickian diffusion. These results suggest that the matrix tablets with different proportions of chitosan/carboxymethyl cellulose enhanced the ionic interaction and enabled the prolonged release of clarithromycin.

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Section: Resultssupporting

confidence: 87%

“…For the mathematical evaluations, we characterized drug release kinetics by fitting standard release to zero-order, Higuchi, and first-order models [ 19 , 20 ].

where

is the fractional drug released at time t (min) from the total amount released

.…”

Section: Methodsmentioning

confidence: 99%

Study of Different Chitosan/Sodium Carboxymethyl Cellulose Proportions in the Development of Polyelectrolyte Complexes for the Sustained Release of Clarithromycin from Matrix Tablets

et al. 2021

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“…However, when the sample was heated at 55°C, the anisotropic image appeared as a fan-like texture, indicating that the Hk phase was formed instead of the cubic phase, which was due to the transformation of the crystal structure (Fig. 5) [35] and also consistent with our previous research [26]. In addition, when the temperature drops to 20°C, the dark field of the image reappeared which indicated the formation of a cubic phase.…”

Section: Optimization Of Process Parameterssupporting

confidence: 89%

Topical gel based nanoparticles for the controlled release of oleanolic acid: design and in vivo characterization of a cubic liquid crystalline anti-inflammatory drug

Shi

Pan

Luo-lin

et al. 2021

BMC Complement Med Ther

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Background Oleanolic acid (OA) has multiple pharmaceutical applications including anti-inflammatory activity, but low permeability of the molecule limits its widespread use. Methods A cubic liquid crystalline nanoparticle (LCNP)-based gel was prepared as a potential topical delivery system for OA. The LCNP-based gel was optimized using rheological, drug release kinetic, and ex vivo permeation studies. Results The studies showed that the OA was trapped in the interior of the LCNP with a crystal form of Pn3m space. The optimized LCNP formulation performed well using in vitro release studies for up to 12 h (85.49 ± 0.21%). Ex vivo permeation studies showed that the LCNP-based gel formulation was superior to a standard gel formulation. The r2 value from the Peppas equation indicated good linearity, but showed irregular (non-Fickian) diffusion, suggesting that drug release was controlled by multiple processes. Conclusions In this study, OA-loaded LCNPs were prepared by the precursor method, resulting in a well-characterized OA-LCNP gel preparation. The gel was shown to be effective in a rodent carrageenan-induced hind paw inflammation model with sustained efficacy after a single application.

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“…They concluded on the tunable release profile of the active molecule using the pH of the release medium. pH‐dependent drug release using chitosan‐based polymeric materials was also shown by other authors 44,45 . As an innovative application, Ezati and Rhim 46 synthesized a chitosan‐based, pH‐dependent, color‐changing film.…”

Section: Natural Ph‐responsive Polymerssupporting

confidence: 52%

pH‐sensitive polymers: Classification and some fine potential applications

Ofridam

Tarhini

Lebaz

et al. 2021

Polymers for Advanced Techs

138

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Stimuli‐responsive materials in general and pH‐responsive polymers in particular have gained increasing interest during the last two decades. Their unique properties, which arise from their ability to exhibit sharp and reversible changes in response to environmental pH conditions, have made them suitable for various applications such as drug delivery and specific body‐site targeting, sensing and actuation, membrane functionalization, separation techniques, as well as in agriculture and food industry and even chemical industries. In the present review, the focus is on the general characteristics of pH‐responsive polymers in terms of their origin, chemical composition, and preparation. Moreover, some of the important and recent applications are reported and discussed.

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Loading of Cefixime to pH sensitive chitosan based hydrogel and investigation of controlled release kinetics

Cited by 89 publications

References 35 publications

Study of Different Chitosan/Sodium Carboxymethyl Cellulose Proportions in the Development of Polyelectrolyte Complexes for the Sustained Release of Clarithromycin from Matrix Tablets

Study of Different Chitosan/Sodium Carboxymethyl Cellulose Proportions in the Development of Polyelectrolyte Complexes for the Sustained Release of Clarithromycin from Matrix Tablets

Topical gel based nanoparticles for the controlled release of oleanolic acid: design and in vivo characterization of a cubic liquid crystalline anti-inflammatory drug

pH‐sensitive polymers: Classification and some fine potential applications

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