LncRNAs NEAT1, HOTAIR, and GAS5 expression in hypertensive and non-hypertensive associated cerebrovascular stroke patients, and its link to clinical characteristics and severity score of the disease

Ali, Marwa A.; Shaker, Olfat; Khalifa, Abeer A.; Ezzat, Eman; Elghobary, Hany Ahmed; Mawla, Tamer Sayed Abdel; Elkhateeb, Ahmed F.; Elebiary, Ahmed Magdy Abdelrahman; Elamir, Azza

doi:10.1016/j.ncrna.2022.10.004

Cited by 14 publications

(8 citation statements)

References 39 publications

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“…Studies have shown that KLF7 expression decreases in oxidized low-density lipoprotein (ox-LDL)-induced HUVECs and inhibiting KLF7 reverses the inhibition effect of miR-301a-3p, promoting inflammation, apoptosis, and oxidative stress in ox-LDL-induced HUVECs [ 55 ]. EGR1, identified as a transcription factor activated by vascular injury, has been implicated in the pathogenesis of various vascular diseases, including AAA, TAA, atherosclerosis, myocardial ischemia/reperfusion injury, hypertension, and pathological angiogenesis [ [56] , [57] , [58] , [59] , [60] , [61] , [62] ]. This underscores the potential of EGR1 regulation as an exploitable target in IAs.…”

Section: Discussionmentioning

confidence: 99%

Integrative bioinformatics analysis of miRNA and mRNA expression profiles and identification of associated miRNA-mRNA network in intracranial aneurysms

Xu,

Gareev,

Beylerli

et al. 2024

Non-coding RNA Research

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Section: Discussionmentioning

confidence: 99%

Integrative bioinformatics analysis of miRNA and mRNA expression profiles and identification of associated miRNA-mRNA network in intracranial aneurysms

Xu,

Gareev,

Beylerli

et al. 2024

Non-coding RNA Research

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“…Interestingly, these results of involvement of HOTAIR -EZH2 axis in propagating blood brain barrier (BBB) deficits are supported by clinical data which shows that there are significant increments in HOTAIR levels of plasma samples obtained from neonatal human subjects of hypoxic‑ischemic encephalopathy (HIE) (Wang et al 2021a ). Along similar lines, Ali et al ( 2023 ) have recently evaluated the expressional changes in serum HOTAIR among cerebrovascular stroke (CVS) subjects, with and without chronic hypertension, and controls. Interestingly, they reported diminished plasma levels of HOTAIR transcripts in CVS subjects, compared to the controls.…”

Section: Hotair In Non-oncological Brain Pathophysiological ...mentioning

confidence: 97%

“…Interestingly, they reported diminished plasma levels of HOTAIR transcripts in CVS subjects, compared to the controls. Moreover, stroke subjects with chronic hypertension were found to have reduced HOTAIR levels with respect to those without hypertension (Ali et al 2023 ).…”

Section: Hotair In Non-oncological Brain Pathophysiological ...mentioning

confidence: 99%

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders

Ahmad,

Sudesh,

Ahmed

et al. 2024

Cell Mol Neurobiol

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HOX transcript antisense intergenic RNA (HOTAIR) is a long non-coding RNA (lncRNA) which is increasingly being perceived as a tremendous molecular mediator of brain pathophysiology at multiple levels. Epigenetic regulation of target gene expression carried out by HOTAIR is thorough modulation of chromatin modifiers; histone methyltransferase polycomb repressive complex 2 (PRC2) and histone demethylase lysine-specific demethylase 1 (LSD1). Incidentally, HOTAIR was the first lncRNA shown to elicit sponging of specific microRNA (miRNA or miR) species in a trans-acting manner. It has been extensively studied in various cancers, including gliomas and is regarded as a prominent pro-tumorigenic and pro-oncogenic lncRNA. Indeed, the expression of HOTAIR may serve as glioma grade predictor and prognostic biomarker. The objective of this timely review is not only to outline the multifaceted pathogenic roles of HOTAIR in the development and pathophysiology of gliomas and brain cancers, but also to delineate the research findings implicating it as a critical regulator of overall brain pathophysiology. While the major focus is on neuro-oncology, wherein HOTAIR represents a particularly potent underlying pathogenic player and a suitable therapeutic target, mechanisms underlying the regulatory actions of HOTAIR in neurodegeneration, traumatic, hypoxic and ischemic brain injuries, and neuropsychiatric disorders are also presented. Graphical Abstract HOTAIR-mediated epigenetic DNA regulation and molecular sponging of target miRNAs. While the 5′ end of HOTAIR regulates the H3K27 trimethylation activity of the catalytic subunit enhancer of Zeste homolog 2 (EZH2) of the polycomb repressive complex 2 (PRC2), its 3′ end modulates the H3K4 demethylation activity of lysine-specific demethylase 1 (LSD1). HOTAIR also binds to and competitively inhibits the functions of target miRNAs, altering the expression of downstream genes.

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“…As a special type of lncRNA, the roles of HOX-lncRNAs in essential hypertension have rarely been studied. However, studies have shown that HOTAIR expression is significantly downregulated in stroke patients with hypertension compared to that in stroke patients without hypertension ( 79 ), suggesting that it may be closely related to the occurrence and development of hypertension and that it could be used as a biomarker for the diagnosis and treatment of this condition.…”

Section: Hox-lncrnas and Other Aspects Of Cardiovascular Biologymentioning

confidence: 99%

Spotlight on HOX cluster‑embedded antisense lncRNAs in cardiovascular diseases (Review)

Zhou,

2023

Int J Mol Med

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Atherosclerosis is a complex and chronic inflammatory disease driven by multiple pathophysiological processes that are responsible for diverse cardiovascular events. Atherosclerotic cardiovascular disease, despite substantial triumphs in primary and secondary prevention, remains a dominant epidemic that impairs human health. Therefore, deciphering the pathogenesis of atherosclerosis will provide a real-world translational understanding. Homeobox cluster-embedded antisense long non-coding RNAs (HOX-lncRNAs), a nascent class of lncRNA molecules with versatile roles in cancer, can also orchestrate various cell functions in cardiovascular disorders and have thus captured the attention of many researchers. Subsequently, numerous studies have demonstrated the role of HOX-lncRNAs as potential modulators of atherosclerosis. Nevertheless, given that the understanding of HOX-lncRNAs in atherosclerosis is only just emerging, ongoing research must be initiated to thoroughly pinpoint such causal roles. The present review aimed to highlight the important contributions of HOX-lncRNAs to atherosclerosis and other pivotal biological processes related to cardiovascular disease. The review concludes with a discussion of the limitations, outlook, challenges and possible solutions associated with HOX-lncRNAs in atherosclerosis. Looking forward, this may lead to extraordinary breakthroughs in revealing the molecular underpinnings of HOX-lncRNAs and may offer a promising yet challenging landscape for robust therapeutic strategies for atherosclerosis and/or associated cardiovascular disorders.

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LncRNAs NEAT1, HOTAIR, and GAS5 expression in hypertensive and non-hypertensive associated cerebrovascular stroke patients, and its link to clinical characteristics and severity score of the disease

Cited by 14 publications

References 39 publications

Integrative bioinformatics analysis of miRNA and mRNA expression profiles and identification of associated miRNA-mRNA network in intracranial aneurysms

Integrative bioinformatics analysis of miRNA and mRNA expression profiles and identification of associated miRNA-mRNA network in intracranial aneurysms

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS Disorders

Spotlight on HOX cluster‑embedded antisense lncRNAs in cardiovascular diseases (Review)

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