Abstract:Primary hypomagnesemia with secondary hypocalcemia (PHSH) is a genetically defined disease in which there is a malabsorption of magnesium from the intestine. The aim of this research was to encapsulate magnesium into autologous erythrocytes to be used in PHSH patients. A scheme to use a single syringe closed sterile system for the process is proposed. Controlled lysis of erythrocytes and the ability to reseal the loaded erythrocytes were investigated. Method: Suitable concentrations of salt solutions required … Show more
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