lnterleukin-10 in the Brain

Strle, Klemen; Zhou, Jian; Shen, Wen Hong; Broussard, Suzanne R.; Johnson, Rodney W.; Freund, Gregory G.; Dantzer, Robert; Kelley, Keith W.

doi:10.1615/critrevimmunol.v21.i5.20

Cited by 341 publications

(215 citation statements)

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“…IL-10 suppresses the production and activity of pro-inflammatory cytokines at several levels, including transcription, translation, and release. 23 In our study, the increased in rhEPO3000 group (P = 0.011, 0.022, 0.017, and 0.046, respectively) and rhEPO5000 group (P \ 0.001). There was no significant difference with respect to the expressions of TNF-a, IL-1b, IL-6, and IL-10 between rhEPO1000 group and saline group (P = 0.118, 0.761, 0.934, and 0.779, respectively) Preemptive rhEPO and neuropathic pain 601 sustained increase in the expression of IL-10 suggested a compensatory response to the increases in the potential pro-inflammatory cytokines.…”

Section: Discussionsupporting

confidence: 45%

Effects of recombinant human erythropoietin on neuropathic pain and cerebral expressions of cytokines and nuclear factor-kappa B

Jia

Jin

et al. 2009

Can J Anesth/J Can Anesth

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Purpose The effect of recombinant human erythropoietin (rhEPO) on neuropathic pain remains unclear. This study aimed to determine the effects of preemptive administration of rhEPO on the behavioural changes and neuroinflammatory responses in a rat model of neuropathic pain. Methods Fifty rats were randomly allocated into five groups, sham-operation treated with saline and L5 spinal nerve transection treated with different doses of rhEPO (0 [saline], 1000, 3000, or 5000 U Á kg -1 , respectively). The rats were intraperitoneally treated from 1 day before surgery to post-surgery day 7. The mechanical (paw pressure thresholds, PPT) and thermal thresholds (paw withdrawal latencies, PWL) were measured on post-surgery days 1, 3, and 7. The contralateral brain was obtained on post-surgery day 7 to determine the expressions of tumour necrosis factor (TNF-a), interleukin (IL)-1b, IL-6, L-10, and nuclear factor-kappa B (NF-jB) activity. Results There were significant decreases in PPT and PWL after L5 spinal nerve transection (P \ 0

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Section: Discussionsupporting

confidence: 45%

Effects of recombinant human erythropoietin on neuropathic pain and cerebral expressions of cytokines and nuclear factor-kappa B

Jia

Jin

et al. 2009

Can J Anesth/J Can Anesth

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“…It was reported that IL-10 could suppress the neurotoxic functions of TNF-α and IFN-γ [21] and alleviate BBB damage. IL-10 is also conductive to the restoration of nerve cells and has a neuroprotective effect [22] .…”

Section: Discussionmentioning

confidence: 99%

Human umbilical cord blood mesenchymal stem cell transplantation suppresses inflammatory responses and neuronal apoptosis during early stage of focal cerebral ischemia in rabbits

et al. 2014

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Aim: Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) have been shown to ameliorate cerebral ischemia in animal models. In this study we investigated the effects of hUCB-MSCs on inflammatory responses and neuronal apoptosis during the early stage of focal cerebral ischemia in rabbits. Methods: Focal cerebral ischemia was induced in male New Zealand rabbits by occlusion of MCA for 2 h. The blood samples were collected at different time points prior and during MCAO-reperfusion. The animals were euthanized 3 d after MCAO, and the protein levels of IL-1β, IL-6, IL-10, and TNF-α in the serum and peri-ischemic brain tissues were detected using Western blot and ELISA, respectively. Inflammatory cell infiltration, neuronal apoptosis and neuronal density were measured morphologically. hUCB-MSCs (5×10 6 ) were iv injected a few minutes after MCAO. Results: The serum levels of IL-1β, IL-6, and TNF-α were rapidly increased, and peaked at 2 h after the start of MCAO. hUCB-MSC transplantation markedly and progressively suppressed the ischemia-induced increases of serum IL-1β, IL-6, and TNF-α levels within 6 h MCAO-reperfusion. Focal cerebral ischemia decreased the serum level of IL-10, which was prevented by hUCB-MSC transplantation. The expression of IL-1β, IL-6, IL-10, and TNF-α in the peri-ischemic brain tissues showed similar changes as in the serum. hUCB-MSC transplantation markedly suppressed the infiltration of inflammatory cells, and increased the neuronal density around the ischemic region. Furthermore, hUCB-MSC transplantation significantly decreased the percentage of apoptosis around the ischemic region. Conclusion: hUCB-MSCs transplantation suppresses inflammatory responses and neuronal apoptosis during the early stage focal cerebral ischemia in rabbits.

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“…[16][17][18] Strengthening the anti-inflammatory response within the CNS might therefore be an attractive therapeutic strategy to reduce the production and/or action of pro-inflammatory mediators and to diminish the related pathophysiological responses.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect by lentiviral-mediated overexpression of IL-10 or IL-1 receptor antagonist in rat glial cells and macrophages

et al. 2010

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lnterleukin-10 in the Brain

Cited by 341 publications

References 0 publications

Effects of recombinant human erythropoietin on neuropathic pain and cerebral expressions of cytokines and nuclear factor-kappa B

Effects of recombinant human erythropoietin on neuropathic pain and cerebral expressions of cytokines and nuclear factor-kappa B

Human umbilical cord blood mesenchymal stem cell transplantation suppresses inflammatory responses and neuronal apoptosis during early stage of focal cerebral ischemia in rabbits

Anti-inflammatory effect by lentiviral-mediated overexpression of IL-10 or IL-1 receptor antagonist in rat glial cells and macrophages

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