lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population

Felipe, Aledson Vitor; Silva, Tiago D.; Pimenta, Célia Aparecida Marques; Kassab, P; Forones, Nora Manoukian

doi:10.4067/s0716-97602012000400007

Cited by 14 publications

(8 citation statements)

References 30 publications

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“…Among the SNPs of the IL-8 gene evaluated, IL-8-251 A/T is the one that is most commonly related to increased risk for and poor prognosis of several diseases, including gastric cancer [52][53][54]. However, our results did not show increased susceptibility to the gastric diseases evaluated for their ; and e and f IL-10-592 CC (wild-type) and CA+AA (polymorphic).…”

Section: Discussioncontrasting

confidence: 76%

Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer

et al. 2015

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Functional polymorphisms in promoter regions can produce changes in the affinity of transcription factors, thus altering the messenger ribonucleic acid (mRNA) expression levels of inflammatory cytokines associated with the risk of cancer development. The goal of this study was to evaluate the influence that polymorphisms in the cytokine genes known as TNF-α-308 G/A (rs1800629), TNF-α-857 C/T (rs1799724), IL-8-251 T/A (rs4073), IL-8-845 T/C (rs2227532), and IL-10-592 C/A (rs1800872) have on changes to mRNA expression levels and on the risks of chronic gastritis (CG) and gastric cancer (GC). A sample of 723 individuals was genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Relative mRNA expression levels were measured using quantitative real-time PCR (qPCR). Polymorphisms TNF-α-308 G/A and IL-8-251 A/T were not associated with risks of these gastric lesions. However, TNF-α-857 C/T, IL-8-845 T/C, and IL-10-592 C/A were found to be associated with a higher risk of GC, and IL-10-592 C/A was found to be associated with a higher risk of CG. The relative mRNA expression levels (RQ) of TNF-α, IL-8, and IL-10 were markedly downregulated in the CG group (median RQs = 0.128, 0.247, and 0.614, respectively), while the RQ levels of TNF-α in the GC group were upregulated (RQ = 2.749), but were basal for IL-8 (RQ = 1.053) and downregulated for IL-10 (RQ = 0.179). When the groups were stratified according to wild-type and polymorphic alleles, only for IL-8-845 T/C the polymorphic allele was found to influence the expression levels of this cytokine. IL-8-845 C allele carriers were significantly upregulated in both groups (GC and CG; RQ = 3.138 and 2.181, respectively) when compared to TT homozygotes (RQ = -0.407 and 0.165, respectively). In silico analysis in the IL-8 promoter region revealed that the presence of the variant C allele in position -845 is responsible for the presence of the binding sites for two transcription factors (REL and CREB1), which are involved in increased gene expression. Polymorphic alleles were not shown to have any effect on the expression levels of TNF-α and IL-10. Taken together, our findings provide evidence for an association of TNF-α-857 C/T, IL-8-845 T/C, and IL-10-592 C/A with a higher risk of gastric cancer and also demonstrate the influence that the polymorphic C allele of IL-8-845 has on changes to the gene expression levels of this cytokine.

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Section: Discussioncontrasting

confidence: 76%

Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer

et al. 2015

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“…71 Moreover, a Brazilian study found that individuals with A/A genotype may have protective effect for gastric cancer. 72 These contrasting results suggest that IL-8-251T/A SNP may be associated differently with gastric diseases depending on the ethnicity. pylori infection and suggested the occurrence of repeated transmission of H. pylori (same or different strain) between the individuals who live in the same household, due to a greater opportunity of personal contact.…”

Section: 7879contrasting

confidence: 38%

Genes de patogenicidade de Helicobacter pylori, polimorfismos de citocinas e fatores ambientais afetam o desenvolvimento de doenças gástricas: uma visão geral

Vianna¹,

Silva²,

Ramis³

2016

Rev Epidemiol Control Infect

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Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. pylori possui um conjunto de fatores de patogenicidade, tais como cagA, vacA, iceA, babA, para colonizar a mucosa gástrica e estabelecer infecção crônica. Estes fatores bacterianos são agentes essenciais em modular a resposta imune envolvida na iniciação da carcinogênesegástrica. Os fatores genéticos do hospedeiro contribuem para regular a resposta inflamatória e para o agravamento da lesão da mucosa gástrica uma vez que a infecção gástrica por H. pylori induz a produção de várias citocinas pró e anti-inflamatórias no hospedeiro. O papel prejudicial dos fatores ambientais está relacionado com as precárias condições socioeconômicas, com o consumo de sal, com o tabagismo e com o consumo de álcool. Conclusão: Ao decifrar as regras deterministas -se houver -dessa interação entre fatores da bactéria, do hospedeiro e variáveis ambientais, será possível prever, tratar e, finalmente, prevenir graves doenças gastroduodenais. Background and Objectives:Helicobacter pylori is a Gram-negative bacterium that colonizes the stomach of approximately 50% of the world´s human population. This microorganismis the major causal agent of gastritis and is an important risk factor for the development of peptic ulcer disease and gastric carcinoma. The factors that determine these diverse clinical outcomes are subject to continuous investigations and is thought to be determined by interaction of bacterial factors, host immune system and environmental variables. The aim of this review is to provide an overview of these factors that influence susceptibility to severe outcomes of H. pylori

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“…Mutations in the CYP1A1 , GSTM1 , MTHFR , SRD5A2 , AR , and GSTA1 genes were relevant in prostate cancer in Latin Americans [108,109,110,111,112], also determined in Caucasians and Asians [113,114,115,116,117,118,119,120,121]. The IL-1 , TP53 , WNT , 8q24 region and IL-8 genes were consistent with gastric cancer in Latin Americans [122,123,124,125,126], as well as in some Asians and Caucasians [127,128,129,130]. The CDKN2A and MC1R genes were related with myeloma in Latin Americans [131], as well as in Caucasians [132,133].…”

Section: Germline Cancer Predisposition In Latin Americamentioning

confidence: 98%

State of Art of Cancer Pharmacogenomics in Latin American Populations

López‐Cortés

Guerrero

Redal

et al. 2017

IJMS

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Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.

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lnterleukin-8 gene polymorphism and susceptibility to gastric cancer in a brazilian population

Cited by 14 publications

References 30 publications

Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer

Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer

Genes de patogenicidade de Helicobacter pylori, polimorfismos de citocinas e fatores ambientais afetam o desenvolvimento de doenças gástricas: uma visão geral

State of Art of Cancer Pharmacogenomics in Latin American Populations

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