LncRNA XR_351665 Contributes to Chronic Pain-Induced Depression by Upregulating DNMT1 via Sponging miR-152-3p

Ding, Xiaobao; Lin, Yu‐Wen; Yan, Binbin; Jiao, Xiaowei; Liu, Qiang; Miao, Huihui; Wu, Yuqing; Zhou, Chenghua

doi:10.1016/j.jpain.2022.10.006

Cited by 4 publications

(3 citation statements)

References 64 publications

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“…At the onset of depression, lncRNA XR_351665 increases DNA methyltransferase1 (DNMT1) by sponging miR-152-3p, which leads to chronic depression In postpartum depression, lncRNA Gm14205 activates the NLRP3 inflammasome by blocking the oxytocin receptor [ 93 , 94 ]. MiRNA-320-3p/CRHR1 (G protein-coupled receptors) axis-mediated induction of neuronal vitality in rats’ brains to aggravate depression is regulated by lncRNA NEAT1 [ 95 ].…”

Section: Lncrnamentioning

confidence: 99%

“…As a sponge, MIR 155 HG has been shown to lessen the inhibitory impact of miR-155 on BDNF production and enhance depressive-like behaviour [ 96 ]. The lncRNA XR_351665 upregulates1 by acting as a miR-152-3p sponge, thereby contributing to the development of depression induced by chronic pain [ 93 ]. Consequently, it is highly plausible that lncRNAs exert an impact on depression through their interaction with miRNAs.…”

Section: Interconnections Between Ncrnas In Depressionmentioning

confidence: 99%

See 1 more Smart Citation

The role of ncRNAs in depression

Luan,

Xing,

Guo

et al. 2024

Heliyon

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Section: Lncrnamentioning

confidence: 99%

Section: Interconnections Between Ncrnas In Depressionmentioning

confidence: 99%

The role of ncRNAs in depression

Luan,

Xing,

Guo

et al. 2024

Heliyon

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“… 469 , 470 Subsequently, DNMT1 expression in GABAergic neurons is upregulated, partially due to the positive functions of upstream lncRNA XR_351665. 471 The DNMT1-mediated DNA methylation network suppresses GABAergic neuron activity, inducing comorbid depressive symptoms. 472 Additionally, some studies reveal the side effects of active protection from neuropathic pain.…”

Section: Mechanisms Of Pain Comorbiditiesmentioning

confidence: 99%

Pathology of pain and its implications for therapeutic interventions

Cao,

Xu,

Shi

et al. 2024

Sig Transduct Target Ther

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Pain is estimated to affect more than 20% of the global population, imposing incalculable health and economic burdens. Effective pain management is crucial for individuals suffering from pain. However, the current methods for pain assessment and treatment fall short of clinical needs. Benefiting from advances in neuroscience and biotechnology, the neuronal circuits and molecular mechanisms critically involved in pain modulation have been elucidated. These research achievements have incited progress in identifying new diagnostic and therapeutic targets. In this review, we first introduce fundamental knowledge about pain, setting the stage for the subsequent contents. The review next delves into the molecular mechanisms underlying pain disorders, including gene mutation, epigenetic modification, posttranslational modification, inflammasome, signaling pathways and microbiota. To better present a comprehensive view of pain research, two prominent issues, sexual dimorphism and pain comorbidities, are discussed in detail based on current findings. The status quo of pain evaluation and manipulation is summarized. A series of improved and innovative pain management strategies, such as gene therapy, monoclonal antibody, brain-computer interface and microbial intervention, are making strides towards clinical application. We highlight existing limitations and future directions for enhancing the quality of preclinical and clinical research. Efforts to decipher the complexities of pain pathology will be instrumental in translating scientific discoveries into clinical practice, thereby improving pain management from bench to bedside.

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