LncSHRG promotes hepatocellular carcinoma progression by activating <i>HES6</i>

Yang, Xu; Liang, Chaojie; Zhang, Dongxin; Li, Guanqun; Gao, Xia; Fu, Jiayao; Xia, Feng; Ji, Jiajun; Zhang, Lijun; Li, Guangming; Wu, Jixiang

doi:10.18632/oncotarget.19906

Cited by 33 publications

(19 citation statements)

References 43 publications

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“…A previous study reported that lncRNAs can exert biological functions via a variety of mechanisms, including transcriptional and post-transcriptional regulation. For example, lymphocyte-specific protein 1 pseudogene recruited DNA-binding protein SATB1 to initiate transcription of hes family bHLH transcription factor 6 and promote hepatocellular carcinoma progression ( 13 ). Additionally, lncRNA MALAT1 acted as a competing endogenous RNA of miR-144-3p to promote metastasis and proliferation in osteosarcoma cells ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA LINC01296 promotes tumor growth and progression by sponging miR-5095 in human cholangiocarcinoma

Zhang

Xie

et al. 2018

Int J Oncol

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The aim of the present study was to elucidate whether, and how, long intergenic non-protein coding RNA 1296 (LINC01296) is involved in the modulation of human cholangiocarcinoma (CCA) development and progression. Microarray data analysis and reverse transcription-quantitative polymerase chain reaction analysis demonstrated that LINC01296 was significantly upregulated in human CCA compared with nontumor tissues. Furthermore, the expression of LINC01296 in human CCA was positively associated with tumor severity and clinical stage. Knockdown of LINC01296 dramatically suppressed the viability, migration and invasion of RBE and CCLP1 cells, and promoted cell apoptosis in vitro. Furthermore, LINC01296 knockdown inhibited tumor growth in a xenograft model. Mechanistically, LINC01296 was demonstrated to sponge microRNA-5095 (miR-5095), which targets MYCN proto-oncogene bHLH transcription factor (MYCN) mRNA in human CCA. By inhibition of miR-5095, LINC01296 overexpression upregulated the expression of MYCN and promoted cell viability, migration and invasion in CCA cells. The results reveal that the axis of LINC01296/miR-5095/MYCN may be a mechanism to regulate CCA development and progression.

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Section: Discussionmentioning

confidence: 99%

Long noncoding RNA LINC01296 promotes tumor growth and progression by sponging miR-5095 in human cholangiocarcinoma

Zhang

Xie

et al. 2018

Int J Oncol

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“…Recently, Yang et al, identified HAND2-AS1 as a potential biomarker for HCC tumorigenesis and metastasis [ 75 ]. Similarly, high expression levels of CASC15 [ 175 ], CYTOR (also known as Linc00152 ) [ 174 ], HANR [ 176 ], ICR (ICAM-1-Related ncRNA) [ 177 ], linc-UFC1 [ 166 ], lncRNA-ATB [ 170 ], lncSHRG [ 178 ], MVIH [ 179 ], PANDAR [ 180 ], PCAT14 [ 181 ], SNHG6 [ 182 ], SNHG20 [ 183 ], TINCR [ 184 ], TMCC1-AS1 [ 72 ], UBE2CP3 [ 185 ], WRAP53 [ 116 ]], ZEB1-AS1 [ 186 ], as well as the downregulation of LOC728290 [ 187 ], GAS5 [ 188 ], DILC [ 189 ], or WT1-AS [ 190 ], have been variably shown to be correlated with clinical severity, aggressive pathological features, metastasis, and/or poor outcome in HCC patients ( Table S1 ). However, it should be noted that given that lncRNA is a fairly young research field, many of these associations have thus far been reported in single studies.…”

Section: Putative Diagnostic and Prognostic Lncrnas In Hccmentioning

confidence: 99%

The Role of Long Non-Coding RNAs in Hepatocarcinogenesis

Lanzafame

Bianco

Terracciano

et al. 2018

IJMS

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Whole-transcriptome analyses have revealed that a large proportion of the human genome is transcribed in non-protein-coding transcripts, designated as long non-coding RNAs (lncRNAs). Rather than being “transcriptional noise”, increasing evidence indicates that lncRNAs are key players in the regulation of many biological processes, including transcription, post-translational modification and inhibition and chromatin remodeling. Indeed, lncRNAs are widely dysregulated in human cancers, including hepatocellular carcinoma (HCC). Functional studies are beginning to provide insights into the role of oncogenic and tumor suppressive lncRNAs in the regulation of cell proliferation and motility, as well as oncogenic and metastatic potential in HCC. A better understanding of the molecular mechanisms and the complex network of interactions in which lncRNAs are involved could reveal novel diagnostic and prognostic biomarkers. Crucially, it may provide novel therapeutic opportunities to add to the currently limited number of therapeutic options for HCC patients. In this review, we summarize the current status of the field, with a focus on the best characterized dysregulated lncRNAs in HCC.

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“…Since the discovery of SATB1, its role in the pathogenesis of various cancers has been investigated. Importantly, upregulation of SATB1 has been shown to promote many pathological features across a wide range of cancers [38,39] including breast [1,[40][41][42], colorectal [2,[43][44][45], lung [46,47], nasopharyngeal [48], oesophageal [3,49,50], gastric [51,52], pancreatic [53,54], ovarian [32,55,56], liver [57][58][59], prostate [60][61][62][63], bladder [64,65], and brain [66][67][68][69][70]. In most cancers, the SATB1 expression is positively associated with increased tumour size, lymph node involvement and metastasis [71,72], tumour progression [1,2], poor prognosis [50,56] and reduced overall survival [49,54].…”

Section: Satb1 and Cancermentioning

confidence: 99%

Functional relevance of SATB1 in immune regulation and tumorigenesis

Sunkara

Gupta

Hansbro

et al. 2018

Biomedicine & Pharmacotherapy

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The Special AT-rich Sequence Binding Protein 1 (SATB1) is a chromatin organiser and transcription factor which regulates numerous cellular processes such as differentiation, proliferation and apoptosis through effects on gene expression. SATB1 undergoes various post-translational modifications, which determine its interaction with co-activators and co-repressors to induce regulation of gene transcription. SATB1 is an identified oncogene, its increased expression is associated with poor prognosis in many cancers. This paper provides a review on SATB1-mediated immune responses and on its target genes in the context of tumorigenesis and tumour progression. Specifically, we discuss the role of SATB1 in tumour immunity, Epithelial to Mesenchymal Transition (EMT), metastasis and multidrug resistance. Therapeutic targeting of aberrant SATB1 may be an important strategy in the treatment of cancer.

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LncSHRG promotes hepatocellular carcinoma progression by activating HES6

Cited by 33 publications

References 43 publications

Long noncoding RNA LINC01296 promotes tumor growth and progression by sponging miR-5095 in human cholangiocarcinoma

Long noncoding RNA LINC01296 promotes tumor growth and progression by sponging miR-5095 in human cholangiocarcinoma

The Role of Long Non-Coding RNAs in Hepatocarcinogenesis

Functional relevance of SATB1 in immune regulation and tumorigenesis

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