Loading hydrophilic drug in solid lipid media as nanoparticles: Statistical modeling of entrapment efficiency and particle size

Ghadiri, Maryam Khaleghi; Fatemi, Shohreh; Vatanara, Alireza; Doroud, Delaram; Najafabadi, Abdolhossein Rouholamini; Darabi, Maryam; Rahimi, Amir Abbas

doi:10.1016/j.ijpharm.2011.12.037

Cited by 126 publications

(74 citation statements)

References 21 publications

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“…The drug released from the PM-SLN nanoparticulate formulation gradually and lasted 24 h in the aqueous media. The average entrapment efficiency of the prepared formulations was reported to be 42-46% (30,32).…”

Section: Pm-sln Formulationmentioning

confidence: 99%

“…A modified high shear homogenization (HSH) microemulsion technique was used to prepare PM-SLN as previously described (30,32). Briefly, lipid (stearic acid) was heated to 85°C.…”

Section: Preparation Of Pm-slnmentioning

confidence: 99%

“…The properties of each PM-SLN formulation such as size, polydispersity index, % paromomycin loading, zeta potential, and entrapment efficiency were determined. The particle diameter of each sample was measured in triplicate by dynamic light scattering (Malvern, Nano-ZS, UK) as previously described (30,32).…”

Section: Preparation Of Pm-slnmentioning

confidence: 99%

“…The pharmaceutical applications of SLN have been evaluated in different studies (25)(26)(27)(28)(29). The preparation of PM-loaded SLNs (PM-SLN) has been described previously (30). In the present study, SLN is used as a PM delivery system (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Drug Targeting to Macrophages With Solid Lipid Nanoparticles Harboring Paromomycin: an In Vitro Evaluation Against L. major and L. tropica

et al. 2015

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Abstract. Leishmaniasis is a worldwide disease that leads to high mortality and morbidity in human populations. Today, leishmaniasis is managed via drug therapy. The drugs that are already in clinical use are limited to a number of toxic chemical compounds and their parasite drug resistance is increasing. It is therefore essential, in order to circumvent the current difficulties, to design a new anti-leishmanial drug treatment strategy. Besides producing new, active anti-leishmanial entities, another promising strategy could be developing novel delivery systems and formulations of the existing pharmaceutical ingredients to improve drug efficacy. In the present study, paromomycin sulfate (PM), as one of the promising antileishmanial drugs, was formulated in solid lipid nanoparticles (SLN), and its in vitro efficacy was investigated against different strains of Leishmania using a MTT test, Parasite-Rescue-Transformation-Assay, SYTO Green staining, and fluorescent microscope imaging. The results show that PM-loaded SLN is significantly more effective than PM in inhibiting parasite propagation (P<0.05) and that cytotoxicity of PM-SLN formulations is size dependent. According to our results, delivery of the drugs to the macrophages via nanoparticle utilization seems to be an accessible and practical approach.KEY WORDS: cutaneous leishmaniasis; drug delivery system; paromomycin sulfate; solid lipid nanoparticle.

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Section: Pm-sln Formulationmentioning

confidence: 99%

“…A modified high shear homogenization (HSH) microemulsion technique was used to prepare PM-SLN as previously described (30,32). Briefly, lipid (stearic acid) was heated to 85°C.…”

Section: Preparation Of Pm-slnmentioning

confidence: 99%

Section: Preparation Of Pm-slnmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Drug Targeting to Macrophages With Solid Lipid Nanoparticles Harboring Paromomycin: an In Vitro Evaluation Against L. major and L. tropica

et al. 2015

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“…EE and LC of nanoparticles were determined by analysing the concentration of free drug in dispersion medium (13,14). Nanoparticle dispersion was diluted with water at …”

Section: Entrapment Effi Ciency (Ee) and Loading Capacity (Lc) Of Nanmentioning

confidence: 99%

Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery

et al. 2015

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O and oleic acid were used as solid and liquid lipids. SLN, NLC and NE were found physically stable at various temperatures for 6 months. Case I diffusional drug release was detected as the dominant mechanism indicating Fickian drug diffusion from nanoparticles and nanoemulsion. The highest rate of drug penetration through rat skin was obtained with NE followed by NLC, SLN and a gel formulation. Nanoformulations significantly increased drug penetration through rat skin compared to the gel (p < 0.05). Thus, SLN, NLC and NE of LRX can be suggested for relieving painful and inflammatory conditions of the skin.

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Lipid Nanoparticles for Drug Delivery

Wang

Liu

et al. 2021

Advanced NanoBiomed Research

214

110

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Lipid nanoparticles have attracted significant interests in the last two decades, and have achieved tremendous clinical success since the first clinical approval of Doxil in 1995. At the same time, lipid nanoparticles have also demonstrated enormous potential in delivering nucleic acid drugs as evidenced by the approval of two RNA therapies and mRNA COVID‐19 vaccines. In this review, an overview on different classes of lipid nanoparticles, including liposomes, solid lipid nanoparticles, and nanostructured lipid carriers, is first provided, followed by the introduction of their preparation methods. Then the characterizations of lipid nanoparticles are briefly reviewed and their applications in encapsulating and delivering hydrophobic drugs, hydrophilic drugs, and RNAs are highlighted. Finally, various applications of lipid nanoparticles for overcoming different delivery challenges, including crossing the blood–brain barrier, targeted delivery, and various routes of administration, are summarized. Lipid nanoparticles as drug delivery systems offer many attractive benefits such as great biocompatibility, ease of preparation, feasibility of scale‐up, nontoxicity, and targeted delivery, while current challenges in drug delivery warrant future studies about structure–function correlations, large‐scale production, and targeted delivery to realize the full potential of lipid nanoparticles for wider clinical and pharmaceutical applications in future.

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Loading hydrophilic drug in solid lipid media as nanoparticles: Statistical modeling of entrapment efficiency and particle size

Cited by 126 publications

References 21 publications

Drug Targeting to Macrophages With Solid Lipid Nanoparticles Harboring Paromomycin: an In Vitro Evaluation Against L. major and L. tropica

Drug Targeting to Macrophages With Solid Lipid Nanoparticles Harboring Paromomycin: an In Vitro Evaluation Against L. major and L. tropica

Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery

Lipid Nanoparticles for Drug Delivery

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