LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson’s disease progression

Zhou, Qian; Zhang, Mingming; Liu, Min; Tan, Zhigang; Qin, Qiang; Jiang, Yugang

doi:10.18632/aging.202378

Cited by 37 publications

(25 citation statements)

References 43 publications

(27 reference statements)

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“…Long non-coding RNAs (lncRNAs) are part of non-coding RNAs with sizes between 200 nucleotides and several kbs and high tissue specificity. They have fundamental role in regulation of gene expression (Zhou et al, 2021 ). According to the Annotations of the FANTOM5 project, about 28,000 lncRNA genes have been identified so far (Hon et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

Asadi

Hassani

Kiani

et al. 2021

Front. Aging Neurosci.

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LncRNAs act as part of non-coding RNAs at high levels of complex and stimulatory configurations in basic molecular mechanisms. Their extensive regulatory activity in the CNS continues on a small scale, from the functions of synapses to large-scale neurodevelopment and cognitive functions, aging, and can be seen in both health and disease situations. One of the vast consequences of the pathological role of dysregulated lncRNAs in the CNS due to their role in a network of regulatory pathways can be manifested in Alzheimer's as a neurodegenerative disease. The disease is characterized by two main hallmarks: amyloid plaques due to the accumulation of β-amyloid components and neurofibrillary tangles (NFT) resulting from the accumulation of phosphorylated tau. Numerous studies in humans, animal models, and various cell lines have revealed the role of lncRNAs in the pathogenesis of Alzheimer's disease. This scoping review was performed with a six-step strategy and based on the Prisma guideline by systematically searching the publications of seven databases. Out of 1,591 records, 69 articles were utterly aligned with the specified inclusion criteria and were summarized in the relevant table. Most of the studies were devoted to BACE1-AS, NEAT1, MALAT1, and SNHG1 lncRNAs, respectively, and about one-third of the studies investigated a unique lncRNA. About 56% of the studies reported up-regulation, and 7% reported down-regulation of lncRNAs expressions. Overall, this study was conducted to investigate the association between lncRNAs and Alzheimer's disease to make a reputable source for further studies and find more molecular therapeutic goals for this disease.

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Section: Introductionmentioning

confidence: 99%

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

Asadi

Hassani

Kiani

et al. 2021

Front. Aging Neurosci.

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“…In Ewing’s sarcoma, the target regulatory interaction between miR-199a-3p and TUG1 is confirmed [ 27 ]. Increasing evidence has revealed the important role of miR-199a-3p in neurological diseases [ 28–30 ]. MiR-199a-3p is reported to play a protective role in neuron cells in a variety of diseases [ 14 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, low levels of miR-199a-3p were detected in TLE patients, which was negatively correlated with the levels of TUG1. In a study about Parkinson’s disease, miR-199a-3p overexpression can protect against the disease progression via inhibiting neuron cell apoptosis and promoting cell proliferation [ 28 ]. In light of the target relationship of miR-199a-3p with TUG1, we speculated that miR-199a-3p might be involved in the regulatory role of TUG1 in TLE.…”

Section: Discussionmentioning

confidence: 99%

Clinical value of lncRNA TUG1 in temporal lobe epilepsy and its role in the proliferation of hippocampus neuron via sponging miR-199a-3p

Zheng

et al. 2021

Bioengineered

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Temporal lobe epilepsy (TLE) often occurs in childhood and is the most common type of epilepsy. Studies have confirmed that long non-coding RNAs (lncRNAs) can affect the progression of neurological diseases. This study explored the expression level of lncRNA TUG1 in TLE children and its clinical significance and investigated its role in hippocampal neurons. 86 healthy individuals and 88 TLE children were recruited. The expressions of lncRNA TUG1 and miR-199a-3p in serum were detected by qRT-PCR. Hippocampal neurons were treated with non-Mg 2+ to establish TLE cell model. MTT assay and flow cytometry assay was used to detect the effect of lncRNA TUG1 on the proliferation and apoptosis of hippocampal neurons. A dual-luciferase reporter assay was done to confirm the target relationship. The expression of lncRNA TUG1 was increased in TLE children compared with the control group. The diagnostic potential was reflected by the receiver operator characteristic (ROC) curve, with the AUC of 0.915 at the cutoff value of 1.256. Elevated levels of TUG1 were detected in TLE cell models, and TUG1 knockout could enhance cell activity and inhibit cell apoptosis. MiR-199a-3p was the target of TUG1. Clinically, the serum miR-199a-3p levels showed a negative association with TUG1. LncRNA TUG1 may be a biomarker of TLE diagnosis in children, and can regulate hippocampal neuron cell activity and apoptosis via sponging miR-199a-3p.

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“…LRRK2 gene has been acknowledged to be associated with PD. Researchers found that Hox transcript antisense intergenic RNA (HOTAIR), X-inactive specific transcript (XIST), and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) indirectly enhanced the expression of LRRK2, which would increase the rate of apoptosis (Wang et al, 2017 ; Chen Q. et al, 2018 ; Zhou Q. et al, 2021 ). HOTAIR may also promote apoptosis of neuronal cells through microRNA-126-5p (miR-126-5p)/RAB3A-interacting protein (RAB3IP) axis (Lin et al, 2019 ).…”

Section: How Do the Ncrnas Regulate Parkinson’s Disease?mentioning

confidence: 99%

Crosstalk between regulatory non-coding RNAs and oxidative stress in Parkinson’s disease

Zhang

Liu

et al. 2022

Front. Aging Neurosci.

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Parkinson’s disease is the second most common neurodegenerative disease after Alzheimer’s disease, which imposes an ever-increasing burden on society. Many studies have indicated that oxidative stress may play an important role in Parkinson’s disease through multiple processes related to dysfunction or loss of neurons. Besides, several subtypes of non-coding RNAs are found to be involved in this neurodegenerative disorder. However, the interplay between oxidative stress and regulatory non-coding RNAs in Parkinson’s disease remains to be clarified. In this article, we comprehensively survey and overview the role of regulatory ncRNAs in combination with oxidative stress in Parkinson’s disease. The interaction between them is also summarized. We aim to provide readers with a relatively novel insight into the pathogenesis of Parkinson’s disease, which would contribute to the development of pre-clinical diagnosis and treatment.

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LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson’s disease progression

Cited by 37 publications

References 43 publications

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

The Perspective of Dysregulated LncRNAs in Alzheimer's Disease: A Systematic Scoping Review

Clinical value of lncRNA TUG1 in temporal lobe epilepsy and its role in the proliferation of hippocampus neuron via sponging miR-199a-3p

Crosstalk between regulatory non-coding RNAs and oxidative stress in Parkinson’s disease

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