LncRNA XLOC_003810 promotes T cell activation and inhibits PD‐1/PD‐L1 expression in patients with myasthenia gravis‐related thymoma

Hu, Bo; Niu, Li; Jiang, Zheng; Xu, Shenglin; Hu, Yong; Cao, Kejiang

doi:10.1111/sji.12886

Cited by 18 publications

(14 citation statements)

References 26 publications

(52 reference statements)

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“…MG is a complex disease and the pathogenetic mechanisms and autoimmune processes involved are still unclear. An extensive body of evidence now supports the fact that lncRNAs play a regulatory role in the immune system and can exert influence in numerous autoimmune diseases and MG 7 , 36 . The identification of SNPs in lncRNA-mediated ceRNA regulation pairs in MG by considering relevant risk pathways could help us to illustrate the potential roles of lncRNA-SNPs in the progression of MG.…”

Section: Discussionmentioning

confidence: 97%

Competitive endogenous RNA network and pathway-based analysis of LncRNA single-nucleotide polymorphism in myasthenia gravis

Wang

Zhang

et al. 2021

Sci Rep

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Myasthenia gravis (MG) is a complex neurological autoimmune disease with a pathogenetic mechanism that has yet to be elucidated. Emerging evidence has revealed that genes, non-coding RNAs and genetic variants play significant roles in the pathogenesis of MG. However, the molecular mechanisms of single nucleotide polymorphisms (SNPs) located on lncRNAs could disturb lncRNA-mediated ceRNA regulatory functions still unclear in MG. In this study, we collated 276 experimentally confirmed MG risk genes and 192 MG risk miRNAs. We then constructed a lncRNA-mediated ceRNA network for MG based on multi-step computational strategies. Next, we systematically integrated risk pathways and identified candidate SNPs in lncRNAs for MG based on data acquired from public databases. In addition, we constructed a pathway-based lncRNA-SNP mediated network (LSPN) that contained 128 lncRNAs targeting 8 MG risk pathways. By analyzing network, we propose a latent mechanism for how the “lncRNA-SNP-mRNA-pathway” axis affects the pathogenesis of MG. Moreover, 25 lncRNAs and 51 SNPs on lncRNAs were extracted from the “lncRNA-SNP-mRNA-pathway” axis. Finally, functional analyses demonstrated lncRNA-SNPs mediated ceRNA regulation pairs associated with MG participated in the MAPK signaling pathway. In summary, we constructed MG-specific lncRNA-SNPs mediated ceRNA regulatory networks based on pathway in the present study, which was helpful to elucidate the roles of lncRNA-SNPs in the pathogenesis of MG and provide novel insights into mechanism of lncRNA-SNPs as potential genetic risk biomarkers of MG.

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Section: Discussionmentioning

confidence: 97%

Competitive endogenous RNA network and pathway-based analysis of LncRNA single-nucleotide polymorphism in myasthenia gravis

Wang

Zhang

et al. 2021

Sci Rep

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“…Multiple lncRNAs have been shown to be involved in the process. For instance, Bo Hu et al revealed that lncRNA XLOC_003810 decreased the proportion of CD4 + PD-1 + T cells in patients with MG [33].…”

Section: Activationmentioning

confidence: 99%

Potential impact and mechanism of Long Non-coding RNAs on cancer and associated T cells

Chen¹,

Liu²,

Wang³

2021

J. Cancer

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The discovery of many aberrant expressions of long non-coding RNAs (lncRNAs) in various cancers has focused attention on the effects of lncRNA on cancer cells themselves, including cell proliferation, growth inhibition, cell migration, cell immortality, vascular regeneration and cell viability. But with the increasing role of immunotherapy in cancer therapy, a large number of studies have revealed that the regulatory role of lncRNAs in immunity such as differentiation of immune cells can also influence the development and progression of cancer. In particular, recent publications have suggested that lncRNAs play critical roles in T-lymphocyte activation, proliferation, differentiation, function, apoptosis and metabolism. To elucidate the actual functions of lncRNAs at the molecular level of cancer pathogenesis, we summarize some of the current lncRNA regulatory mechanisms associated with T cell to discuss their effects in cancer in the hope of providing potential cancer therapeutic targets or cancer biomarkers. However, we all know that the differentiation and function of T cells is an extremely complex process that involves the expression and regulation of multiple lncRNAs. As a result, more regulatory mechanisms of lncRNAs need to be further studied.

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“…XLOC_003810 silencing has resulted in opposite effects. Cumulatively, XLOC_003810 is an lncRNA that enhances T cells activation and suppresses PD-1/PD-L1 signaling in MG-T patients [ 10 ]. Another study has shown higher levels of XLOC_003810 in thymic CD4+ T cells obtained from MG-T patients compared with the control group.…”

Section: Lncrnas and Mgmentioning

confidence: 99%

A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis

Ghafouri‐Fard

Azimi

Hussen

et al. 2021

IJMS

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Myasthenia gravis (MG) is an autoimmune condition related to autoantibodies against certain proteins in the postsynaptic membranes in the neuromuscular junction. This disorder has a multifactorial inheritance. The connection between environmental and genetic factors can be established by epigenetic factors, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). XLOC_003810, SNHG16, IFNG-AS1, and MALAT-1 are among the lncRNAs with a possible role in the pathoetiology of MG. Moreover, miR-150-5p, miR-155, miR-146a-5p, miR-20b, miR-21-5p, miR-126, let-7a-5p, and let-7f-5p are among miRNAs whose roles in the pathogenesis of MG has been assessed. In the current review, we summarize the impact of miRNAs and lncRNAs in the development or progression of MG.

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LncRNA XLOC_003810 promotes T cell activation and inhibits PD‐1/PD‐L1 expression in patients with myasthenia gravis‐related thymoma

Cited by 18 publications

References 26 publications

Competitive endogenous RNA network and pathway-based analysis of LncRNA single-nucleotide polymorphism in myasthenia gravis

Competitive endogenous RNA network and pathway-based analysis of LncRNA single-nucleotide polymorphism in myasthenia gravis

Potential impact and mechanism of Long Non-coding RNAs on cancer and associated T cells

A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis

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