LncRNAs: Emerging Biomarkers in Gastric Cancer

Gu, Yu; Chen, Tianxiang; Li, Guangliang; Yu, Xiaofei; Lu, Yimin; Wang, Haohao; Teng, Lisong

doi:10.2217/fon.15.175

Cited by 93 publications

(64 citation statements)

References 108 publications

(171 reference statements)

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“…Given their cell-specific expression, lncRNAs have been described as potential biomarkers in various cancers types such as gastric [72], lung [73], prostate [74], and hepatocellular carcinoma [75]. Similarly, several lncRNAs have been identified as potential biomarkers in cells with different OC histotypes, where their expressions levels are altered.…”

Section: Lncrna Signature As a Diagnostic And Prognostic Biomarker Of Ocmentioning

confidence: 99%

Long Non-Coding RNAs: the New Horizon of Gene Regulation in Ovarian Cancer

Worku

Bhattarai

Ayers

et al. 2017

Cell Physiol Biochem

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Long non-coding RNAs (lncRNAs), a class of non-coding transcripts, have recently been emerging with heterogeneous molecular actions, adding a new layer of complexity to generegulation networks in tumorigenesis. LncRNAs are considered important factors in several ovarian cancer histotypes, although few have been identified and characterized. Owing to their complexity and the lack of adapted molecular technology, the roles of most lncRNAs remain mysterious. Some lncRNAs have been reported to play functional roles in ovarian cancer and can be used as classifiers for personalized medicine. The intrinsic features of lncRNAs govern their various molecular mechanisms and provide a wide range of platforms to design different therapeutic strategies for treating cancer at a particular stage. Although we are only beginning to understand the functions of lncRNAs and their interactions with microRNAs (miRNAs) and proteins, the expanding literature indicates that lncRNA-miRNA interactions could be useful biomarkers and therapeutic targets for ovarian cancer. In this review, we discuss the genetic variants of lncRNAs, heterogeneous mechanisms of actions of lncRNAs in ovarian cancer tumorigenesis, and drug resistance. We also highlight the recent developments in using lncRNAs as potential prognostic and diagnostic biomarkers. Lastly, we discuss potential approaches for linking lncRNAs to future gene therapies, and highlight future directions in the field of ovarian cancer research.

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Section: Lncrna Signature As a Diagnostic And Prognostic Biomarker Of Ocmentioning

confidence: 99%

Long Non-Coding RNAs: the New Horizon of Gene Regulation in Ovarian Cancer

Worku

Bhattarai

Ayers

et al. 2017

Cell Physiol Biochem

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“…Increasing studies have revealed that lncRNAs have important influence in tumorigenesis, metastasis, and prognosis and drug resistance of gastric cancer [1]. While the functional role and molecular mechanism of many GCassociated lncRNAs remain undetermined, recent studies revealed that several lncRNAs are associated with GC progression, such as H19, FENDRR, and MRUL [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

“…GC is one of the prominent cancers with high morbidity and mortality in developing countries and half of the world total occurs in eastern Asia (mainly in China). The rate of GC has dropped greatly over the last half-century in most developed western countries, but has not decreased in East Asia [1,2]. Deeper understanding of the molecular mechanism of GC will provide novel insights into its pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer

Zhou

Shi

et al. 2018

Oncotarget

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“…Therefore, further studies on GC tissues from endoscopic biopsy may aid in establishing the associations between lncRNAs and GC. Previous studies have identified a subset of lncRNAs that are associated with GC, indicating their wide participation in the development and progression of GC (13,14). However, the biological functions and mechanisms of these lncRNAs remain unexplored (11).…”

Section: Introductionmentioning

confidence: 99%

Identification and functional characterization of long non-coding RNAs in human gastric cancer

Liang

Yao

et al. 2018

Oncol Lett

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Abstract. Abnormal regulation of long non-coding RNAs (lncRNAs) appears to be a primary feature of numerous types of human cancer. However, the association between the dysregulation of lncRNAs and functional alterations in gastric cancer (GC) remains unclear. In previous studies, we applied microarray and bioinformatics analyses to screen for key lncRNAs from the tumor tissues and matched adjacent non-tumor tissues of 10 patients with GC. There were seven key lncRNAs demonstrated to be significantly different between carcinoma tissues and adjacent non-tumor tissues. In the present study, the expression of these seven selected lncRNAs were validated in 82 patients with GC to further investigate the association between lncRNAs and GC clinical characterization. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) results demonstrated that RP5-919F19, MCPH1 antisense RNA 1 (CTD-2541M15) and urothelial carcinoma-associated 1 (UCA1) exhibited consistent upregulation in cancer compared with adjacent non-tumor tissues, whereas AP000459, LOC101928316, tumor suppressor candidate 8 (LINC01071) and maternally expressed 3 (MEG3) showed consistent downregulation. The results from the microarray and RT-qPCR experiments achieved 100% agreement. A correlation analysis indicated that RP5-919F19, LOC101928316 and MEG3 were significantly associated with tumor differentiation degree, RP5-919F19, UCA1 and MEG3 were significantly associated with lymph node metastasis, and RP5-919F19, CTD-2541M15 and UCA1 were significantly associated with tumor-node-metastasis stage (P<0.05). In addition, it was identified that the differential expression of LINC01071 and LOC101928316 significantly correlated with the age and gender of the GC patients, respectively (P<0.05). The results suggest that the lncRNAs RP5-919F19, LOC101928316, CTD-2541M15, UCA1 and MEG3 are closely associated with the invasion and metastasis of GC, which reveals these indicators as potential specificity biomarkers for the diagnosis, prognosis and classification of GC. Thus, these lncRNAs merit further study as novel candidate biomarkers for the clinical diagnosis of GC and as potential targets for therapy. IntroductionGastric cancer (GC) is one of the most lethal types of cancer and has been increasing in incidence and mortality over the last several decades. In China, it has been estimated that ~464,000 new cases were diagnosed in 2012, which accounts for over 40% of the total cases (~989,600) worldwide (1). According to evidence from clinical studies, the majority of patients with GC are diagnosed at an advanced stage and are thus not suitable for radical surgery (2). Previous studies have also reported that earlier diagnosis and treatment of GC could produce a 5-year survival rate of >90% (3).Recent developments in the field of digestive system endoscopy have been remarkable due to their association with decreased trauma, accelerated recovery and fewer complications (4,5). However, endoscopic biopsy and observation of pathological morphology are unable t...

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LncRNAs: Emerging Biomarkers in Gastric Cancer

Cited by 93 publications

References 108 publications

Long Non-Coding RNAs: the New Horizon of Gene Regulation in Ovarian Cancer

Long Non-Coding RNAs: the New Horizon of Gene Regulation in Ovarian Cancer

Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer

Identification and functional characterization of long non-coding RNAs in human gastric cancer

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