LncRNAs regulate metabolism in cancer

Lin, Wenyu; Zhou, Qing; Wang, Chaoqun; Zhu, Liyuan; Bi, Chao; Zhang, Shuzhen; Wang, Xian; Jin, Hongchuan

doi:10.7150/ijbs.40769

Cited by 130 publications

(103 citation statements)

References 121 publications

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“…This aberrant metabolic function facilitates anabolic growth in the course of nutrient-depleted situations, catabolism to sustain cell survival for the period of nutrient insufficiency, and protection of redox homeostasis to neutralize the metabolic influences of oncogene activation, tumor suppressor deficiency or other cellular stresses ( 6 ). Such metabolic reprogramming involves several genes and molecular pathways among them are long non-coding RNAs (lncRNAs) ( 7 ). These transcripts comprise a large proportion of human transcriptome, have sizes larger than 200 nucleotides and share several features with mRNA coding genes; yet, they lack considerable open reading frames ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…These transcripts comprise a large proportion of human transcriptome, have sizes larger than 200 nucleotides and share several features with mRNA coding genes; yet, they lack considerable open reading frames ( 8 ). Not only can they regulate cell proliferation, cell death, migration, invasion and stemness properties ( 9 ), but also they have critical roles in the regulation of cancer metabolism ( 7 ). The latter has been supported by a bunch of evidence which reports aberrant expression of metabolism-related lncRNAs in cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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The Role of Long Non-coding RNAs in Cancer Metabolism: A Concise Review

2020

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Dysregulation of metabolic pathways in cancer cells is regarded as a hallmark of cancer. Identification of these abnormalities in cancer cells dates back to more than six decades, far before discovery of oncogenes and tumor suppressor genes. Based on the importance of these pathways, several researchers have aimed at modulation of these functions to intervene with the pathogenic course of cancer. Numerous genes have been shown to participate in the regulation of metabolic pathways, thus aberrant expression of these genes can be involved in the pathogenesis of cancer. The recent decade has experienced a significant attention toward the role of long non-coding RNAs (lncRNAs) in the biological functions. These transcripts regulate expression of genes at several levels, therefore influencing the activity of cancer-related pathways. Among the most affected pathways are those modulating glucose homeostasis, as well as amino acid and lipid metabolism. Moreover, critical roles of lncRNAs in regulation of mitochondrial function potentiate these transcripts as novel targets for cancer treatment. In the current review, we summarize the most recent literature regarding the role of lncRNAs in the cancer metabolism and their significance in the design of therapeutic modalities.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Long Non-coding RNAs in Cancer Metabolism: A Concise Review

2020

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“…Long noncoding RNAs (lncRNAs) are a group of non-coding RNAs with more than 200bp in length with no or limited protein-coding function, which were rst discovered in mice in 2002 and lack of speci c and complete open reading frame [3]. LncRNAs, as important regulators of transcription and translation, have been found not only involved in physiological and pathological processes, including chromatin remodeling, transcription, post-transcriptional translation, cell proliferation, differentiation and metabolic reprogramming [4][5], but also playing a pivotal role in the occurrence and development of malignant tumors [6]. Abnormal expression of lncRNAs can affect the development and progression of many kinds of malignant tumors, such as prostate cancer [7], ovarian cancer [8], breast cancer [9] and gastric cancer [10].…”

Section: Introductionmentioning

confidence: 99%

Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis

Gao

Nie

Zhang

et al. 2020

Preprint

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Background: Endometrial carcinoma (EC) is one of the most common malignant tumors in gynecology. The potential functions and mechanisms of long noncoding RNAs (lncRNAs) in the occurrence and progression of EC remains unclear. It’s meaningful to explore lncRNAs signature for providing prognostic value of EC. Methods：The differentially expressed lncRNAs and their prognostic values in EC were investigated based on The Cancer Genome Atlas (TCGA) database; the transcriptional factors (TFs), the competing endogenous RNA (ceRNA) mechanism, functional regulatory network and immune infiltration of RP11-89K21.1 and RP11-357H14.17 were further explored by various bioinformatics tools and databases. Results: We firstly identified high expression of RP11-89K21.1 and RP11-357H14.17 were closely associated with shorten overall survival (OS) and poor prognosis in patients with EC. We also elucidated the networks of transcription factor and co-expression genes associated with RP11-89K21.1 and RP11-357H14.17. Furthermore, the ceRNA network mechanism was successfully constructed through 2 lncRNAs (RP11-89K21.1 and RP11-357H14.17), 11 miRNAs and 183 mRNAs. Functional enrichment analysis revealed that the targeting genes of RP11-89K21.1 and RP11-357H14.17 were strongly associated with microRNAs in cancer, vessel development, growth regulation, growth factor and cell differentiation, and involved in pathways including pathways in cancer, microRNAs in cancer and apoptotic signaling pathway. Conclusions: We demonstrated for the first time that RP11-89K21.1 and RP11-357H14.17 may play crucial roles in the occurrence, development and malignant biological behavior of EC, and can be regarded as potential prognostic biomarkers for EC.

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“…Long noncoding RNAs (lncRNAs) are a group of noncoding RNAs with more than 200 bp in length with no or limited protein-coding function, which were first discovered in mice in 2002 and lack of specific and complete open reading frame [3]. LncRNAs, as important regulators of transcription and translation, have been found not only involved in physiological and pathological processes, including chromatin remodeling, transcription, post-transcriptional translation, cell proliferation, differentiation and metabolic reprogramming [4,5], but also playing a pivotal role in the occurrence and development of malignant tumors [6]. Abnormal expression of lncRNAs can affect the development and progression of many kinds of malignant tumors, such as prostate cancer [7], ovarian cancer [8], breast cancer [9] and gastric cancer [10].…”

mentioning

confidence: 99%

Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis

et al. 2020

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Background: Endometrial carcinoma (EC) is one of the most common malignant tumors in gynecology. The potential functions and mechanisms of long noncoding RNAs (lncRNAs) in the occurrence and progression of EC remains unclear. It's meaningful to explore lncRNAs signature for providing prognostic value of EC. Methods: The differentially expressed lncRNAs and their prognostic values in EC were investigated based on The Cancer Genome Atlas (TCGA) database; the transcriptional factors (TFs), the competing endogenous RNA (ceRNA) mechanism, functional regulatory network and immune infiltration of RP11-89K21.1 and RP11-357H14.17 were further explored by various bioinformatics tools and databases. Results: We firstly identified high expression of RP11-89K21.1 and RP11-357H14.17 were closely associated with shorten overall survival (OS) and poor prognosis in patients with EC. We also elucidated the networks of transcription factor and co-expression genes associated with RP11-89K21.1 and RP11-357H14.17. Furthermore, the ceRNA network mechanism was successfully constructed through 2 lncRNAs (RP11-89K21.1 and RP11-357H14.17), 11 miRNAs and 183 mRNAs. Functional enrichment analysis revealed that the targeting genes of RP11-89K21.1 and RP11-357H14.17 were strongly associated with microRNAs in cancer, vessel development, growth regulation, growth factor and cell differentiation, and involved in pathways including pathways in cancer, microRNAs in cancer and apoptotic signaling pathway. Conclusions: We demonstrated for the first time that RP11-89K21.1 and RP11-357H14.17 may play crucial roles in the occurrence, development and malignant biological behavior of EC, and can be regarded as potential prognostic biomarkers for EC.

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LncRNAs regulate metabolism in cancer

Cited by 130 publications

References 121 publications

The Role of Long Non-coding RNAs in Cancer Metabolism: A Concise Review

The Role of Long Non-coding RNAs in Cancer Metabolism: A Concise Review

Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis

Identification of long noncoding RNA RP11-89K21.1 and RP11-357H14.17 as prognostic signature of endometrial carcinoma via integrated bioinformatics analysis

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