LncRNAs have a say in protein translation

Huarte, Maite

doi:10.1038/cr.2012.169

Cited by 27 publications

(15 citation statements)

References 12 publications

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“…Further sequencing and annotation of these transcripts leads to the discovery of thousands of long noncoding RNAs (lncRNAs), which is longer than 200 nt in length and lacking of protein coding capacity . In addition, emerging studies indicate that lncRNAs are key regulators involved in almost every aspect of intracellular biological process, including the chromatin remodeling, X chromatin imprinting, cell differentiation and fate decision, immune response, tumor cells growth and metastasis etc . Importantly, lncRNAs dysregulation have been reported in diverse human disease, especially cancers .…”

Section: Introductionmentioning

confidence: 99%

An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer

et al. 2019

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Ovarian cancer is one of the most common female reproductive system malignancies worldwide. Recently, the aberrant long noncoding RNAs (lncRNAs) expression has been identified in multiple cancers. Emerging evidence has highlighted the critical roles of lncRNAs in carcinogenesis and tumor progression, including ovarian cancer. The objective of this study is to comprehensively analyze lncRNAs expression pattern, and explore their clinical significance and underlying mechanism in human ovarian cancer. In this study, we found hundreds of dysregulated lncRNAs in ovarian cancer by performing genome‐wide analysis using RNA sequencing data from Genotype‐Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) project, and three microarray datasets from Gene Expression Omnibus (GEO). Moreover, our results revealed that up‐ or down‐regulation of some lncRNAs expression in ovarian cancer is accompanied by their genomic loci copy number amplification or deletion. Importantly, some lncRNAs expression levels are significantly associated with ovarian cancer patients’ poor prognosis. Further experimental validation and mechanistic investigation indicate that LINC00511 exerts oncogenic function in ovarian cancer cells through interacting with EZH2 and repressing P21 expression. Taken together, the findings in the current study may provide a useful resource of novel ovarian cancer associated lncRNAs and potential diagnostic biomarker and therapeutic targets for ovarian cancer.

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Section: Introductionmentioning

confidence: 99%

An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer

et al. 2019

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“…A close connection between downregulation of UCHL1 and mechanisms of the pathology of AD is well documented. Some LncRNAs have been detected to have a say in regulating in UCHL1 levels, thus documenting possible mechanisms of decreased UCHL1 levels in AD patients [16][17][18]. Grape seed procyanidin b2 is observed to increase UCHL1 levels in the research of cardiovascular diseases [19].…”

Section: Discussionmentioning

confidence: 95%

Downregulation of Ubiquitin Carboxyl-terminal Hydrolase L1 (UCHL1) Expression in the Pathogenesis of Alzheimers Disease

Shen¹,

Zhao²,

You³

et al. 2018

Brain Disord Ther

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The pathogenesis of Alzheimer's disease (AD) has not been definitely confirmed so far. As a result, a cure for AD is lacking, and current treatments are limited to modest symptomatic relief. Accumulation of damaged proteins and formation of protein aggregates are found in AD brains, suggesting impairment of protein degradation is contained by the pathogenesis of AD. Impairment of ubiquitin-proteasome system has been found in Alzheimer Disease. Here we demonstrate ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) which plays a role in neuronal ubiquitination/deubiquitination machinery participates in the pathogenesis of AD.

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“…Recently, lncRNAs were reported to be involved in numerous biological process and be connected with various diseases, such as cancer (27)(28)(29), and many lncRNAs play critical roles in regulating gene expression (30,31). Since AFAP1-AS1 (an lncRNA transcript) was demonstrated differentially expressed in esophageal adenocarcinoma, an increasing number of aberrant expression of lncRNAs have been reported in esophageal cancer (32).…”

Section: Discussionmentioning

confidence: 99%

Microarray expression profile analysis of aberrant long non-coding RNAs in esophageal squamous cell carcinoma

Yao

Huang

Lin

et al. 2016

International Journal of Oncology

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Increasing evidence indicates that long non-coding RNA (lncRNA) plays an important role in tumorigenesis. However, the function and regulatory mechanism of lncRNAs are still unclear in esophageal squamous cell carcinoma (ESCC). To address this challenge, we screened lncRNAs expression profiles in 3 pairs of ESCC and matched non-cancerous tissues by microarray assay and identified the relationship between lncRNAs expression in ESCC tissue and clinicopathological characteristics and prognosis of patients with ESCC. We found 182 lncRNAs that were significantly differently expressed in ESCC tissues versus the matched non-cancerous tissues. Gene ontology and pathway analysis results suggested that the primary biological processes of these genes were involved in extracellular matrix, immune responses, cell differentiation and cell proliferation. Through cis and trans analyzing, we found 4 lncRNAs (ENST00000480669, NONHSAT104436, NONHSAT126998 and NONHSAT112918) may play important roles in tumorigenesis of ESCC. The four lncRNAs were checked in 73 patients with ESCC. The results showed that they mainly related to tumor metastasis. Kaplan-Meier survival analysis showed that high expression of NONHSAT104436, NONHSAT126998 and low expression of ENST00000480669 were related to poor 3-year overall survival (P=0.003, 0.032 and 0.040, respectively). Multivariate analysis showed that NONHSAT104436 was an independent prognostic factor (P=0.017). Thus we concluded that, lncRNAs showed differently expression patterns in ESCC versus matched non-cancerous tissues, and aberrantly expressed lncRNA may play important roles in ESCC development and progression. Interestingly, the overexpression of NONHSAT104436 was tightly correlated with distant metastasis and, poor survival rate, which might indicate that NONHSAT104436 might play a very important part in ESCC tumor progression.

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LncRNAs have a say in protein translation

Cited by 27 publications

References 12 publications

An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer

An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer

Downregulation of Ubiquitin Carboxyl-terminal Hydrolase L1 (UCHL1) Expression in the Pathogenesis of Alzheimers Disease

Microarray expression profile analysis of aberrant long non-coding RNAs in esophageal squamous cell carcinoma

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