“…In recent years, the identification of reliable predictors of nCRT response in LARC has gained increasing attention in several fields, including gene, radiology, and pathology. Differential expression levels of genes, such as FOXK family members and lncRNA, showed biologically meaningful associations to nCRT response, 16,17 while this method is expensive for patients. In addition, as a significant tool to assess the tumor stage in LARC patients, 18 MRI was reported to predict nCRT response (AUC: 0.895).…”